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J-GLOBAL ID：200901004162096650 Update date: Feb. 12, 2025

Junji Kato

カトウジュンジ | Junji Kato

Affiliation and department：
Job title： Professor

Research field (1)： Tumor diagnostics and therapeutics

Research keywords (1)：臨床腫瘍学肝臓病学血液病学

Research theme for competitive and other funds (64)：

2022 - 2025 Development a novel immnunotherapy for hepatocellular carcinoma targeted by BRG1
2022 - 2025 AYA世代難治性軟部肉腫に対する免疫原性細胞死を利用した新規抗がん治療法の開発
2021 - 2024 酸化的DNA傷害修復酵素欠損マウス由来肝腫瘍オルガノイドを用いた新規治療法の探索
2021 - 2024 Novel strategies for the treatment of solid tumors with CAR and CIML NK cells
2020 - 2024 TLR10の多様性に注目した胃がん発がん機構の解析

2020 - 2023 miRNAによる食道扁平上皮癌の化学放射線療法感受性予測システムの確立

2020 - 2023 膵臓癌に対する抗がん剤の腫瘍指向性を持つ新規DDSの開発

2019 - 2022 Development a novel therapy for hepatocellular carcinoma by targeting STEAP1

2019 - 2022 Development of a new targeted anticancer treatment for Adolescent and Young Adult refractory soft tissue sarcoma

2018 - 2021 Development of novel treatment for liver cancer with class-selective HDAC inhibitors

2017 - 2020 Analysis of 5-FU resistance in colon cancer using BH3 profiling

2017 - 2020 Development of a new treatment for colorectal cancer using the glucose metabolism characteristics.

2016 - 2019 selective HDAC class IIa inhibition against myeloma

2016 - 2019 HDAC inhibition against pancreatic cancer

2016 - 2019 Reactive oxygen species play roles in multiple myeloma pathogenesis

2016 - 2018 Development of novel cancer diagnostic method by detection of sugar chain in urine using glycomics analysis

2015 - 2018 Oxidative stress in hepatocarcinogenesis from NASH

2015 - 2018 Development of highly sensitive diagnostic method of gastric cancer using Liquid biopsy and Digital PCR

2014 - 2017 Prediction of drug sensitivity to gastric cancer using BH3 profiling

2015 - 2016 FUTを標的とした進行大腸癌に対する抗EMT療法の開発

2014 - 2016 Development of a novel pancreatic cancer rapid diagnostic method by the fucosyltransferases mRNA detection in peripheral blood

2013 - 2016 Identifing novel therapeutic target molecules in multiple myeloma using BCL9-ChIPSeq

2012 - 2015 Establishment of iron chelation therapy to inhibit the development of MDS

2012 - 2015 Development of the lymphocyte in vitro amplification method using HHIP KO stromal cells.

2012 - 2015 Cell targeting therapy for acute myeloid leukemia

2012 - 2015 Proteomic analysis using fluid from IPMN

2012 - 2015 Analysis of relation between oxidative DNA repair genes,MUTYH and hepatocarcinogenesis

2012 - 2015 A novel approach in the treatment of metastatic gastric cancer: targeting the STn synthase

2012 - 2013 A novel ultrasound imaging for pancreatic cancer using tumor directed-contrast media

2010 - 2012 Development of mTOR-targeted novel therapy inducing autophagy for B-cell lymphoma

2010 - 2012 大腸癌特異的な転移制御分子を標的とした新しいミサイル療法の開発

2009 - 2011 Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach

2008 - 2010 Analysis of iron regulating factors in chronic hepatitis C

2008 - 2010 Antifibrotic therapy utilizing VA-liposome-siRNAHSP47

2007 - 2008 Cell adhesion-mediated drug resistance of myeloma cells via Wnt/Rho signaling pathway

2007 - 2008 非アルコール性脂肪性肝炎発症に関わる鉄代謝異常の分子機構解析と治療法の開発

2007 - 2008 Analyze of DNA repair gene in carcinogenesis from chronic hepatitis C

