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J-GLOBAL ID：200902283011088248   整理番号：09A0453309

臨床的なイマチニブの長期効果は体格に影響を受けるイマチニブトラフ濃度と相関する: 長崎CML研究班の報告

Long-term efficacy of imatinib in a practical setting is correlated with imatinib trough concentration that is influenced by body size: a report by the Nagasaki CML Study Group

著者 (40件)： SAKAI Mari (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  MIYAZAKI Yasushi (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  MATSUO Emi (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  MORIUCHI Yukiyoshi (Nagasaki CML Study Group, Nagasaki, JPN) ,  HATA Tomoko (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  FUKUSHIMA Takuya (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  IMAIZUMI Yoshitaka (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  IMANISHI Daisuke (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  TAGUCHI Jun (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  IWANAGA Masako (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  TSUSHIMA Hideki (Nagasaki CML Study Group, Nagasaki, JPN) ,  INOUE Yoriko (Nagasaki CML Study Group, Nagasaki, JPN) ,  TAKASAKI Yumi (Nagasaki CML Study Group, Nagasaki, JPN) ,  TSUCHIYA Takeshi (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  KOMODA Minori (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  ANDO Koji (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  HORIO Kensuke (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  MORIWAKI Yuji (Nagasaki CML Study Group, Nagasaki, JPN) ,  TOMINAGA Shinya (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  ITONAGA Hidehiro (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  NAGAI Kazuhiro (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  TSUKASAKI Kunihiro (Nagasaki Univ. Graduate School of Biomedical Sci., Nagasaki, JPN) ,  TSUTSUMI Chizuko (Nagasaki CML Study Group, Nagasaki, JPN) ,  SAWAYAMA Yasushi (Nagasaki CML Study Group, Nagasaki, JPN) ,  YAMASAKI Reishi (Nagasaki CML Study Group, Nagasaki, JPN) ,  OGAWA Daisuke (Nagasaki CML Study Group, Nagasaki, JPN) ,  KAWAGUCHI Yasuhisa (Nagasaki CML Study Group, Nagasaki, JPN) ,  IKEDA Shuichi (Nagasaki CML Study Group, Nagasaki, JPN) ,  YOSHIDA Shinichiro (Nagasaki CML Study Group, Nagasaki, JPN) ,  ONIMARU Yasuyuki (Nagasaki CML Study Group, Nagasaki, JPN) ,  TAWARA Masayuki (Nagasaki CML Study Group, Nagasaki, JPN) ,  ATOGAMI Sunao (Nagasaki CML Study Group, Nagasaki, JPN) ,  KOIDA Satoshi (Nagasaki CML Study Group, Nagasaki, JPN) ,  JOH Tatsuro (Nagasaki CML Study Group, Nagasaki, JPN) ,  YAMAMURA Masaomi (Nagasaki CML Study Group, Nagasaki, JPN) ,  MATSUO Yuji (Nagasaki CML Study Group, Nagasaki, JPN) ,  SODA Hisashi (Nagasaki CML Study Group, Nagasaki, JPN) ,  NONAKA Hiroaki (Nagasaki CML Study Group, Nagasaki, JPN) ,  JINNAI Itsuro (Nagasaki CML Study Group, Nagasaki, JPN) ,  KURIYAMA Kazutaka (Nagasaki CML Study Group, Nagasaki, JPN)
資料名： International Journal of Hematology  (International Journal of Hematology)
巻： 89  号： 3  ページ： 319-325  発行年： 2009年04月 
JST資料番号： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： イマチニブは慢性骨髄性白血病(CML)患者の長期生存を劇的に...

シソーラス用語： *抗腫瘍薬 ,...
準シソーラス用語： *トラフ値 ,...

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分類 (3件)： 腫ようの薬物療法  (GE03032C) ,  血液の腫よう  (GK04000M) ,  抗腫よう薬の臨床への応用  (GW16020L)

物質索引 (1件)： イマチニブ

引用文献 (17件)：

• HEHLMANN, R. European Leukemia-Net. Chronic myeloid leukaemia. Lancet. 2007, 370, 342-350
• BORTHAKUR, G. Imatinib mesylate treat chronic myelogenous leukemia. Int J Hematol. 2004, 79, 411-419
• DEININGER, M. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood. 2005, 105, 2640-2653
• O'BRIEN, SG. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003, 348, 994-1004
• HUGHES, TM. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med. 2003, 349, 1423-1432

タイトルに関連する用語 (10件)： 臨床 ,  イマチニブ ,  長期効果 ,  体格 ,  トラフ濃度 ,  相関 ,  長崎 ,  CML ,  研究 ,  報告