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J-GLOBAL ID：200901008104037444 Update date: Feb. 27, 2025

Nishi Akinori

ニシアキノリ | Nishi Akinori

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Affiliation and department：
Homepage URL (1)： http://www.med.kurume-u.ac.jp/med/pharm/index.html

Research field (2)： Neuroscience - general , Fetal medicine/Pediatrics

Research keywords (14)：抗精神病薬 , 抗うつ薬 , 海馬歯状回 , ドパミンD1受容体 , うつ病 , 統合失調症 , ドパミン , DARPP-32 , 線条体 , リン酸化 , 細胞内情報伝達 , モノアミン , 神経伝達物質 , 薬物療法

Research theme for competitive and other funds (37)：

2023 - 2026 アセチルコリン/ドパミン神経回路を標的としたうつ病の新規治療法の探索
2023 - 2026 抗うつ薬作用増強に必要なドパミン・ノルアドレナリン神経回路機構の解明
2023 - 2026 Development of treatments for post traumatic stress disorder related to surgery and intensive care.
2022 - 2025 統合失調症のドーパミン仮説を実現するモデルマウスの神経学的病態機構の解明
2022 - 2025 炎症性疾患によるうつ病発症機序の解明:脳内ドパミンシグナルに着目して

2022 - 2025 Elucidating the mechanisms by which female mice identify attractive male mice.

2022 - 2025 Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling

2019 - 2022 Involvement of dopamine and noradrenaline signaling mechanisms in depression and schizophrenia.

2019 - 2022 Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system

2018 - 2021 Investigation of the interaction between dopamine and noradrenaline signaling in the hippocampus to develop novel treatment of depression

2018 - 2021 Novel approaches for treatment of addiction after social defeat stress

2016 - 2020 Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signal

2016 - 2019 Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders

2016 - 2019 Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders

2015 - 2018 Does oxdative stress reaction in nucleus accumbes exacerbate cocaine addiction after social defeat stress?

2016 - 2018 治療抵抗性統合失調症の診断法及び治療法の開発

2014 - 2017 Role of chondroitin sulfate-E in the modulation of neuronal morphology

2016 - 2017 ドパミン神経系を標的とした精神神経疾患治療薬の創薬基盤研究

2012 - 2015 Functional role of the N-terminal domain of DFosB in response to stress and drugs of abuse.

2012 - 2012 ptimization of FIB/SEM techniques ? the novel ultrastructureeanalysis by combination of serial thin ablation and block surface material contrastobservation - for biomedical mesoscale three dimentional structural analysis.

2007 - 2012 精神疾患モデルマウスの脳のシグナル伝達の生化学的解析

2010 - 2011 遺伝子発現を制御するドーパミンシグナル:DARPP-32を介する調節機構

2009 - 2010 ドーパミンシグナルの多様性を探る:神経サブタイプ個別解析

2008 - 2009 神経再生療法開発のための基礎的研究

2006 - 2007 線条体領域ドーパミン情報伝達マップ:病態モデルへの展開

2004 - 2005 Elucidating the structure and function of chondrotin sulfate proteoglycan in differentitation, development and regeneration of dopaminergic neurons

2004 - 2005 線条体領域ドーパミン情報伝達マップ

2003 - 2004 Role of GABA_B receptors in dopamine/DARPP-32 signaling

2002 - 2004 神経発達を促進する分子機構の研究

2001 - 2004 Neurochemical studies on pathophysiology and treatment of attention deficit hyperactivity disorder

