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J-GLOBAL ID：200901003855059760 Update date: Mar. 19, 2025

Kiyoshima Tamotsu

キヨシマタモツ | Kiyoshima Tamotsu

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Affiliation and department：
Job title： assistat professor

Research field (3)： Oral medicine , Experimental pathology , Human pathology

Research keywords (18)： odontogenesis , development , tooth germ , SCC , trancription , promoter , invasion , metastasis , tumor behavior , odontogenesis , development , tooth germ , SCC , trancription , promoter , invasion , metastasis , tumor behavior

Research theme for competitive and other funds (47)：

2023 - 2027 Study of the instability among mutant epithelial cells, adjacent normal epithelial cells and stromal cells to develop strategies for screening and very early detection of cancer.
2023 - 2027 Study of the instability among mutant epithelial cells, adjacent normal epithelial cells and stromal cells to develop strategies for screening and very early detection of cancer.
2023 - 2027 口腔細胞診における遺伝子検査法(GSC)の創出とその臨床応用
2023 - 2026 Elucidation of differentiation regulating mechanism by SPARC-related factors expressed in the dental papilla, and attempt of tooth regeneration
2021 - 2024 早期癌に認められる異型におけるHippo-YAPシグナルの機能解析

2021 - 2023 Analysis of new regulatory mechanism of protein deamidation and it's functional using oral cancer cells

2020 - 2023 Functional analysis and development of novel adenoid cystic carcinoma therapy targeting Wnt signaling

2020 - 2023 Analysis of the signal pathways between oral squamous cell carcinoma cells and surrounding microenvironment as novel therapeutic target for novel anti-cancer therapy

2020 - 2023 歯原性間葉系幹細胞誘導因子の同定と歯の再生への応用

2020 - 2023 エナメル上皮腫を引き起こす新しい分子基盤の解明とがんゲノム医療に向けた臨床応用

2019 - 2022 A new anti-cancer therapeutic strategy targeting the interrelation between tumorous mechanical extracellular microenvironment and novel oncogene-related gene signaling

2018 - 2021 Novel treatment strategy targeting key regulators of cancer microenvironment formation

2017 - 2021 Mechanism of tooth development based on mechanosensor

2016 - 2020 Involvement of glucose regulated protein 78 in the enamel formation of mouse tooth development

2016 - 2020 Enamel hypomineralization in mechano-sensitive ion channel deficiency mice

2016 - 2019 Investigation of the effect of the tissue microenvironment on tumor cells through TRPV4 channel

2016 - 2019 Junctional epithelial barrier in gingiva and periodontal diseases

2015 - 2019 The study of tissue engineering utilizing periodontal ligament stem cell induced by tropic factors

2015 - 2017 Study of the non-cord RNA-RNA Interaction Network in Oral Squamous Cell Carcinoma for anticancer therapy

2014 - 2017 Novel anticancer therapy targeting specific genes for squamous cell carcinoma

2013 - 2016 Study for the tumor suppressor network through STAT3 regulation in drug-resistance of oral squamous cell carcinoma

2013 - 2016 A study of cellular signaling of PP2A inhibitor during the tooth development

2013 - 2014 変異型DCC遺伝子を利用した口腔癌細胞のアポトーシス誘導

2011 - 2013 Study for establishment of odontogenic stem cells by regulation of gene "X" expression.

2011 - 2012 Study for therapeutic strategy using the target protein expressionsystem based on protein stabilization/destabilization in the cancertracing mechanism

2009 - 2011 Functional analysis for molecular networks of thymosin beta 4 in developing tooth germ.

2008 - 2011 Functional analysis for molecular interaction through a new member of the immunoglobulin superfamily in tooth germ development

2009 - 2010 炎症性サイトカインシグナルSTATの扁平上皮癌におけるin vivo評価法の開発

2005 - 2008 Study of tumor-specific oncolysis and anti-tumor efficacy for oral squamous cell carcinoma using vectors with selective replication.

2006 - 2007 FUNCTIONAL RESEARCH FOR THYMOSIN BETA 4 IN TOOTH GERM DEVELOPMENT

2005 - 2007 IDENTIFICATION OF ODONTOGENIC STEM CELLAND ITS MOLECULAR MECHANISM OF PROLIFERATION AND DIFFERENTIATION.

2005 - 2006 扁平上皮癌標的分子の特異的発現機構に基づく個別化治療法の開発を目指した基礎的研究

2004 - 2005 Functional Analyses of new genes involved in tooth germ development

2003 - 2005 Epigenetic effect of HP1 on carcinoma cell tumorigenecity

2002 - 2004 器官培養法を用いた歯胚幹細胞の単離・同定と歯牙再生への応用

1998 - 2001 Mutational changes of EGFR mRNA in oral cancers and functions of a candidate tumor suppressor, doc-1

1997 - 2000 Morphological and molecular biological investigations on the relationship between tumor-related gene alteration, and the generation and growth of oral cancer.

1997 - 1998 歯牙発生過程における細胞応答の変化と細胞増殖因子のシグナル伝達経路について

1996 - 1996 顎関節滑膜表層細胞の発生と配列過程および病的状態における形態的・機能的変化

1995 - 1996 Pathological and molecular biological Investigations on the mechanism of generation, proliferation and metastasis of Oral Squamou Cell Carcinoma.

