Art

J-GLOBAL ID：202102246827294179   Reference number：21A0141314

Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis

星状細胞は孤発性筋萎縮性側索硬化症に関連する酸化ストレス増加に応答して上方制御されるシスチン/グルタミン酸アンチポーターを介してグルタミン酸を放出する

Author (11)： Kazama Miku (Faculty of Medicine, Tokyo Women’s Medical University, Tokyo, Japan) ,  Kato Yoichiro (Division of Pathological Neuroscience, Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Kakita Akiyoshi (Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan) ,  Noguchi Noriko (Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan) ,  Urano Yasuomi (Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan) ,  Masui Kenta (Division of Pathological Neuroscience, Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Niida-Kawaguchi Motoko (Division of Pathological Neuroscience, Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Yamamoto Tomoko (Division of Pathological Neuroscience, Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Watabe Kazuhiko (Department of Medical Technology, Kyorin University, Tokyo, Japan) ,  Kitagawa Kazuo (Department of Neurology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Shibata Noriyuki (Faculty of Medicine, Tokyo Women’s Medical University, Tokyo, Japan)
Material： Neuropathology (Web)  (日本神経病理学会総会学術研究会プログラム・抄録集(Web))
Volume： 40  Issue： 6  Page： 587-598  Publication year： 2020 
JST Material Number： U0508A  ISSN： 1440-1789  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： sulfur containing amino acid ,...
Semi thesaurus term： *Sporadic amyotrophic lateral sclerosis ,...

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Author keywords (5)： amyotrophic lateral sclerosis ,  astrocyte ,  glutamate ,  oxidative stress ,  xCT

JST classification (1)： Basic neurology  (GN01020W)

Substance index (2)： Cystine ,  Glutamic acid

Terms in the title (9)： 星状細胞 ,  孤発性筋萎縮性側索硬化症 ,  酸化ストレス ,  応答 ,  上方制御 ,  シスチン ,  グルタミン酸 ,  アンチポーター ,  放出