Rchr
J-GLOBAL ID:200901008131100379
Update date: Dec. 10, 2024
Ikehara Yuzuru
イケハラ ユズル | Ikehara Yuzuru
Affiliation and department:
Job title:
Professor
Research field (6):
Human pathology
, Chemical reaction and process system engineering
, Nanobioscience
, Tumor diagnostics and therapeutics
, Pathobiochemistry
, Medical systems
Research keywords (5):
Carcinogenesis
, 走査電子顕微鏡・EDXイメージング
, NIR imaging
, Plasma Medicine
, Glycobiology
Research theme for competitive and other funds (34):
- 2024 - 2027 がん関連stiff-collagen制御機構の解明を基盤とした新規がん免疫強化治療戦略の開拓
- 2023 - 2027 Elucidation of signaling modules mediated by glycosaminoglycans in tumor stroma formation
- 2023 - 2027 リンパ管内皮細胞の再生と誘導による革新的皮膚抗老化治療の開発
- 2020 - 2026 ウイルス-人体相互作用ネットワークの理解と操作
- 2019 - 2024 Elucidation of pathogenic immunological memory to understand the pathogenesis of intractable inflammatory diseases
- 2018 - 2023 気道組織における病的リモデリング(線維化)機構の解明と病態制御治療戦略の基盤構築
- 2019 - 2022 Elucidation of the differentiation mechanism of cancer-related fibroblasts using genetically engineered mouse models that develop pancreatic ductal adenocarcinoma
- 2019 - 2022 1450nm計測イメージングによる分子病理解析システムの開発研究
- 2020 - 2022 新型コロナウイルス感染症で血管炎を誘導する新たな病的免疫細胞集団の同定と病態形成機構の解明
- 2017 - 2018 Plasma Science Innovation
- 2016 - 2018 The impact of visceral obesity-induced insulin resistance and chronic inflammation on breast cancer chemotherapy for Japanese patients
- 2015 - 2018 Elucidation of molecular mechanism of pancreatic cancer showing catastrophic progression
- 2012 - 2017 Plasma Medical Science Innovation
- 2012 - 2017 Elucidation of interactive mechanism on wound healing process after low temperature plasma treatment
- 2013 - 2016 Study on innovative nano particle drag for neutron capture therapy
- 2012 - 2015 Determination of cancer stem cells and evaluation for cancer immunotherapy against cancer stem cells
- 2011 - 2014 Clinical test system utilizing near infrared fluorescence of nanotubes
- 2006 - 2011 病原性原虫によるTh1免疫回避機構の解読と糖鎖被覆リポソームの適応開拓
- 2009 - 2011 Analysis of immunosuppression mechanism by sialic acids on cancer cells, and a feasible study to control immune reaction using sialylated carbohydrates.
- 2006 - 2010 病原性原虫によるTh1免疫回避機構の解読と糖鎖被覆リポソームの適応開拓
- 2008 - 2009 微小転移を標的とする新しい胃癌の再発予防戦略
- 2005 - 2009 ヘリコバクター・ピロリ感染による実験胃がんとその発症因子の解析
- 2007 - 2008 Suppression mechanism for anti-tumor immune response through sialyl In antigen
- 2006 - 2007 糖転移酵素ノックアウトマウスを用いたバベシア原虫による赤血球感染機構の解明
- 2004 - 2007 がん免疫担当細胞におけるシアル酸受容体シグレック7と9による負の制御機構の解明
- 2004 - 2006 がん免疫担当細胞におけるシアル酸受容体シグレック7と9による負の制御機構の解明
- 2003 - 2006 マクロファージの免疫応答能を活用するドラッグデリバリーシステムの構築
- 2000 - 2004 Gene alterations during stomach carciro genesis in H. pyrori infected Mongolian gerbik
- 2001 - 2002 Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter phylori-infected Mongolian Gerbils on Eradication
- 2000 - 2001 STn抗原を認識するレセプター蛋白のクローニングと胃癌の進展に及ぼす機能の解析
- 1999 - 2001 Analysis of micrometastasis formation using marker geno-tagged tumor cells and its clinical application
- 1999 - 2000 Analysis of genomic changes in the intestinal metaplastic epithelial cells of the human stomach
- Developement of drug delivery system on biological function of carbohydrates
- Elucidating the biological function of Sialyl Tn antigen on the course of cancer development
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Papers (183):
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Emiri Yamamoto, Shinsuke Akita, Sanae Ikehara, Kazuhiko Azuma, Syota Ohki, Yoshihiro Nakano, Shigehito Sakai, Hiroyuki Matsuyama, Takashi Yamaguchi, Hajime Sakakita, et al. Application and Evaluation of Plasma Generated by Asymmetric Surface Discharge on the Ceramic Surface to Hemostatic Equipment. Plasma Medicine,. 2024. 14. 3. 23-36
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Ami Aoki, Chiaki Iwamura, Masahiro Kiuchi, Kaori Tsuji, Atsushi Sasaki, Takahisa Hishiya, Rui Hirasawa, Kota Kokubo, Sachiko Kuriyama, Atsushi Onodera, et al. Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients. Journal of clinical immunology. 2024. 44. 4. 104-104
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Hayato Ota, Hirokazu Sato, Shuji Mizumoto, Ken Wakai, Kei Yoneda, Kazuo Yamamoto, Hayao Nakanishi, Jun-Ichiro Ikeda, Shinichi Sakamoto, Tomohiko Ichikawa, et al. Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer. Scientific Reports. 2023. 13. 1. 11618-11618
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Karin Murakami, Ryo Tamura, Sanae Ikehara, Hayato Ota, Tomomi Ichimiya, Naoki Matsumoto, Hisahiro Matsubara, Shoko Nishihara, Yuzuru Ikehara, Kazuo Yamamoto. Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry. Biochemical Journal. 2023. 480. 1. 41-56
