Art

J-GLOBAL ID：201902249110608812   Reference number：19A0768003

Structure-Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-Starved Condition from Marine Sponge

海洋性海綿動物からの栄養飢餓条件下での選択的成長阻害剤のビアカミドの構造活性相関

Author (6)： Ishida Ryosuke (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Matsumoto Hirokazu (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Ichii Sayaka (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Kobayashi Motomasa (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Arai Masayoshi (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Kotoku Naoyuki (Graduate School of Pharmaceutical Sciences, Osaka University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 67  Issue： 3  Page： 210-223(J-STAGE)  Publication year： 2019 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Porifera ,...
Semi thesaurus term： *PANC-1 cell ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A0768003&from=J-GLOBAL&jstjournalNo=U1401A") }}

Author keywords (10)： biakamide ,  nutrient starvation ,  analog synthesis ,  structure-activity relationship (SAR) ,  marine sponge ,  biakamide ,  nutrient starvation ,  analog synthesis ,  structure-activity relationship (SAR) ,  marine sponge

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Other natural substances of biological origin  (CF10090R)

Substance index (7)： Biakamide A ,  Biakamide B ,  Biakamide C ,  Biakamide D ,  (2E)-N,2-Dimethyl-N-(2-thiazolylmethyl)-9-[(E)-chloromethylene]-12-[methyl[(E)-3-methoxy-2-butenoyl]amino]-2-dodeceneamide ,  (2E,9E)-9-(chloromethylidene)-12-[(2E)-3-methoxy-N-methylbut-2-enamido]-2-methyl-N-(1,3-thiazol-2-ylmethyl)dodec-2-enamide ,  (2E)-12-[(2E)-3-methoxy-N-methylbut-2-enamido]-N,2-dimethyl-N-(1,3-thiazol-2-ylmethyl)dodec-2-enamide

Reference (11)：

• 1) Rohwer N., Cramer T., Drug Resist. Updat., 14, 191-201 (2011).
• 2) Chen S., Rehman S. K., Zhang W., Wen A., Yao L., Zhang J., Biochim. Biophys. Acta, 1806, 220-229 (2010).
• 3) Lu J., Kunimoto S., Yamazaki Y., Kaminishi M., Esumi H., Cancer Sci., 95, 547-552 (2004).
• 4) Awale S., Lu J., Kalauni S. K., Kurashima Y., Tezuka Y., Kadota S., Esumi H., Cancer Res., 66, 1751-1757 (2006).
• 5) Ikeda M., Sato A., Mochizuki N., Toyosaki K., Miyoshi C., Fujioka R., Mitsunaga S., Ohno I., Hashimoto Y., Takahashi H., Hasegawa H., Nomura S., Takahashi R., Yomoda S., Tsuchihara K., Kishino S., Esumi H., Cancer Sci., 107, 1818-1824 (2016).

Terms in the title (6)： 海洋 ,  海綿動物 ,  栄養飢餓 ,  選択的成長 ,  阻害剤 ,  構造活性相関