Rchr
J-GLOBAL ID：200901000817516252   Update date: Sep. 10, 2024

Hamada Yoshio

ハマダ ヨシオ | Hamada Yoshio
Affiliation and department：
Konan University Graduate School of Frontiers of Innovative Research in Science and Technology

About Konan University Graduate School of Frontiers of Innovative Research in Science and Technology


Job title： Senior Researcher
Homepage URL  (1)： https://sites.google.com/site/pynden/
Research field  (1)： Pharmaceuticals - chemistry and drug development
Research keywords  (10)： 分子設計 ,  創薬科学 ,  天然物化学(全合成) ,  有機合成化学 ,  ペプチド合成 ,  AIDS ,  Alzheimer's disease ,  Drug design ,  Organic synthesis ,  Peptide synthesis
Research theme for competitive and other funds  (5)：
  • 2021 - 2024 接着分子内在化を機序とする抗体創薬の基礎研究
  • 2021 - 2024 Evaluation method of skin sensitization using chromophore-based solid phase peptide reaction assay in vitro.
  • 2018 - 2023 Design of beta- and eta-secretase inhibitors for the treatment of Alzheimer's disease
  • 2014 - 2016 アルツハイマー病克服を目指したアミロイド凝集およびBACE1の阻害剤開発
  • 2011 - 2013 アルツハイマー病克服のための統合的創薬研究
Papers (17)：
  • Keisuke Shimizu, Batsaikhan Mijiddorj, Masataka Usami, Ikuro Mizoguchi, Shuhei Yoshida, Shiori Akayama, Yoshio Hamada, Akifumi Ohyama, Kenji Usui, Izuru Kawamura, et al. De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide. Nature Nanotechnology. 2022. 17. 1. 67-75
  • Hiroshi Miyazaki, Hikaru Takaishi, Hidefumi Ikeda, Hideto Ariumi, Yoshio Hamada, Kunihiko Yamashita, Kenji Usui. Synthesis of peptide-immobilized magnetic beads, and peptide reactivity assay for assessing skin sensitization utilizing chromophore. Processes. 2020. 8. 10. 1-10
  • Kenji Usui, Shin-Ichiro Yokota, Kazuya Iwata, Yoshio Hamada. Novel purification process for amyloid beta peptide(1-40). Processes. 2020. 8. 4
  • Yoshio Hamada, Zyta M. Ziora. Peptidomimetic Synthesis: Drug Discovery for Alzheimer’s Disease. Methods in Molecular Biology. 2020. 215-223
  • Yoshio Hamada. Isoacylpeptide Method for Long-Chain and Difficult Sequence-Containing Peptide Preparation. Peptide Synthesis. 2019
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MISC (81)：
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Patents (18)：
  • 新規なオリゴ糖の製造方法
  • マルトオリゴ糖誘導体の製造方法
  • p-ニトロフェノール誘導体をアグリコンとする配糖体の製造方法
  • マルトオリゴ糖誘導体の製造法
  • マルトオリゴ糖誘導体およびその製造法
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Lectures and oral presentations  (68)：
  • A novel N-terminal Degradation Reaction of Peptide via Guanidine Derivatives
    (34th European Peptide Symposium 2016)
  • The significance of protein structure data set choices for in-silico drug discovery: Design of BACE1 inhibitors
    (International Symposium on Compound Design Technologies: Guiding Better Decisions in Drug Discovery and Development 2014)
  • Design of Small-Sized Peptides with BACE1 inhibitory activity
    (23th American Peptide Symposium 2013)
  • 分子認識を基盤とした創薬研究 ~ BACE1阻害剤の開発
    (生命分子機能研究会セミナー2013 「生命分子を基盤とする創薬科学」 2013)
  • Design and Synthesis of small BACE1 inhibitor peptides
    (32th European Peptide Symposium 2012)
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Works (1)：
  • 私が設計・合成したアルツハイマー病発症のメカニズム研究用に有用であるBACE1阻害剤を和光純薬工業(株)から試薬として発売した。
    2011 -
Education (6)：
  • - 2004 Kyoto Pharmaceutical University Graduate School of Pharmaceutical Sciences
  • - 1983 The University of Tokushima
  • - 1983 The University of Tokushima Graduate School, Division of Pharmaceutical Sciences
  • Kyoto Pharmaceutical University Pharmaceutical Sciences Pharmacy
  • Kyoto Pharmaceutical University Faculty of Pharmaceutical Science
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Professional career (1)：
  • Ph D. (The University of Tokushima)
Work history (9)：
  • 2016/04 - 現在 Konan University Facultyl of Frontiers of Innovative Research in Science and Technology Senior Researcher
  • 2014/04 - 2015/03 Kobe Pharmaceutical University
  • 2006 - 2009 Kyoto Pharmaceutical University
  • 1997 - 2000 富士写真フイルム(株)および旭化成(株)の創薬研究部門において研究コンサルタント(富士写真フイルム(株)では研究チームリーダーを兼務)
  • 1988 - 1997 Toyobo Co., Ltd.
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Awards (3)：
  • 2010 - Elsevier Bioorganic & Medicinal Chemistry Letters Most Cited Paper 2006-2009 Award
  • 2009 - Elsevier Bioorganic & Medicinal Chemistry Letters Most Cited Paper 2005-2008 Award
  • 2008 - Elsevier Bioorganic & Medicinal Chemistry Letters Most Cited Paper 2004-2007 Award
Association Membership(s) (4)：
日本ケミカルバイオロジー学会 ,  日本病態プロテアーゼ学会 ,  日本ペプチド学会 ,  日本薬学会
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