文献

J-GLOBAL ID：201902232025537149   整理番号：19A0325352

非侵襲性出生前検査(NIPT)の非レポーター的結果に関与する因子の分類と第2NIPTの成功率の予測【JST・京大機械翻訳】

Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT

著者 (58件)： Suzumori Nobuhiro (Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Suzumori Nobuhiro (Division of Clinical and Molecular Genetics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Sekizawa Akihiko (Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan) ,  Takeda Eri (Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Takeda Eri (Division of Clinical and Molecular Genetics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Samura Osamu (Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan) ,  Sasaki Aiko (Division of Fetal Medicine, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan) ,  Akaishi Rina (Division of Fetal Medicine, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan) ,  Wada Seiji (Division of Fetal Medicine, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan) ,  Hamanoue Haruka (Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan) ,  Hirahara Fumiki (Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan) ,  Kuriki Hiroko (Department of Clinical Genetics, Yokohama City University Hospital, Yokohama, Japan) ,  Sawai Hideaki (Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Japan) ,  Nakamura Hiroaki (Department of Obstetrics, Osaka City General Hospital, Osaka, Japan) ,  Yamada Takahiro (Clinical Genetics Unit, Kyoto University Hospital, Kyoto, Japan) ,  Miura Kiyonori (Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan) ,  Masuzaki Hideaki (Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan) ,  Yamashita Takahiro (Department of Obstetrics and Gynecology, Maternal and Child Health Center, Aiiku Hospital, Tokyo, Japan) ,  Kamei Yoshimasa (Departments of Obstetrics and Gynecology, Saitama Medical University School of Medicine, Saitama, Japan) ,  Namba Akira (Departments of Obstetrics and Gynecology, Saitama Medical University School of Medicine, Saitama, Japan) ,  Murotsuki Jun (Department of Maternal and Fetal Medicine, Tohoku University Graduate School of Medicine, Miyagi Children’s Hospital, Sendai, Japan) ,  Tanemoto Tomohiro (Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan) ,  Fukushima Akimune (Department of Clinical Genetics, School of Medicine, Iwate Medical University, Morioka, Japan) ,  Haino Kazufumi (Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, Niigata, Japan) ,  Tairaku Shinya (Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Matsubara Keiichi (Department of Obstetrics and Gynecology, Ehime University School of Medicine, Matsuyama, Japan) ,  Maeda Kazutoshi (Department of Obstetrics and Gynecology, Shikoku Medical Center for Children and Adults, Kagawa, Japan) ,  Kaji Takashi (Department of Obstetrics and Gynecology, The University of Tokushima Faculty of Medicine, Tokushima, Japan) ,  Ogawa Masanobu (Department of Obstetrics and Gynecology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan) ,  Osada Hisao (Department of Gynecology, Chiba University Graduate School of Medicine, Chiba, Japan) ,  Nishizawa Haruki (Department of Obstetrics and Gynecology, Fujita Health University, Aichi, Japan) ,  Okamoto Yoko (Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan) ,  Kanagawa Takeshi (Department of Obstetrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan) ,  Kakigano Aiko (Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Endo Masayuki (Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan) ,  Kitagawa Michihiro (Department of Obstetrics and Gynecology, Sanno Hospital, Tokyo, Japan) ,  Ogawa Masaki (Division of Obstetrics, Perinatal Medical Center, Tokyo Women’s Medical University Hospital, Tokyo, Japan) ,  Izumi Shunichiro (Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan) ,  Katagiri Yukiko (Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Takeshita Naoki (Department of Obstetrics and Gynecology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan) ,  Kasai Yasuyo (Department of Obstetrics and Gynecology, Japanese Red Cross Medical Center, Tokyo, Japan) ,  Naruse Katsuhiko (Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan) ,  Neki Reiko (Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, Osaka, Japan) ,  Masuyama Hisashi (Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Okayama, Japan) ,  Hyodo Maki (Department of Obstetrics and Gynecology, Hiroshima University Graduate School of Medicine, Hiroshima, Japan) ,  Kawano Yukie (Department of Molecular Pathology, Faculty of Medicine, Oita University, Oita, Japan) ,  Ohba Takashi (Department of Obstetrics and Gynecology, Kumamoto University, Kumamoto, Japan) ,  Ichizuka Kiyotake (Department of Obstetrics and Gynecology, Showa University Northern Yokohama Hospital, Yokohama, Japan) ,  Nagamatsu Takeshi (Departments of Obstetrics and Gynecology, Tokyo University Hospital, Tokyo, Japan) ,  Watanabe Atsushi (Division of Clinical Genetics, Nippon Medical School Hospital, Tokyo, Japan) ,  Nishikawa Naomi (Division of Clinical Genetics, Nagoya City West Medical Center, Nagoya, Japan) ,  Hamajima Naoki (Division of Clinical Genetics, Nagoya City West Medical Center, Nagoya, Japan) ,  Shirato Nahoko (Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan) ,  Yotsumoto Junko (Departments of Genetic Counseling, Ochanomizu University, Tokyo, Japan) ,  Nishiyama Miyuki (Division of Fetal Medicine, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan) ,  Koide Keiko (Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan) ,  Hirose Tatsuko (Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan) ,  Sago Haruhiko (Division of Fetal Medicine, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan)
資料名： Prenatal Diagnosis  (Prenatal Diagnosis)
巻： 39  号： 2  ページ： 100-106  発行年： 2019年 
JST資料番号： W2726A  ISSN： 0197-3851  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 目的:非報告性無細胞DNA(cfDNA)の非侵襲的出生前検査(NIPT)結果を評価するために,母親の特徴と結果に関連する他の詳細を遡及的に検討した。方法:2013年4月~2017年3月の間に,失敗したcfDNA試験を伴う大規模並列配列決定(MPS)によりNIPTを受けている妊婦における多施設遡及コホート研究を実施した。女性のデータとMPS結果を,母親の特性,試験成績,胎児分画(FF),zスコア,抗凝固療法,および非報告例の他の詳細に関して分析した。結果:全体として,34626人の妊婦のうち110人(0.32%)は,最初の血液サンプリング後に,非報告のcfDNA試験結果を示した。22人(20.0%)は低FF(<4%)を有し,18人(16.4%)は母親悪性腫瘍を含み,ゲノムプロファイルを変化させた。非報告の結果を有する症例の約半分は,境界zスコアを有した。ゲノムプロファイルの変化のために,非報告の結果を有する女性の間で,第2の血液サンプリングを用いた再試験の成功率は比較的低かった(25.0%~33.3%)。非報告の結果を有する女性の13人(11.8%)は,皮下ヘパリン注射を必要とした。結論:cfDNA分析を用いた非報告可能な結果の分類は,正確な情報を持つ女性を提供し,妊娠中の不安を減少させるために重要である。Copyright 2019 Wiley Publishing Japan K.K. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 胎児 ,  妊娠 ,  女性 ,  抗凝固療法 ,  ヒト ,  症例報告 ,  ゲノム ,  *妊婦 ,  コホート研究 ,  注射 ,  無細胞DNA ,  *成功率 ,  *出生 ,  薬物療法
準シソーラス用語： 悪性腫瘍 ,  スコア ,  *母体血胎児染色体検査 ,  非侵襲 , 【Automatic Indexing@JST】

分類 (1件)： 婦人科・産科の診断  (GS02000W)

タイトルに関連する用語 (7件)： 非侵襲性 ,  検査 ,  NIPT ,  因子 ,  分類 ,  成功率 ,  予測