2006 - 2007 TGF-βシグナルにお1るプロテインボスフターゼ2Aの癌抑制潰伝子としての意義

2005 - 2006 Ex vivo expansion of human cord blood Lin-CD34-cells using indian hedgehog stromal cells

2005 - 2006 Treatment of hepatic fibrosis in rat treated with DMN by siRNA/HSP47 encapsulated in vitamin A conjugating liposome

2005 - 2006 A role of mutated H-ferritin gene in famial gastric cancer -Analysis of mechanism using mutated H-ferritin transgenic mouse-

2005 - 2006 ANALYSYS OF GENES INVOLVED IN OXIDATIVE DNA DAMAGE IN PATIENTS WITH HEPATITIS C

2005 - 2005 慢性炎症および鉄過剰で誘導される肝発がん機構の解明とその防御

2004 - 2004 A49T変異H-フェリチントランスジェニックマウスを用いた発がん機構の解析

2002 - 2003 HCV導入肝細胞を用いたラジカル誘導性DNA傷害機構の解明とそれに基づく治療戦略

2002 - 2003 Analysis of mechanisms for resistance against TRAIL induced apoptosis in gastrointestinal cancer and development of new strategy for cancer therapy using TRAIL

2002 - 2003 Chemoprevention of colorectal cancer targeting mutated K-ras in ACF

2002 - 2002 p53を介したHDAC阻害剤によるアポトーシス誘導の機序の解明と癌治療への展開

2002 - 2002 11番染色体(11q13)上のフェリチンH鎖遺伝子変異を伴う癌多発家系の解析

2001 - 2002 Analysis of E-cadherin-Dependent Contact Inhibition in Gastric Cancer Cell Line

2001 - 2002 Development of gene therapy for advanced gastrointestinal cancer utilizing novel mutant p53 gene with effective nuclear translocation

2000 - 2000 三価金属イオン過剰により誘導されるフリーラジカルを介した細胞癌化機構の解明

1999 - 2000 Antiangiogenesis gene therapy for advanced hepatocellular carcinoma by transferrin-DNA conjugate.

1999 - 2000 Modulation of gene expression of transforming growth factor-α by ethanol in ethano-exposed hepatocytes

1997 - 1998 Contribution of transforming growth factor-a to thr development of hepatic fibrosis in alcoholic liver diseases

1995 - 1996 Analysis of beta-catenin gene in gastric cancer cells

1994 - 1995 Analysis of gene abnormalities in newly found rats with congenital defect of alcohol metabolism.

