チャンヨンジエ

Zhang Yongjie

所属機関・部署：

研究分野 (1件)：医療薬学

研究キーワード (4件)：個人差 , 薬物代謝酵素 , 毒性学 , 薬物代謝

競争的資金等の研究課題 (1件)：

2019 - 2021 Characterization of human glutathione S-transferase P1-1-catalyzed glutathionylation of proteins: as a clue to understand the inter-individual difference in drug-induced toxicity

論文 (8件)：

Zhang Y, Wijaya L, Dekker SJ, Vermeulen NPE, Commandeur JNM. High-performance liquid chromatography-based assay for glutathione transferase theta 2 activity: Application to characterize interindividual variability in human liver fractions. Journal of pharmaceutical and biomedical analysis. 2018. 156. 181-188
den Braver-Sewradj SP, den Braver MW, Toorneman RM, van Leeuwen S, Zhang Y, Dekker SJ, Vermeulen NPE, Commandeur JNM, Vos JC. Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations. Chemical research in toxicology. 2018. 31. 2. 116-126
チャンヨンジエ. In vitro and cellular systems for the characterization of bioactivating and inactivating drug metabolizing enzymes in adverse drug reactions: Insights into amodiaquine idiosyncratic toxicity. Vrije Universiteit Amsterdam. 2018
den Braver-Sewradj SP, den Braver MW, van Dijk M, Zhang Y, Dekker SJ, Wijaya L, Vermeulen NPE, Richert L, Commandeur JNM, Vos JC. Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals. Current drug metabolism. 2018. 19. 4. 370-381
Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM, Vos JC. Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells. Frontiers in pharmacology. 2018. 9. 388

講演・口頭発表等 (1件)：

Evaluation of the protective effects of glutathione S-transferase P1 against the cytotoxicity of amodiaquine quinoneimine in HepG2 cells
(2017 FIGON Dutch Medicine Days 2017)

学歴 (1件)：

2013 - 2017 VU University Amsterdam Molecular and Computational Toxicology

所属学会 (1件)：

International Society for the Study of Xenobiotics

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