Research theme for competitive and other funds (45)：
2023 - 2027 Study of the instability among mutant epithelial cells, adjacent normal epithelial cells and stromal cells to develop strategies for screening and very early detection of cancer.
2023 - 2027 口腔細胞診における遺伝子検査法(GSC)の創出とその臨床応用
2021 - 2024 早期癌に認められる異型におけるHippo-YAPシグナルの機能解析
2021 - 2023 Analysis of new regulatory mechanism of protein deamidation and it's functional using oral cancer cells
2020 - 2023 Functional analysis and development of novel adenoid cystic carcinoma therapy targeting Wnt signaling
2020 - 2023 Analysis of the signal pathways between oral squamous cell carcinoma cells and surrounding microenvironment as novel therapeutic target for novel anti-cancer therapy
2019 - 2022 A new anti-cancer therapeutic strategy targeting the interrelation between tumorous mechanical extracellular microenvironment and novel oncogene-related gene signaling
2018 - 2021 Novel treatment strategy targeting key regulators of cancer microenvironment formation
2017 - 2021 Mechanism of tooth development based on mechanosensor
2016 - 2020 Involvement of glucose regulated protein 78 in the enamel formation of mouse tooth development
2016 - 2020 Enamel hypomineralization in mechano-sensitive ion channel deficiency mice
2016 - 2019 Investigation of the effect of the tissue microenvironment on tumor cells through TRPV4 channel
2016 - 2019 Junctional epithelial barrier in gingiva and periodontal diseases
2015 - 2019 The study of tissue engineering utilizing periodontal ligament stem cell induced by tropic factors
2015 - 2017 Study of the non-cord RNA-RNA Interaction Network in Oral Squamous Cell Carcinoma for anticancer therapy
2014 - 2017 Novel anticancer therapy targeting specific genes for squamous cell carcinoma
2013 - 2016 Study for the tumor suppressor network through STAT3 regulation in drug-resistance of oral squamous cell carcinoma
2013 - 2016 A study of cellular signaling of PP2A inhibitor during the tooth development
2013 - 2014 変異型DCC遺伝子を利用した口腔癌細胞のアポトーシス誘導
2011 - 2013 Study for establishment of odontogenic stem cells by regulation of gene "X" expression.
2011 - 2012 Study for therapeutic strategy using the target protein expressionsystem based on protein stabilization/destabilization in the cancertracing mechanism
2009 - 2011 Functional analysis for molecular networks of thymosin beta 4 in developing tooth germ.
2008 - 2011 Functional analysis for molecular interaction through a new member of the immunoglobulin superfamily in tooth germ development
2004 - 2005 Functional Analyses of new genes involved in tooth germ development
2003 - 2005 Epigenetic effect of HP1 on carcinoma cell tumorigenecity
2002 - 2004 器官培養法を用いた歯胚幹細胞の単離・同定と歯牙再生への応用
1998 - 2001 Mutational changes of EGFR mRNA in oral cancers and functions of a candidate tumor suppressor, doc-1
1997 - 2000 Morphological and molecular biological investigations on the relationship between tumor-related gene alteration, and the generation and growth of oral cancer.
1997 - 1998 歯牙発生過程における細胞応答の変化と細胞増殖因子のシグナル伝達経路について
1996 - 1996 顎関節滑膜表層細胞の発生と配列過程および病的状態における形態的・機能的変化
1995 - 1996 Pathological and molecular biological Investigations on the mechanism of generation, proliferation and metastasis of Oral Squamou Cell Carcinoma.
1996 - 歯牙発生過程における細胞応答の変化と各種因子のシグナル伝達経路の研究
1996 - Study on the cell responce and signal transduction of factors in the tooth development.
1995 - 1995 顎関節滑膜表層細胞の発生と分布、およびその機能について
1995 - 遺伝子導入による癌細胞の浸潤・転移能の変化についての研究
1995 - ヒト固形腫瘍における浸潤・転移メカニズムの解明
1995 - Study on the invasive and metastatic potentials in the transfected human malignant cells
1994 - Study on the mechanism of invasion and metastasis of human solid tumor
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Papers (117)：
Yusuke Nakako, Kana Hasegawa, Shinsuke Fujii, Yukiko Kami, Taiki Sakamoto, Mizuki Sakamoto, Masafumi Moriyama, Kari J Kurppa, Kristiina Heikinheimo, Kazunori Yoshiura, et al. Wnt/β-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst. Pathology, research and practice. 2024. 260. 155420-155420
Ryoko Nagano, Yusuke Nakako, Shinsuke Fujii, Shintaro Kawano, Hidefumi Maeda, Tamotsu Kiyoshima. The IL-1β-p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF-β signalling to promote cell proliferation of the lining epithelia in radicular cysts: A laboratory investigation. International endodontic journal. 2024. 57. 3. 344-354
Shinsuke Fujii, Kana Hasegawa, Takashi Maehara, Kari J Kurppa, Kristiina Heikinheimo, Kristy A. Warner, Satoshi Maruyama, Yudai Tajiri, Jacques E. Nör, Jun-ichi Tanuma, et al. Wnt/β-catenin-C-kit axis may play a role in adenoid cystic carcinoma prognostication. Pathology - Research and Practice. 2024. 155148-155148
Yuka Miyahara, Hu Chen, Masafumi Moriyama, Keita Mochizuki, Naoki Kaneko, A S M Rafiul Haque, Akira Chinju, Kazuki Kai, Mizuki Sakamoto, Noriko Kakizoe-Ishiguro, et al. Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K. Scientific reports. 2023. 13. 1. 19320-19320
Thinh Thi Kim Truong, Shinsuke Fujii, Ryoko Nagano, Kana Hasegawa, Megumi Kokura, Yuta Chiba, Keigo Yoshizaki, Satoshi Fukumoto, Tamotsu Kiyoshima. Arl4c is involved in tooth germ development through osteoblastic/ameloblastic differentiation. Biochemical and biophysical research communications. 2023. 679. 167-174
- 1994 Kyushu University Graduate School, Division of Dental Research
- 1990 Kyushu University School of Dentistry
- 1990 Kyushu University Faculty of Dentistry
Professional career (1)：
D.D.S., Ph.D. (Kyushu University)
Work history (10)：
2014/04 - 現在 Kyushu University Faculty of Dental Science
2012/10 - 2014/03 Kyushu University Faculty of Dental Science
2010/10 - 2012/09 - 九州大学大学院歯学研究院 講師
2007 - - 九州大学大学院歯学研究院 助教
1994 - 2000 Kyushu University School of Dentistry
1994 - 2000 Kyushu University, Faculty of Dentistry,
2000 - - 九州大学大学院歯学研究院 助手
2000 - - Kyushu University,
Faculty of Dental Science,
Research Assistant
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Association Membership(s) (13)：
日本顎関節学会
, 日本口腔腫瘍学会
, 歯科基礎医学会
, 日本口腔外科学会
, THE JAPANESE SOCIETY OF ORAL PATHOLOGY
, 日本癌学会
, 日本病理学会
, The Japanese Society for the Temporomandibular joint
, The Japanese Association for Oral Biology
, The Japanese Society for Oral and Maxillofacial Surgeon
, The Japanese Society for Oral Pathology
, The Japanese Cancer Association
, The Japanese Society of Pathology
