文献

J-GLOBAL ID：201802236403912328   整理番号：18A1010932

p62遺伝子およびNrf2遺伝子両方の欠失は非アルコール性脂肪肝炎を自然発症する

Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis

著者 (15件)： Akiyama Kentaro (Doctoral Programs in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Akiyama Kentaro (Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan) ,  Warabi Eiji (Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Okada Kosuke (Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Yanagawa Toru (Division of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Ishii Tetsuro (Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Kose Katsumi (Institute of Applied Physics, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8573, Japan) ,  Tokushige Katsutoshi (Institute of Gastroenterology Internal Medicine, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan) ,  Ishige Kazunori (Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Mizokami Yuji (Division of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Yamagata Kenji (Division of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Onizawa Kojiro (Division of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan) ,  Ariizumi Shun-ichi (Institute of Gastroenterology Surgery, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan) ,  Yamamoto Masakazu (Institute of Gastroenterology Surgery, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan) ,  Shoda Junichi (Medical Sciences, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan)
資料名： Experimental Animals  (Experimental Animals)
巻： 67  号： 2  ページ： 201-218(J-STAGE)  発行年： 2018年 
JST資料番号： Z0755A  ISSN： 1341-1357  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 非アルコール性脂肪性肝炎(NASH)は,世界的な慢性肝疾患の...

シソーラス用語： ノックアウトマウス ,...
準シソーラス用語： *免疫反応 ,...

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著者キーワード (5件)： 生活習慣病 ,  過食症 ,  腸管透過性 ,  リポ多糖 ,  多重並列HITS仮説

分類 (2件)： 消化器の基礎医学  (GH01020E) ,  免疫反応一般  (ED03010T)

引用文献 (47件)：

• 1. Baffy G. 2009. Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J. Hepatol. 51: 212-223.
• 2. Bedossa P. 2017. Pathology of non-alcoholic fatty liver disease. Liver Int. 37:(Suppl 1): 85-89.
• 3. Bugianesi E., Leone N., Vanni E., Marchesini G., Brunello F., Carucci P., Musso A., De Paolis P., Capussotti L., Salizzoni M., and Rizzetto M. 2002. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123: 134-140.
• 4. Chitturi S. and Farrell G.C. 2001. Etiopathogenesis of nonalcoholic steatohepatitis. Semin. Liver Dis. 21: 27-41.
• 5. Cong L., Ran F.A., Cox D., Lin S., Barretto R., Habib N., Hsu P.D., Wu X., Jiang W., Marraffini L.A., and Zhang F. 2013. Multiplex genome engineering using CRISPR/Cas systems. Science 339: 819-823.

タイトルに関連する用語 (6件)： p62 ,  遺伝子 ,  NRF2 ,  欠失 ,  非アルコール性脂肪肝炎 ,  自然発症