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Mikiko Okano, Kiyoshi Hirahara, Masahiro Kiuchi, Miki Onoue, Chiaki Iwamura, Kota Kokubo, Takahisa Hishiya, Yuki Morimoto, Yuzuru Ikehara, Akira Murakami, et al. Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch. Immunity. 2022. 55. 12. 2352-2368
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MISC (565):
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貝塚祐太, 山本一夫, 池原早苗, 池原譲. Development of Bromine/Iodine-Labeled Benzidine Derivatives as Staining Agents for Electron Microscopy. ヨウ素. 2024. 27
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秋田 新介, 緒方 英之, 板井 菜緒, ガントゥムル・エンフトール, 辻田 恭子, 加治屋 健太朗, 三川 信之, 池原 譲. リンパ浮腫の治療戦略 リンパ管の機能と組織学的変化が治療方針に与える影響. 日本創傷治癒学会プログラム・抄録集. 2023. 53回. 63-63
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太田 隼人, 佐藤 大一, 水本 秀二, 若井 健, 米田 慧, 山本 一夫, 中西 速夫, 池田 純一郎, 坂本 信一, 市川 智彦, et al. 前立腺がんは3-O-硫酸化ヘパラン硫酸を介して去勢抵抗性を獲得する. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-652]
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松原 久裕, 村上 健太郎, 石川 仁, 山田 滋, 池田 純一郎, 池原 譲. 疾患の理解が未来医療を拓く-病理学:Devil river、Death valley、Darwin' seaを行くための羅針盤- 病理学的検討を礎とする食道癌未来医療開発. 日本病理学会会誌. 2023. 112. 1. 157-157
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村上 未樹, 池原 早苗, 東 和彦, 大木 翔太, 若井 健, 山口 高志, 山本 一夫, 鈴木 良夫, 池田 純一郎, 池原 譲. ムコール真菌の糖鎖を検出する組織学的解析方法の確立. 日本病理学会会誌. 2023. 112. 1. 351-351
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Patents (107):
Books (31):
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Clinical Immunology and Allergology To perform electron microscope analysis using spatial omics analysis.
2024
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論文図表を読む作法 : はじめて出会う実験&解析法も正しく解釈! : 生命科学・医学論文をスラスラ読むためのFigure事典
羊土社 2022 ISBN:9784758122603
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J. Plasma Fusion Res. 95(4)
2019
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IEC 60601-2-76: Medical Electrical equipment - Part 2-76: Particular requirements for the basic safety and essential performance or ionized gas coagulation equipment.
2018
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Plasma Medical Science
Academic Press, imprint of Elsevier 2018 ISBN:9780128150047
more...
Lectures and oral presentations (51):
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Minimally Invasive Hemostasis
(2024)
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Heavy Ion Therapy
(2024)
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Soft material nano-imaging technology
(2024)
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Hemostasis by plasma treatment shortens the wound healing duration by bypassing the inflammatory response and proliferation of bone marrow-derived fibroblasts.
(10TH INTERNATIONAL CONFERENCE ON PLASMA MEDICINE (ICPM10) 2024)
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Developing a conductive treatment method for pathological specimens using plasma for the diagnosis using electron microscopy.
(10th International Conference on Plasma Medicine (ICPM10) 2024)
more...
Works (1):
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糖鎖認識にもとずく免疫応答を活用するドラッグデリバリーシステムの構築とその技術応用の開拓
2003 - 現在
Education (2):
- Shiga University of Medical Science Undergraduate School of Medicine
- Shiga University of Medical Science Undergraduate School of Medicine
Professional career (1):
- MD. (Shiga University of Medical Science)
Work history (10):
- 2015/07 - 現在 Chiba University Department of Pathology, Graduate School of Medicine
- 2015/07 - 2024/03 National Institute of Advanced Industrial Science and Technology
- 2015/07 - 2024/03 National Institute of Advanced Industrial Science and Technology Cellular and Molecular Biotechnology Research Institute Senior Chief Researcher
- 2018/03 - 2022/03 University of Southern California Keck school of medicine Visiting Professor
- 2013 - 2015/07 産業技術総合研究所・創薬基盤研究部門/電子光技術研究部門 上級主任研究員
- 2008/03 - 2013/03 産業技術総合研究所 糖鎖医工学研究センター 研究チーム長
- 2005/04 - 2006/03 Aichi Cancer Center, Research Institute
- 2003/08 - 2005/03 Aichi Cancer Center, Research Institute
- 2001/08 - 2003/08 The Scripps Research Institute Dept. of Molecular Biology
- - 2003 1999 July-2003 Aug.愛知県がんセンター研究所 腫瘍病理学部研究員
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Committee career (6):
Awards (5):
- 2023/11 - 公益社団法人発明協会 令和5年度近畿地方発明表彰 文部科学大臣賞 新規な肝線維化検査方法(特許第5031928号)
- 2022/06 - International Society for Plasma Medicine Plasma Medicine Award
- 2015 - 産業技術総合研究所 平成26年度 産総研 理事長賞(本格研究) 「肝疾患糖鎖バイオマーカーの開発」
- 2012 - 日本病理学会 日本病理学会学術研究賞 生物機能と疾患の理解を目指した糖鎖生物学研究
- 2002 - 2002 Travel awards, American Society of Glycobiology
Association Membership(s) (7):
American Society of Glycobiology
, 日本病理学会
, 癌学会
, International Society on Plasma Medicine
, 日本分子腫瘍マーカー研究会
, THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH
, プラズマ核融合学会
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