Art

J-GLOBAL ID：202102285734110358   Reference number：21A0159478

Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson’s disease

パーキンソン病のロテノン誘発ラットモデルの脳におけるDHA補給の有益な効果に対するチトクロームP450と可溶性エポキシドヒドロラーゼによって産生されるDHAジオール(19,20-DHDP)の寄与【JST・京大機械翻訳】

Author (7)： Oguro Ami (Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan) ,  Ishihara Yasuhiro (Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan) ,  Siswanto Ferbian Milas (Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda 669-1337, Japan) ,  Yamazaki Takeshi (Program of Life and Environmental Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan) ,  Ishida Atsuhiko (Program of Life and Environmental Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan) ,  Imaishi Hiromasa (Division of Signal Responses, Biosignal Research Center, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan) ,  Imaoka Susumu (Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda 669-1337, Japan)
Material： Biochimica et Biophysica Acta  (BBA. Biomembranes)
Volume： 1866  Issue： 2  Page： Null  Publication year： 2021 
JST Material Number： B0207A  ISSN： 0005-2728  CODEN： BBBMBS  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Docosahexaenoic acid (DHA) has...

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Thesaurus term： mRNA ,  gene ,  catalase ,  Corpus Striatum ,  metabolite ,  tyrosine hydroxylase ,  *Rattus ,  hydroxylation ,  LC-MS analysis ,  *Parkinson's disease ,  *diol ,  protein expression ,  NF-E2-Related Factor 2 ,  mRNA expression ,  peroxidase ,  *Myomorpha ,  ketone ,  oxygen heterocyclic compound ,  olefin compound ,  phenol ether ,  polynuclear aromatic compound

Author keywords (7)： Docosahexaenoic acid (DHA) ,  Cytochrome P450 (P450) ,  Soluble epoxide hydrolase (sEH) ,  Epoxydocosapentaenoic acids (EDPs) ,  Dihydroxydocosapentaenoic acids (DHDPs) ,  Rotenone ,  Parkinson’s disease

JST classification (4)： Metabolism in general  (EB05030X) ,  Enzyme physiology  (EJ02020P) ,  Metabolism and nutrition of lipids  (EJ02034Q) ,  Basic research of antiepileptics and anticonvulsants  (GW03060D)

Substance index (1)： Rotenone

Terms in the title (11)： パーキンソン病 ,  ロテノン ,  誘発 ,  ラット ,  モデル ,  脳 ,  DHA ,  補給 ,  チトクロームP450 ,  可溶性エポキシドヒドロラーゼ ,  ジオール