1994 - 1994 新たな肝特異機能検査としての血中アシアロ糖蛋白受容体測定系の開発:新しい肝予備能のマーカーとして

1993 - 1993 ヒト肝癌細胞由来血管新生物質の同定と分析

1991 - 1993 長期アルコール摂取の中止による肝癌発症促進機構とその予防

造血細胞分化過程における遺伝子翻訳調節

ウイルス肝炎における肝発癌機序

アルコール性肝障害の病態解析

発癌に関わる細胞内シグナル伝達機構の解析

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Papers (369)：

Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Riku Hasebe, Naoki Onoyama, Naotaka Hayasaka, Teppei Matsuno, Kazuhiko Koike, Yoshiro Gotoh, Kohji Ihara, et al. Efficacy of eribulin monotherapy for bone marrow carcinomatosis of breast cancer in a patient with Werner syndrome. Geriatrics & gerontology international. 2025
Akihito Fujimi, Yasuhiro Nagamachi, Naofumi Yamauchi, Naoki Onoyama, Naotaka Hayasaka, Teppei Matsuno, Kazuhiko Koike, Yoshiro Goto, Kohji Ihara, Junji Kato, et al. High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R. Journal of Clinical and Experimental Hematopathology. 2024
佐藤昌則, 大沼啓之, 早坂尚貴, 濱口孝太, 村瀬和幸, 高田弘一, 宮西浩嗣, 加藤淳二, 染谷正則, 坂田耕一. Stage IVa進行食道癌におけるDocetaxel/CDGP/5-FU・放射線同時併用療法(DNF-R)の予後解析. 北海道医学雑誌. 2023. 98. 2. 139-139
松村丈児, 吉田真誠, 石川和真, 久保智洋, 宮西浩嗣, 加藤淳二, 今村将史, 木村康利, 柾木喜晴, 池田裕貴, et al. 膵癌切除例における長期無再発術前予測因子の検討. 日本消化器病学会雑誌. 2023. 120. 臨増大会. A843-A843
齊藤聖也, 吉田真誠, 村松丈児, 石川和真, 柾木喜晴, 木村康利, 今村将史, 久保智洋, 村瀬和幸, 大沼啓之, et al. 術前補助療法施行後の切除可能膵癌における術後早期再発予測因子の解析. 膵臓. 2023. 38. 3. A446-A446

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MISC (272)：

田中信悟, 大場騰, 阿部記代士, 田本悠佳, 安井謙司, 大久保亜友美, 小林千紘, 齋藤和, 淺沼康一, 宮西浩嗣, et al. 【超音波ルーチン検査の実際-With SMI、そしてWith ATIの時代-】(第二部)With ATI Attenuation Imagingから始まる脂肪肝診療当院検査部での取り組みについて. 映像情報Medical. 2022. 54. 5. 45-49
大沼啓之, 小野山直輝, 濱口孝太, 早坂尚貴, 佐藤昌則, 村瀬和幸, 高田弘一, 宮西浩嗣, 村上武志, 伊東竜哉, et al. 食道癌診断と治療のup to date 食道腺癌を含めて切除可能進行食道癌に対する三剤併用療法ベースの化学放射線療法は手術療法を代替できるか?:傾向スコアマッチング分析. 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集. 2021. 128回・122回. 35-35
大沼啓之, 小野山直輝, 濱口孝太, 早坂尚貴, 佐藤昌則, 村瀬和幸, 高田弘一, 宮西浩嗣, 伊東竜哉, 信岡隆幸, et al. 切除可能進行食道癌に対する三剤併用療法ベースの化学放射線療法は手術療法を代替できるか? 傾向スコアマッチング分析. 日本消化器病学会北海道支部例会プログラム・抄録集. 2020. 126回. 50-50
Junji Kato, Koji Miyanishi. Iron and liver disease. Sapporo Medical journal. 2019. 88. 1-6. 7-12
松野鉄平, 村瀬和幸, 高田弘一, 河野豊, 平川昌宏, 宮西浩嗣, 小船雅義, 加藤淳二. 低用量IL2はBCL2の発現を誘導することでCD4制御性T細胞のアポトーシスを抑制する(Low-close interleukin-2 induces BCL2 expression and resistance to apoptosis in CD4 regulatory T Cells). 札幌医学雑誌. 2018. 87. 1-6. 49-61

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Professional career (1)：

Doctor of Medicine

Awards (1)：

2001 - 浜名湖シンポジウム最優秀賞

Association Membership(s) (24)：

日本アルコール・薬物医学会 , 米国臨床腫瘍学会 , 日本消化器内視鏡学会 , 日本臨床血液学会 , 日本癌治療学会 , 米国血液学会 , 米国癌学会 , 日本血液学会 , 日本癌学会 , 日本消化器病学会 , 日本肝臓学会 , 日本内科学会 , Japanese Medical Society of Alcohol & Drug Studies , American Society of Clinical Oncology , Japanese Association for Gastroenterological Endoscopy , Japanese Society of Clinical Hematology , Japan Society of clinical Oncology , American Society of Hematology , American Association for Cancer Research , Japanese Society of Hematology , Japanese Cancer Association , Japanese Society of Gastroenterology , Japan Society of Hepatology , Japanese Society of Internal Medicine

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