1996 - 歯牙発生過程における細胞応答の変化と各種因子のシグナル伝達経路の研究

1996 - Study on the cell responce and signal transduction of factors in the tooth development.

1995 - 1995 顎関節滑膜表層細胞の発生と分布、およびその機能について

1995 - 遺伝子導入による癌細胞の浸潤・転移能の変化についての研究

1995 - ヒト固形腫瘍における浸潤・転移メカニズムの解明

1995 - Study on the invasive and metastatic potentials in the transfected human malignant cells

1994 - Study on the mechanism of invasion and metastasis of human solid tumor

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Papers (124)：

Misa Yasaka, Kazutoshi Okamura, Mayumi Shimizu, Koji Sagiyama, Tamotsu Kiyoshima, Shintaro Kawano, Masafumi Moriyama, Toru Chikui. Image findings and pathological findings of lymphoepithelial cysts with hyper internal echo-a comparison with dermoid cysts. Oral radiology. 2025
藤本龍史, 仲子勇祐, 和田裕子, 藤井慎介, 森山雅文, 川野真太郎, 清島保. 口腔病理診断が先行した腎由来口腔転移性悪性腫瘍の1例と口腔転移性悪性腫瘍の文献的比較検討. Journal of Oral Biosciences Supplement. 2024. 2024. [P3-65]
古賀理紗子, 前原隆, 上加世田泰久, 坂本泰基, 服部多市, 田中翔一, 白石由梨香, 藤井慎介, 清島保, 川野真太郎. 前舌腺由来と考えられた腺様嚢胞癌の術後7年に対側の頸部リンパ節転移を認めた1例. 日本口腔科学会雑誌. 2024. 73. 2. 206-207
Yusuke Nakako, Kana Hasegawa, Shinsuke Fujii, Yukiko Kami, Taiki Sakamoto, Mizuki Sakamoto, Masafumi Moriyama, Kari J Kurppa, Kristiina Heikinheimo, Kazunori Yoshiura, et al. Wnt/β-catenin-YAP axis in the pathogenesis of primary intraosseous carcinoma NOS, deriving from odontogenic keratocyst. Pathology, research and practice. 2024. 260. 155420-155420
Ryoko Nagano, Yusuke Nakako, Shinsuke Fujii, Shintaro Kawano, Hidefumi Maeda, Tamotsu Kiyoshima. The IL-1β-p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF-β signalling to promote cell proliferation of the lining epithelia in radicular cysts: A laboratory investigation. International endodontic journal. 2024. 57. 3. 344-354

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MISC (125)：

杉山悟郎, 山田朋弘, 鈴木あずさ, 中島梓, 安田光佑, 新甫智明, 住田知樹, 清島保, 森悦秀. 慢性GVHDに関連する口腔がんのエピジェネティック制御. 日本口腔科学会雑誌. 2019. 68. 2. 93-93
今城育美, 山田朋弘, 石井広太郎, 小倉綾乃, 清島保, 森悦秀. 当科における口腔多発腫瘍の臨床病理組織学的検討. 日本口腔科学会雑誌. 2018. 67. 2. 121-121
今城育美, 山田朋弘, 石井広太郎, 小倉綾乃, 清島保, 森悦秀. 当科における口腔多発腫瘍の臨床病理組織学的検討. 日本口腔科学会雑誌. 2018. 67. 2. 121-121
長野公喜, 山田朋弘, 秋本直柔, 上妻亜也子, 石井広太郎, 熊丸渉, 清島保, 森悦秀. HIV陰性患者の口腔内外に生じた形質芽細胞性リンパ腫(plasmablastic lympoma)の1例. 日本口腔科学会雑誌. 2017. 66. 2. 104-104
望月敬太, 松村香織, 大部一成, 森山雅文, 新井伸作, 三上友里恵, 清島保, 中村誠司. 顎関節に生じた色素性絨毛結節性滑膜炎の1例. 日本口腔科学会雑誌. 2017. 66. 2. 199-199

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Education (4)：

- 1994 Kyushu University
- 1994 Kyushu University Graduate School, Division of Dental Research
- 1990 Kyushu University School of Dentistry
- 1990 Kyushu University Faculty of Dentistry

Professional career (1)：

D.D.S., Ph.D. (Kyushu University)

Work history (10)：

2014/04 - 現在 Kyushu University Faculty of Dental Science
2012/10 - 2014/03 Kyushu University Faculty of Dental Science
2010/10 - 2012/09 - 九州大学大学院歯学研究院講師
2007 - - 九州大学大学院歯学研究院助教
1994 - 2000 Kyushu University School of Dentistry

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Association Membership(s) (13)：

日本顎関節学会 , 日本口腔腫瘍学会 , 歯科基礎医学会 , 日本口腔外科学会 , THE JAPANESE SOCIETY OF ORAL PATHOLOGY , 日本癌学会 , 日本病理学会 , The Japanese Society for the Temporomandibular joint , The Japanese Association for Oral Biology , The Japanese Society for Oral and Maxillofacial Surgeon , The Japanese Society for Oral Pathology , The Japanese Cancer Association , The Japanese Society of Pathology

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