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J-GLOBAL ID：201802242655263878   整理番号：18A0193358

PVHにおけるAMPK調節されたCRHニューロンの活性化は十分及び脂肪に対する炭水化物のための誘導摂食し好に必要である【Powered by NICT】

Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat

著者 (38件)： Okamoto Shiki (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Okamoto Shiki (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Okamoto Shiki (Second Department of Internal Medicine (Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology), Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami-gun, Okinawa 903-0215, Japan) ,  Sato Tatsuya (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Sato Tatsuya (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Tateyama Michihiro (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Tateyama Michihiro (Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Kageyama Haruaki (Department of Nutrition, Faculty of Health Care, Kiryu University, 606-7 Kasakake-cho Azami, Midori, Gunma 379-2392, Japan) ,  Maejima Yuko (Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Nakata Masanori (Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Hirako Satoshi (Department of Health and Nutrition, University of Human Arts and Sciences, 1288 Magome, Iwatsuki-ku, Saitama-shi, Saitama 339-8539, Japan) ,  Matsuo Takashi (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Matsuo Takashi (Division of Neurology, Respirology, Endocrinology, and Metabolism, Department of Internal Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan) ,  Kyaw Sanda (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Kyaw Sanda (Department of Physiology, University of Medicine 1, Yangon, Myanmar) ,  Shiuchi Tetsuya (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Toda Chitoku (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Sedbazar Udval (Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Saito Kumiko (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Asgar Nur Farehan (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Asgar Nur Farehan (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Zhang Boyang (Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Yokota Shigefumi (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Kobayashi Kenta (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Kobayashi Kenta (Section of Viral Vector Development, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Foufelle Fabienne (Sorbonne Universites, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France) ,  Foufelle Fabienne (INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France) ,  Foufelle Fabienne (Universite Paris Descartes, Sorbonne Paris Cite, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France) ,  Ferre Pascal (Sorbonne Universites, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France) ,  Ferre Pascal (INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France) ,  Ferre Pascal (Universite Paris Descartes, Sorbonne Paris Cite, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France) ,  Nakazato Masamitsu (Division of Neurology, Respirology, Endocrinology, and Metabolism, Department of Internal Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan) ,  Masuzaki Hiroaki (Second Department of Internal Medicine (Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology), Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami-gun, Okinawa 903-0215, Japan) ,  Shioda Seiji (Division of Peptide Drug Innovation, Global Research Center for Innovative Life Science, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan) ,  Yada Toshihiko (Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan) ,  Kahn Barbara B. (Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA) ,  Minokoshi Yasuhiko (Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan) ,  Minokoshi Yasuhiko (Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan)
資料名： Cell Reports  (Cell Reports)
巻： 22  号： 3  ページ： 706-721  発行年： 2018年 
JST資料番号： W3124A  ISSN： 2211-1247  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 食品選択は代謝ホメオスタシスに必須であり,栄養状態,食物嗜好性,および社会的要因応力などによって影響される。しかし,高炭水化物食(H CD)間の選択と高脂肪食(HFD)の原因となる機構は未知のままである。ここでは,視床下部室傍核(PVH)の頭側領域では副腎皮質刺激ホルモン放出ホルモン(CRH)-陽性ニューロンのサブセットの活性化は絶食後再給餌中のマウスにおけるHFD上のH CDの選択を誘導し,ケトン代謝の変化からの速やかな回復をもたらすことを示した。これらのニューロンは絶食中のAMP活性化蛋白質キナーゼ(AMPK)の活性化を明らかにし,この活性化が必要であり,HFD上のH CDの選択に十分であった。さらに,この効果はカルニチンパルミトイルトランスフェラーゼ1c(CPT1c)により仲介される。このように,著者らの結果は,H CDとH FDの間の選択の複雑な挙動の調節に関与する特異的ニューロンと細胞内シグナル伝達経路を同定した。ヌル表示省略Copyright 2018 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *ニューロン ,  高脂肪食 ,  室傍核 ,  ホメオスタシス ,  栄養状態 ,  食品 ,  CRH【ホルモン】 ,  ケトン ,  代謝 ,  絶食
準シソーラス用語： 細胞内シグナル伝達 ,  再給餌 ,  高炭水化物食 ,  食物嗜好性 ,  *AMP活性化蛋白質キナーゼ , 【Automatic Indexing@JST】

著者キーワード (5件)： 食し好 ,  AMPK ,  CRH ,  PVH ,  CPT1c

分類 (1件)： 代謝異常・栄養性疾患一般  (GD05010J)

タイトルに関連する用語 (10件)： AMPK ,  調節 ,  CRH ,  ニューロン ,  活性化 ,  脂肪 ,  炭水化物 ,  誘導 ,  摂食 ,  し好