J-GLOBAL ID:200901005039350220   Update date: Oct. 24, 2021

Ihara Makoto

イハラ マコト | Ihara Makoto
Affiliation and department:
Job title: 准教授
Homepage URL  (1): http://www.nara.kindai.ac.jp/laboratory/seigyo-lab/index.html
Research field  (5): Bioorganic chemistry ,  Functional biochemistry ,  Structural biochemistry ,  Molecular biochemistry ,  Biological, health, and medical informatics
Research keywords  (4): Bioorganic chemistry ,  Pesticide science ,  構造生理学 ,  Structural Biology
Research theme for competitive and other funds  (2):
  • 2016 - 2018 Elucidation of the molecular determinants of neonicotinoid toxicity
  • 2013 - 2016 Elucidation of molecular mechanism of pyrethrin biosynthesis by a GDSL lipase and its application to creation of insect resistant plants
Papers (58):
  • Qiang Wang, Peng Xu, Felipe Andreazza, Yahui Liu, Yoshiko Nomura, Phil Duran, Lan Jiang, Mengli Chen, Genki Takamatsu, Makoto Ihara, et al. Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster. PLoS genetics. 2021. 17. 7. e1009677
  • Feng Liu, Qiang Wang, Peng Xu, Felipe Andreazza, Wilson R Valbon, Elizabeth Bandason, Mengli Chen, Ru Yan, Bo Feng, Leticia B Smith, et al. A dual-target molecular mechanism of pyrethrum repellency against mosquitoes. Nature communications. 2021. 12. 1. 2553-2553
  • Makoto Ihara, Shogo Furutani, Sho Shigetou, Shota Shimada, Kunihiro Niki, Yuma Komori, Masaki Kamiya, Wataru Koizumi, Leo Magara, Mai Hikida, et al. Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions. Proceedings of the National Academy of Sciences of the United States of America. 2020. 117. 28. 16283-16291
  • Sho Shigetou, Shota Shimada, Ihara Makoto, Kazuhiko Matsuda. Modulation by neonicotinoids of honeybee α1/chicken β2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Pesticide biochemistry and physiology. 2020. 166. 104545-104545
  • Shota Shimada, Masaki Kamiya, Sho Shigetou, Kakeru Tomiyama, Yuma Komori, Leo Magara, Makoto Ihara, Kazuhiko Matsuda. The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests. Scientific reports. 2020. 10. 1. 7529-7529
MISC (12):
Lectures and oral presentations  (4):
  • Actions of clothianidin and related neonicotinoids on recombinant and native nicotinic acetylcholine receptors.
    (XXII International Congress of Entomology, Brisbane, Australia 2004)
  • Structure activity relationship of clothianinidin and its related compounds
    (The third Pan-Pacific Conference on Pesticide Science, Hawaii, USA. 2003)
  • Variations in agonist and antagonist profiles for neonicotinoids on recombinant nicotinic acetylcholine receptors expressed in Xenopus oocytes
    (10th IUPAC International Congress on the Chemistry of Crop Protection, Basel, Switzerland. 2002)
  • Actions of clothianidin and related compounds on recombinant nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes
    (Neurotox 2003, Nottingham, UK.)
Education (3):
  • - 2005 Kindai University Major in Advanced life Science
  • - 2002 Kindai University Major in Advanced life Science
  • - 2000 Kindai University
Professional career (1):
  • PhD (Kinki University)
Work history (6):
  • 2018/04 - 現在 Kindai University Fuculty of agriculture Associate professor
  • 2013/04 - 2018/03 Kinki University Faculty of Agriculture Lecturer
  • 2012/12 - 2018/03 RIKEN SPring-8 Center Visiting Scientist
  • 2012/12 - 2013/03 Okayama University, Graduate school of medicine, dentistry and pharmaceutical sciences Assistant Professor
  • 2006/10 - 2012/11 RIKEN
Show all
Awards (4):
  • 2018/03 - 日本農芸化学会 農芸化学奨励賞
  • 2008 - 日本農学進歩賞
  • 2007 - 望月喜多司記念賞 奨励賞
  • 2007 - 日本農薬学会 奨励賞
Association Membership(s) (3):
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