Rchr
J-GLOBAL ID：200901044210527694
Update date: Jan. 30, 2024
NAOYUKI KOTOKU
コトク ナオユキ | NAOYUKI KOTOKU
Affiliation and department：
Job title：
Associate Professor
Research field (4)：
Environmental and pharmaceutical development resources
, Pharmaceuticals - chemistry and drug development
, Chemical biology
, Molecular biochemistry
Research keywords (1)：
Synthetic organic chemistry, Natural Products chemistry, Medicinal chemistry, Chemical biology
Research theme for competitive and other funds (21)：
- 2022 - 2025 海洋天然物を起点とする膵臓ガン選択的増殖阻害剤の創製と薬剤耐性メカニズム解明
- 2021 - 2024 接着分子内在化を機序とする抗体創薬の基礎研究
- 2018 - 2022 Mechanistic studies of tumor cell growth using marine natural product and its application for anti-tumor drug discovery
- 2017 - 2019 統合的戦略に基づく新規PPI阻害剤の創製
- 2015 - 2018 Medicinal chemistry study of bioactive marine natural products targeting tumor microenvironment
- 2015 - 2018 Exploring new drug targets based on binding protein identification of bioactive natural products
- 2014 - 2018 Creation of novel molecular-targeted anticancer drugs focused on specific phenotypic changes of cells in tumor
- 2013 - 2016 Target identification of cortistatin A and development of anti-cancer drug lead
- 2011 - 2016 Search for medicinal seeds and analysis of their target molecules
- 2015 - 2016 海洋天然物を基軸とした新規抗がん剤リード化合物の合理的構築
- 2014 - 2015 創薬を指向した天然物ケミカルバイオロジー
- 2013 - 2015 Development of short-step synthesis of probe molecules for accelerating target identification
- 2010 - 2015 Search for molecular-targeted anti-cancer agents acting on the microenvironment in tumor and analysis of their target molecules
- 2009 - 2012 海洋天然物由来のガン細胞制御分子の開拓とその作用メカニズムの解明
- 2006 - 2009 Search for Bioactive Natural Products for Molecular Target Chemotherapy of Cancer
- 2006 - 2008 分子標的戦略に基づく抗がん天然物質の探索
- 2007 - 2008 Synthetic studies of marine natural products having anti-angiogenic activities
- 2006 - 2007 抗がんリード化合物としての新規血管新生阻害剤の創生
- 2004 - 2007 海洋生物由来の医薬シーズとしての生体機能分子の探索
- 2005 - 2006 血管新生を標的とする新規抗がんリード化合物の創製
- 2000 - 2002 多連続不斉中心の新規構築法の開発:Stemonaアルカロイドの不斉合成研究
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Papers (53)：
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Yuji Sumii, Kentaro Kamiya, Takehiko Nakamura, Kenta Tanaka, Takumi Kaji, Junya Mukomura, Naoyuki Kotoku, Masayoshi Arai. Study of the Structure-Activity Relationship of an Anti-Dormant Mycobacterial Substance 3-(Phenethylamino)Demethyl(oxy)aaptamine to Create a Probe Molecule for Detecting Its Target Protein. Marine drugs. 2022. 20. 2
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Yuji Sumii, Naoyuki Kotoku, Chisu Han, Kentaro Kamiya, Andi Setiawan, Catherine Vilchèze, William R Jacobs Jr, Masayoshi Arai. 3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis. Tetrahedron letters. 2020. 61. 22
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Ryosuke Ishida, Hirokazu Matsumoto, Sayaka Ichii, Motomasa Kobayashi, Masayoshi Arai, Naoyuki Kotoku. Structure-Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-starved Condition from Marine Sponge. Chemical & Pharmaceutical Bulletin. 2019. 67. 3. 210-223
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Takashi Kawachi, Shun Tanaka, Akinori Fukuda, Yuji Sumii, Andi Setiawan, Naoyuki Kotoku, Motomasa Kobayashi, Masayoshi Arai. Target Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments. Marine Drugs. 2019. 17. 3. 163
