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J-GLOBAL ID：200901004127052895 Update date: Mar. 17, 2025

Uchiyama Susumu

ウチヤマススム | Uchiyama Susumu

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Affiliation and department：
Job title： Professor
Other affiliations (1)：

National Institutes of Natural Sciences

Homepage URL (1)： https://macromolecularbiotechnology.com

Research field (4)： Pharmaceuticals - analytical and physicochemistry , Biophysics , Structural biochemistry , Biochemistry

Research keywords (4)：遺伝子治療用ベクターの分析、品質管理、製剤 , バイオ医薬品の分析、品質管理と製剤 , 蛋白質溶液論 , Biophysical Chemistry of biological macromolecules

Research theme for competitive and other funds (20)：

2024 - 2027 Development of a Novel ALS Therapeutic Strategy Targeting Primary Sensory Neurons
2017 - 2022 次世代医薬品の効率的実用化推進のための品質評価技術基盤の開発
2018 - 2020 蛍光超遠心分析法による分子夾雑環境中での定量的相互作用解析
2017 - 2020 Physico-chemical and mathematical analyses of immune related signal induced by antibody aggregates
2016 - 2018 超分子質量分析による蛋白質複合体の離合集散過程の解明

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Papers (343)：

Rio Okada, Kosei Shibata, Risa Shibuya, Tetsuo Torisu, Susumu Uchiyama. Hierarchical clustering of therapeutic proteins based on agitation-induced aggregation propensity and its relation to physicochemical parameters. European Journal of Pharmaceutical Sciences. 2025
Tetsuo Torisu, Ayuko Maeda, Shuhei Ito, Susumu Uchiyama. Protein aggregation in the frozen state induced by dropping stress. European Journal of Pharmaceutical Sciences. 2025
Shinji Kizuki, Zekun Wang, Satoru Yamauchi, Tetsuo Torisu, Susumu Uchiyama. Impact of Weak Vibration Generated by a Refrigerator on Protein Aggregation. The AAPS Journal. 2025
Yuji Kashiwakura, Yuto Nakajima, Kio Horinaka, Tiago Jose da Silva Lopes, Yuma Furuta, Yuki Yamaguchi, Nemekhbayar Baatartsogt, Morisada Hayakawa, Yuko Katakai, Susumu Uchiyama, et al. Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy. 2024
Rie Takino, Yuki Yamaguchi, Takahiro Maruno, Ekaputra Ramadhani, Misaki Furukawa, Tetsuo Torisu, Susumu Uchiyama. Physicochemical and biological impacts of light stress on adeno-associated virus serotype 6. Molecular Therapy - Methods & Clinical Development. 2024

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MISC (238)：

Mizuguchi Junya, Torisu Tetsuo, Uchiyama Susumu. Quality and Physical Properties of Food Proteins. Foods & Food Ingredients Journal of Japan. 2023. 228. 2. 130-136
HARAZONO Akira, SHIBATA Hiroko, KIYOSHI Masato, TAKESHITA Rie, SHIMBO Kazutaka, MANNEN Teruhisa, TAKASUGI Tomohiro, HAYASHI Yu, AKIMARU Michiko, SAITO Shuntaro, et al. Interlaboratory Evaluation of the Analytical Performance of Size Exclusion Chromatography for Small Aggregates in Biopharmaceuticals and Considerations on Development of Analytical Procedures. Pharmaceutical and Medical Device Regulatory Science. 2022. 53. 6. 514-533
Yamaguchi Yuki, Uchiyama Susumu. Evaluation technique for the physical properties of antibody drugs. Drug Delivery System. 2021. 36. 5. 336-341
内山進, 馬場健史, 松田史生. 特集によせて. 生物工学会誌. 2021. 99. 6. 282-283
Maruno Takahiro, Uchiyama Susumu. Analyses of Isothermal Titration Calorimetry Data Using Program SEDPHAT. Netsu Sokutei. 2020. 47. 1. 14-18

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Patents (4)：

タンパク質溶液の調製方法、当該タンパク質溶液を利用したモノクローナル抗体の作製方法及び当該モノクローナル抗体
分子間相互作用を構造に基づき判定するための支援システム、福井希一、伊藤良一、内山進
新規な生物活性評価方法
改善された保存安定性を有するタンパク質含有液体製剤

Books (7)：

バイオ医薬 : 基礎から開発まで
東京化学同人 2020 ISBN:9784807909810
ビジュアルバイオテクノロジー
化学同人 2017 ISBN:9784759819205
Analytical Ultracentrifugation, Instrumentation, Software, and Applications,
Springer 2016 ISBN:9784431559832
超遠心分析による蛋白質凝集体の評価
シーエムシー出版書籍 2015 ISBN:9784781310640
抗体の安定性の向上
シーエムシー出版 2012 ISBN:9784781306735

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Works (4)：

染色体の機能と構造に関する総合研究
2003 -
コラーゲンモデルペプチドの熱安定性に関する研究
1996 - 2001
好熱性水素細菌のシトクロームの安定性に関する研究
2000 -
IgG-Fcとそのレセプターとの相互作用に関する研究
1999 -

Education (3)：

- 1999 Osaka University
- 1996 Osaka University
- 1994 Nagoya University School of Science Department of Chemistry

Professional career (1)：

Ph. D. (Osaka University)

Work history (7)：

2018/04 - 現在 National Institutes of Natural Sciences ExCELLS
2017 - 現在 Osaka University
2020/04 - 2022/03 Kyoto University
2014/04 - 2018/03 National Institutes of Natural Sciences Okazaki Research Facilities Okazaki Institute for Integrative Bioscience
2012/02 - 2017/11 Osaka University Graduate School of Engineering

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Committee career (4)：

2018/01 - 現在日本動物細胞工学会幹事
2016/06 - 現在日本蛋白質科学会若手育成、監事、渉外、庶務
- 現在 Editorial Associate Board
2022/06 - 2024/05 日本蛋白質科学会副会長

Awards (2)：

2008/12 - 日本染色体学会染色体学会賞
2008/06 - 日本蛋白質科学会若手奨励賞

Association Membership(s) (8)：

日本抗体学会 , 日本遺伝子細胞治療学会 , American Society for Cell and Gene Therapy , 日本動物細胞工学会 , 分子生物学会 , 日本生物物理学会 , 日本蛋白質科学会 , 日本生物工学会

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