Art

J-GLOBAL ID：202102287749781210   Reference number：21A0099405

Aducanumab, gantenerumab, BAN2401, and ALZ-801-the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

Aducanumab,Gantenerumab,BAN2401およびALZ-801: 近期承認の可能性を有するアルツハイマー病に対するアミロイド標的薬剤の第一波【JST・京大機械翻訳】

Author (5)： Tolar Martin (Alzheon, Inc., Framingham, USA) ,  Abushakra Susan (Alzheon, Inc., Framingham, USA) ,  Hey John A. (Alzheon, Inc., Framingham, USA) ,  Porsteinsson Anton (University of Rochester School of Medicine and Dentistry, Rochester, USA) ,  Sabbagh Marwan (Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, USA)
Material： Alzheimer's Research & Therapy (Web)
Volume： 12  Issue： 1  Page： 1-10  Publication year： 2020 
JST Material Number： U7297A  ISSN： 1758-9193  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： The body of evidence suggestin...

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Thesaurus term： blood vessel ,  plasma(blood) ,  *amyloid ,  clearance ,  antibody ,  image processing ,  oligomer ,  plaque ,  small molecule ,  *Alzheimer disease ,  phase 3 study ,  biomarker ,  pathogenesis ,  amyloid beta-protein ,  amyloid plaque

Author keywords (9)： Alzheimer’s disease ,  Beta amyloid oligomers ,  Anti-oligomer agents ,  Anti-amyloid antibodies ,  APOE4 genotype ,  Aducanumab ,  Gantenerumab ,  BAN2401 ,  ALZ-801

JST classification (2)： Neurologic diagnosis  (GN02000H) ,  Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y)

Reference (52)：

• Tolar M, Abushakra S, Sabbagh M. The path forward in Alzheimer’s disease therapeutics: reevaluating the amyloid cascade hypothesis. Alzheimers Dement 2019;1-8. https://doi.org/10.1016/j.jalz.2019.09.075.
• Acta Neuropathol; Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis; KL Viola, W Klein; 129; 2; 2015; 183-206; 10.1007/s00401-015-1386-3; citation_id=CR2
• J Prev Alz Dis; A is for amyloid; DJ Selkoe; 3; 7; 2020; 140-141; citation_id=CR3
• Acta Neuropathol; Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain; W Hong, Z Wang, W Liu, TT O’Malley, M Jin, M Willem; 136; 1; 2018; 19-40; 10.1007/s00401-018-1846-7; citation_id=CR4
• Exp Neurol; Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model; RC Gaspar, SA Villarreal, N Bowles, RW Hepler, JG Joyce, P Shugrue; 223; 2; 2010; 394-400; 10.1016/j.expneurol.2009.09.001; citation_id=CR5

Terms in the title (7)： 承認 ,  可能性 ,  アルツハイマー ,  アミロイド ,  標的 ,  薬剤 ,  第一波