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Naoyuki Kotoku, Aoi Ito, Shunichi Shibuya, Kanako Mizuno, Aki Takeshima, Masaki Nogata, Motomasa Kobayashi. Short-step synthesis and structure-activity relationship of cortistatin A analogs. TETRAHEDRON. 2017. 73. 10. 1342-1349
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MISC (4)：
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古徳直之, 戸田和成, 荒井雅吉, 石田良典, 松本紘和, 村岡修, 小林資正. グルコース飢餓環境選択的がん細胞増殖阻害作用を有する新規ポリケチド類の化学構造と生物活性. 天然有機化合物討論会講演要旨集(Web). 2014. 56th. 109-114(J-STAGE)
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荒井 雅吉, 河内 崇志, 古徳 直之, 遠藤 洋子, 井上 正宏, 小林 資正. 低酸素環境選択的がん細胞増殖阻害物質furospinosulin-1のin vivo評価. 日本生薬学会年会講演要旨集. 2013. 60回. 259-259
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Naoyuki Kotoku, Yuji Sumii, Motomasa Kobayashi. Stereoselective Synthesis of Core Structure of Cortistatin A. ORGANIC LETTERS. 2011. 13. 13. 3514-3517
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い宏, 伊藤卓也, 木下雅裕, 古徳直之, 小林資正. 海生真菌Emericella valiecolor GF10株由来のポリケタイドshimalactone Aの化学構造. 日本薬学会年会要旨集. 2005. 125th. 4
Patents (3)：
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抗がん物質のスクリーニング方法
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Preparation of cortistatin A-analog compounds for inhibiting vascular endothelial cell growth and angiogenesis
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Preparation of prenylarene compounds for use as anticancer agents
Lectures and oral presentations (6)：
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Synthetic study of novel analogs of arenastatin A
(139th Annual Meeting of the Pharmaceutical Society of Japan 2019)
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Synthesis and Mechanistic Studies of Biakamides, Naturally-occurring Anti-austerity Agents Targeting Mitochondria
(4th International Symposium for Medicinal Sciences (ISMS) 2018)
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海洋天然物を基盤とする潜在性結核菌に有効な新規抗菌剤シーズの合成
(第67回日本薬学会近畿支部総会・大会 2017)
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栄養飢餓環境選択的がん細胞増殖阻害活性物質biakamide類の合成研究と作用機序解析
(第59回天然有機化合物討論会 2017)
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有機合成化学を基盤とする海洋天然物のケミカルバイオロジー研究
(第37回有機合成若手セミナー「明日の有機合成を担う人のために」 2017)
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Education (3)：
- - 2003 Osaka University Graduate School of Pharmaceutical Sciences
- - 2000 Osaka University Graduate School of Pharmaceutical Sciences
- - 1998 Osaka University School of Pharmacy
Professional career (1)：
Work history (4)：
- 2017/04/01 - Associate Professor, College of Pharmaceutical Sciences, Ritsumeikan University
- 2007/04/01 - 2017/03/31 Assistant Professor, Graduate School of Pharmaceutical Sciences, Osaka University
- 2003/04/01 - 2007/03/31 Research Associate, School of Pharmacy, Osaka University
- 2000/04/01 - 2003/03/31 JSPS Research Fellow
Awards (3)：
- 2015/09 - 日本生薬学会 平成27年度日本生薬学会学術奨励賞
- 2013/01 - 日本薬学会近畿支部 平成24年度日本薬学会近畿支部奨励賞
- 2012/11 - 日本薬学会医薬化学部会 平成24年度日本薬学会メディシナルケミストリーシンポジウム優秀賞
Association Membership(s) (5)：
日本ケミカルバイオロジー学会
, 日本がん分子標的治療学会
, 有機合成化学協会
, 日本生薬学会
, 日本薬学会
