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J-GLOBAL ID：201902210767101309   整理番号：19A2287634

メラトニンは宇宙飛行中の骨損失の予防のための有望な薬剤である【JST・京大機械翻訳】

Melatonin is a potential drug for the prevention of bone loss during space flight

著者 (53件)： Ikegame Mika (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan) ,  Hattori Atsuhiko (College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan) ,  Tabata Makoto J. (Graduate School of Tokyo Medical and Dental University, Bunkyo-ku, Japan) ,  Kitamura Kei-ichiro (Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kodatsuno, Japan) ,  Tabuchi Yoshiaki (Life Science Research Center, University of Toyama, Toyama, Japan) ,  Furusawa Yukihiro (Department of Liberal Arts and Sciences, Toyama Prefectural University, Toyama, Japan) ,  Maruyama Yusuke (College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan) ,  Yamamoto Tatsuki (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan) ,  Sekiguchi Toshio (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan) ,  Matsuoka Risa (College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan) ,  Hanmoto Taizo (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan) ,  Ikari Takahiro (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan) ,  Endo Masato (Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Minato-ku, Japan) ,  Omori Katsunori (Faculty of Economics, Asia University, Musashino, Japan) ,  Nakano Masaki (College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan) ,  Yashima Sayaka (College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan) ,  Ejiri Sadakazu (Division of Oral Structure, Function and Development, Asahi University School of Dentistry, Mizuho, Japan) ,  Taya Toshiki (Agilent Technologies Japan Ltd., Hachioji, Japan) ,  Nakashima Hiroshi (Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kodatsuno, Japan) ,  Shimizu Nobuaki (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan) ,  Nakamura Masahisa (Faculty of Education and Integrated Arts and Sciences, Waseda University, Shinjuku-ku, Japan) ,  Kondo Takashi (Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan) ,  Hayakawa Kazuichi (Low Level Radioactivity Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Nomi, Japan) ,  Takasaki Ichiro (Graduate School of Science and Engineering, University of Toyama, Toyama, Japan) ,  Kaminishi Atsushi (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan) ,  Akatsuka Ryosuke (College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan) ,  Sasayama Yuichi (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan) ,  Nishiuchi Takumi (Institute for Gene Research, Advanced Science Research Center, Kanazawa University, Kanazawa, Japan) ,  Nara Masayuki (College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Japan) ,  Iseki Hachiro (Graduate School of Tokyo Medical and Dental University, Bunkyo-ku, Japan) ,  Chowdhury Vishwajit S. (Faculty of Arts and Science, Kyushu University, Fukuoka, Japan) ,  Wada Shigehito (Faculty of Medicine, University of Toyama, Toyama, Japan) ,  Ijiri Kenichi (Radioisotope Center, University of Tokyo, Bunkyo-ku, Japan) ,  Takeuchi Toshio (Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Minato-ku, Japan) ,  Suzuki Tohru (Graduate School of Agricultural Science, Tohoku University, Sendai, Japan) ,  Ando Hironori (Marine Biological Station, Sado Center for Ecological Sustainability, Niigata University, Sado, Japan) ,  Matsuda Kouhei (Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan) ,  Somei Masanori (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan) ,  Mishima Hiroyuki (Department of Dental Engineering, Tsurumi University School of Dental Medicine, Yokohama, Japan) ,  Mikuni-Takagaki Yuko (Kanagawa Dental University Graduate School of Dentistry, Yokosuka, Japan) ,  Funahashi Hisayuki (Department of Physical Therapy, Faculty of Makuhari Human Care, Tohto University, Mihama-ku, Japan) ,  Takahashi Akihisa (Gunma University Heavy Ion Medical Center, Maebashi, Japan) ,  Watanabe Yoshinari (Organization of Frontier Science and Innovation, Kanazawa University, Kanazawa, Japan) ,  Maeda Masahiro (Molecular Devices Japan Ltd., Chuo-ku, Japan) ,  Uchida Hideaki (Agilent Technologies Japan Ltd., Hachioji, Japan) ,  Hayashi Akio (Agilent Technologies Japan Ltd., Hachioji, Japan) ,  Kambegawa Akira (Kambegawa Laboratory, Komae, Japan) ,  Seki Azusa (HAMRI Co. Ltd., Koga, Japan) ,  Yano Sachiko (Japan Aerospace Exploration Agency, Tsukuba, Japan) ,  Shimazu Toru (Japan Space Forum, Chiyoda-ku, Japan) ,  Suzuki Hiromi (Japan Space Forum, Chiyoda-ku, Japan) ,  Hirayama Jun (Department of Clinical Engineering, Faculty of Health Sciences, Komatsu University, Komatsu, Japan) ,  Suzuki Nobuo (Division of Marine Environmental Studies, Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Japan)
資料名： Journal of Pineal Research  (Journal of Pineal Research)
巻： 67  号： 3  ページ： e12594  発行年： 2019年 
JST資料番号： W2656A  ISSN： 0742-3098  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 宇宙飛行中の微小重力条件のために,宇宙飛行士は骨量の骨粗鬆症様損失を経験する。骨損失を予防するために,それらはリスクのない抗吸収薬を必要とする。メラトニンは破骨細胞機能を抑制することが報告されている。しかし,微小重力条件下での骨代謝に及ぼすメラトニンの影響を調べた研究はない。著者らは,共存する破骨細胞と骨芽細胞の骨モデルとしてキンギョ鱗を用い,メラトニン合成に必須の酵素であるアセチルセロトニンO-メチルトランスフェラーゼのmRNA発現レベルが微小重力下で有意に減少することを示した。宇宙飛行中,微小重力は破骨細胞活性を刺激し,破骨細胞分化と活性化に対する遺伝子発現を有意に増加させた。メラトニン処理は,破骨細胞機能に対する抑制された遺伝子発現レベルと一致する,カルcit(破骨細胞阻害ホルモン)mRNA発現を有意に刺激し,核因子κBリガンド(破骨細胞形成のプロモーター)の受容体活性化因子のmRNA発現を低下させた。これは微小重力による破骨細胞活性化に対するメラトニンの阻害効果を報告する最初の研究である。また,カルシトニン分泌の増加により,破骨細胞に対するメラトニンの新しい作用経路を観察した。メラトニンは,宇宙飛行中の骨損失を防ぐための潜在的な新薬の供給源となり得る。Copyright 2019 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 骨粗鬆症 ,  微小重力 ,  骨芽細胞 ,  破骨細胞 ,  カルシトニン ,  プロモーター領域 ,  新薬 ,  *宇宙飛行 ,  遺伝子発現 ,  骨密度 ,  骨代謝 ,  キンギョ ,  骨細胞 ,  mRNA発現 ,  分子遺伝現象 ,  脂肪酸 ,  窒素複素環化合物 ,  カルボアミド ,  フェノールエーテル ,  芳香族縮合化合物

著者キーワード (6件)： カルシトニン ,  魚の鱗 ,  微小重力 ,  骨細胞 ,  破骨細胞 ,  RANKL

分類 (1件)： 生殖器官  (EJ15020P)

物質索引 (1件)： メラトニン

タイトルに関連する用語 (5件)： メラトニン ,  宇宙飛行 ,  骨損失 ,  予防 ,  薬剤