2002 - 2003 線条体ドーパミン情報伝達機構の生後発達:注意欠陥・多動性障害病態解明へのアプローチ

2002 - 2003 線条体神経におけるドーパミン抑制性入力とグルタミン酸興奮性入力の統合

2001 - 2002 ドーパミン情報伝達とシグナル統合細胞間分子回路

2000 - 2001 ドーパミン情報伝達系、特にドーパミンD1シグナル増幅系分子機構の解析

1999 - 2000 線条体神経細胞におけるドーパミン情報伝達系、特にDARPP-32リン酸化を介する分子機構の解析

1999 - 2000 線条体神経細胞でのドーパミン情報伝達系、特にD1/D2レセプター相互作用の解析

1998 - 1999 線条体神経細胞でのレセプター刺激/蛋白リン酸化を介する細胞内シグナリングの解析

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Papers (136)：

西昭徳. 炎症性腸疾患に伴う抑うつ・不安 ~炎症抑制によるアプローチ~. Depression Strategy. 2024. 14. 3. 13-15
Ryusuke Sin, Naoki Sotogaku, Yoshinori N. Ohnishi, Takahide Shuto, Mahomi Kuroiwa, Yukie Kawahara, Keita Sugiyama, Yuki Murakami, Masaaki Kanai, Hiroshi Funakoshi, et al. Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments. Brain, Behavior, and Immunity. 2023
Mahomi Kuroiwa, Takahide Shuto, Taku Nagai, Mutsuki Amano, Kozo Kaibuchi, Angus C Nairn, Akinori Nishi. DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum. Neurochemistry international. 2023. 162. 105438-105438
Hideo Hagihara, Hirotaka Shoji, Mahomi Kuroiwa, Isabella A Graef, Gerald R Crabtree, Akinori Nishi, Tsuyoshi Miyakawa. Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice. Molecular brain. 2022. 15. 1. 94-94
Minoru Hatayama, Kei-Ichi Katayama, Yukie Kawahara, Hayato Matsunaga, Noriko Takashima, Yoshimi Iwayama, Yoshifumi Matsumoto, Akinori Nishi, Takeo Yoshikawa, Jun Aruga. SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex. Communications biology. 2022. 5. 1. 935-935

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MISC (100)：

弓削康太郎, 高橋知之, 弓削康太郎, 高橋知之, 河原幸江, 坂井勇介, 佐藤貴弘, 児島将康, 西昭徳, 松石豊次郎, et al. レット症候群モデルマウスにおける睡眠・覚醒病態とオレキシンシグナル伝達の異常. 日本脳科学会プログラム・講演抄録集. 2022. 49th
OHNISHI Yoshinori, KAWAHARA Yukie, KISHI Yuki, OHNISHI Yoko, NISHI Akinori. What methods are physiologically or pharmacologically effective for attracting female mice?. 日本薬理学会年会要旨集(Web). 2022. 95th
大西克典, 河原幸恵, 大西陽子, 西昭徳. Is male mouse attractiveness inherited?. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
大西克典, 河原幸江, 大西陽子, 西昭徳. 魅力的なオスマウスの剃毛はメスマウスを惹きつける力を失わせか?. 日本薬理学雑誌. 2021. 156. Supplement
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳. Differential role of dopamine in the PFC and NAc in cocaine-associated reward memory and behavior. 日本薬理学雑誌. 2021. 156. Supplement

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Patents (3)：

IL-1ß阻害薬
うつ病治療のための併用剤
ドーパミンシグナル伝達の抑制剤

Books (5)：

薬の基本とはたらきがわかる薬理学
羊土社 2023
エース薬理学
南山堂 2020
ベッドサイドの薬理学
丸善出版 2018
リハ研究の進め方・まとめ方
医歯薬出版 2017
The role of phosphodiesterases in disorders of motivated behavior, in Cyclic-nucleotide phosphodiesterases in the central nervous system from biology to drug discovery
Wiley & Sons, Inc. 2014

Education (2)：

1989 - 1993 Karolinska Institutet
1979 - 1985 Miyazaki Medical College

Professional career (2)：

博士(医学) (久留米大学)
Ph.D. (カロリンスカ研究所)

Work history (8)：

2024/04 - 現在 Kurume University
2015 - 現在 Kurume University Kurume University
2006 - 現在 Kurume University School of Medicine
1997 - 2020 ロックフェラー大学客員研究員
2004 - 2006 Kurume University School of Medicine

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Association Membership(s) (5)：

JAPAN BRAIN SCIENCE SOCIETY , THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS , JAPAN PEDIATRIC SOCIETY , THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY , THE JAPANESE PHARMACOLOGICAL SOCIETY

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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