文献

J-GLOBAL ID：201702275695024992   整理番号：17A0658416

腫瘍壊死因子αは核内因子-κB経路を通して内皮細胞特異的受容体Roundabout4の発現を誘導する

Tumor Necrosis Factor α Induces the Expression of the Endothelial Cell-Specific Receptor Roundabout4 through the Nuclear Factor-κB Pathway

著者 (11件)： Tanaka Toru (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Maekawa Naoki (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Kashio Taito (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Izawa Kohei (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Ishiba Ryosuke (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Shirakura Keisuke (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Ishimoto Kenji (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Hino Nobumasa (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Aird William C. (Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center) ,  Doi Takefumi (Graduate School of Pharmaceutical Sciences, Osaka University) ,  Okada Yoshiaki (Graduate School of Pharmaceutical Sciences, Osaka University)
資料名： Biological and Pharmaceutical Bulletin  (Biological and Pharmaceutical Bulletin)
巻： 40  号： 4  ページ： 504-509(J-STAGE)  発行年： 2017年 
JST資料番号： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： Roundabout4(Robo4)は血管安定性を調節する内...

シソーラス用語： マウス ,...
準シソーラス用語： Roundabout4

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著者キーワード (10件)： Roundabout4 ,  nuclear factor kappaB ,  tumor necrosis factor alpha ,  endothelial cell ,  inflammation ,  Roundabout4 ,  nuclear factor kappaB ,  tumor necrosis factor alpha ,  endothelial cell ,  inflammation

分類 (1件)： 生物学的機能  (EB03040U)

引用文献 (25件)：

• 1) Huminiecki L, Gorn M, Suchting S, Poulsom R, Bicknell R. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics, 79, 547-552 (2002).
• 2) Suchting S, Heal P, Tahtis K, Stewart LM, Bicknell R. Soluble robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration. FASEB J., 19, 121-123 (2005).
• 3) Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC. A three-kilobase fragment of the human robo4 promoter directs cell type-specific expression in endothelium. Circ. Res., 100, 1712-1722 (2007).
• 4) Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat. Med., 14, 448-453 (2008).
• 5) Yoshikawa M, Mukai Y, Okada Y, Tsumori Y, Tsunoda S, Tsutsumi Y, Aird WC, Yoshioka Y, Okada N, Doi T, Nakagawa S. Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-robo4 cell-internalizing antibody. Blood, 121, 2804-2813 (2013).

タイトルに関連する用語 (8件)： 腫瘍壊死因子α ,  核 ,  内因子 ,  経路 ,  内皮細胞 ,  受容体 ,  発現 ,  誘導