Art
J-GLOBAL ID：202102264764872466   Reference number：21A0425290

ARE-Nrf2 luciferase LuSens test method for skin sensitization (LuSens test method)

皮膚感作性試験代替法:ARE-Nrf2 Inciferase LuSens Test Method(LuSens法)
Author (7)：
KOJIMA KOICHI

About KOJIMA KOICHI

(食品薬品安全セ)

About 食品薬品安全セ

, 
ASHIKAGA TAKAO

About ASHIKAGA TAKAO

(医薬品食品衛生研)

About 医薬品食品衛生研

, 
ADACHI REIKO

About ADACHI REIKO

(福井大)

About 福井大

, 
SATO KAZUHIRO

About SATO KAZUHIRO

(福井大)

About 福井大

, 
SEZAKI TAKUHITO

About SEZAKI TAKUHITO

(三井化学)

About 三井化学

, 
TAKEYOSHI MASAHIRO

About TAKEYOSHI MASAHIRO

(化学物質評価研究機構)

About 化学物質評価研究機構

, 
FUKUYAMA TOMOKI

About FUKUYAMA TOMOKI

(麻布大)

About 麻布大


Material：
AATEX-JaCVAM  (AATEX JaCVAM)

About AATEX-JaCVAM


Volume： 9  Issue： 1  Page： 43-57  Publication year： Nov. 30, 2020 
JST Material Number： F1276A  ISSN： 2187-3690  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*sensitization(immunology)

About sensitization(immunology)

,...
Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
gene for luciferase

About gene for luciferase

,...
Register(free) or Log In to access 

Please login to MyJ-GLOBAL to see full information. You also need to select "Display abstract, etc. of medical articles" in your MyJ-GLOBAL account page in order to see abstracts, etc. of medical articles.

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A0425290&from=J-GLOBAL&jstjournalNo=F1276A") }}
JST classification (2)：
JST classification
Category name(code) classified by JST.
Toxicity of chemical substances in general 
(GZ02010C)

About Toxicity of chemical substances in general

,  Dermatology in general 
(GF01010N)

About Dermatology in general

Reference (13)：
  • OECD (2018). Key event based test guideline. In vitro skin sensitization assay addressing the AOP key event on keratinocyte activation. OECD Guideline for the Testing of Chemicals. No. 442D, OECD, Paris. Accessible at: https://www.oecd-ilibrary.org/docserver/9789264229822-en.pdf?expires=1540286232&id=id&accname=guest&checksum=F9DC614E0BBF02D46223C8FCABCFBA5E
  • EURL ECVAM (2018). The LuSens Test Method Validation Study Report. Accessible at; https://tsar.jrc.ec.europa.eu/test-method/tm2011-10
  • ESAC (2016). ESAC Opinion on the BASF-coordinated Performance Standards-based validation of the LuSens test method for skin sensitization testing. Available at: http://publications.jrc.ec.europa.eu/repository/bitstream/JRC103706/esac_opinion_2016-04_lusens_final.pdf
  • Ade N, Leon F, Pallardy M, Peiffer JL, Kerdine-Romer S, Tissier MH, Bonnet PA, Fabre I, Ourlin JC; HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in den-dritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway. Toxicol Sci. 2009; 107(2): 451-60.
  • Vandebriel RJ, Pennings JL, Baken KA, Pronk TE, Boorsma A, Gottschalk R, Van Loveren H; Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010; 117(1):81-9.
ｍore...
Terms in the title (5)：
Terms in the title
Keywords automatically extracted from the title.
皮膚

About 皮膚

, 
感作性試験

About 感作性試験

, 
代替法

About 代替法

, 
ARE

About ARE

, 
NRF2

About NRF2


Return to Previous Page

TOP

BOTTOM