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J-GLOBAL ID：200901008308102423 Update date: Apr. 15, 2025

SHINDO TAKAYUKI

シンドウタカユキ | SHINDO TAKAYUKI

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Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www7a.biglobe.ne.jp/~shindo/

Research field (2)： Metabolism and endocrinology , Cardiology

Research keywords (2)： Cardiovascular Research , Mice Gene Engineering

Research theme for competitive and other funds (27)：

2021 - 2024 受容体活性調節システムによる生体内恒常性制御機構の解明と創薬への展開
2020 - 2023 血管およびリンパ管の恒常性制御は、癌転移抑制法となりうるか?
2019 - 2022 Analyses of functional differentiation and interaction of RAMP1,2 and 3 applying the maternal Cas9-based multiple genome editing
2018 - 2021 Development of a novel therapy for lifestyle-related diseases and chronic organ damage by targeting the homeostatic regulation within the body
2016 - 2018 Maternal Cas9-based genome editing system as a useful tool for creating simultaneous multiple-gene modified mice

2014 - 2017 Clarification and application of a novel in vivo system which regulates interacting and homeostasis of organs

2014 - 2017 Different roles of receptor activity modifying protein subtypes: ramp2 and ramp3 in development of colitis

2014 - 2016 Multiple-gene editing system using a non-inheritable maternal Cas9 in mice

2011 - 2013 Elucidation of the crucial role of Adrenomedullin-Ramp2,Ramp3 system in mouse models of inflammation

2011 - 2012 RAMP2は、アドレノメデュリンに代わる治療標的となりうるか?

2010 - 2012 Investigation about the effect of Adrenomedullin on pulmonary function and development of emphysema of old mice

2011 - 2011 新しい血管統合機構に基づく、慢性臓器障害治療法の開発

2009 - 2011 Involvement of calcitonin gene-related peptide family in various pain states

2008 - 2010 Studies of pathophysiological role of Adrenomedullin-RAMP system using genetically modified RAMP mice

2008 - 2010 Development of new treatment modality for diabetic macular edema using knockout mice that show prominent retinal edema.

2008 - 2010 Clarification of the mechanism of metabolic and vascular regulation by RAMP and its application in metabolic disorders and vascular injuries.

2006 - 2007 Production and characterization of Adrenomedullin (-/-)<->(+/+) and RAMP2(-/-)<-> (+/+) chimeric mice

2004 - 2005 Pathophysiological role of Adrenomedullin on the etiology of bronchial asthma and pulmonary fibrosis

2003 - 2004 転写因子KLF5の心血管リモデリング制御機構の解明と治療への応用

2003 - 2004 Identification of the Receptor for ORAIP That Mediates Cardiac Response to Oxidative Stresses and Development of Treatment

2002 - 2003 KLF5ヘテロノックアウトマウスを用いた腸管障害モデルの病理学的分子生物学的解析

2002 - 2003 Roles of CGRP family peptides in the molecular mechanisms underlying bronchial asthma: the development of novel therapeutic approach

Development of novel technique for genome editing

Generation of novel genetically engineerd mice.

Regenerative medicine of blood vessel.

Pathophysiological roles of vasoactive peptides and their receptor system.

Development of new therapy using animal models of atherosclerosis, hypertension, heart failure, renal failure and liver failure.

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Papers (216)：

Takayuki Sakurai, Norio Takei, Yangxuan Wei, Marina Hayashi, Akiko Kamiyoshi, Hisaka Kawate, Satoshi Watanabe, Masahiro Sato, Takayuki Shindo. Efficient genome editing of two-cell mouse embryos via modified CRISPR/Cas electroporation. Scientific Reports. 2024. 14. 1
Tomoki Kasahara, Megumu Tanaka, Yunlu Zhao, Akiko Kamiyoshi, Takayuki Sakurai, Yuka Ichikawa-Shindo, Hisaka Kawate, Yorishige Matsuda, Yan Zhang, Qianqian Guo, et al. Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS. Peptides. 2024. 171. 171118-171118
田中愛, 桜井敬之, 神吉昭子, 新藤優佳, 河手久香, 柿原伸次, Zhao Yunlu, 松田順繁, Zhang Yan, Guo Qianqian, et al. Vascular Homeostatic Function of the AM-RAMP2 System and Its Application to the Regulation of Lymph Node Metastasis(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. OJ22-2
田中愛, 桜井敬之, 神吉昭子, 市川優佳, 河手久香, グオ・チェンチェン, リ・ペイセン, 大西菜穂, 笠原智貴, 新藤隆行. AM-RAMP2系の血管恒常性制御を介したリンパ節転移抑制作用. 日本内分泌学会雑誌. 2023. 98. 5. 1571-1571
Shinji Kakihara, Yorishige Matsuda, Kazutaka Hirabayashi, Akira Imai, Yasuhiro Iesato, Takayuki Sakurai, Akiko Kamiyoshi, Megumu Tanaka, Yuka Ichikawa-Shindo, Hisaka Kawate, et al. Role of Adrenomedullin 2/Intermedin in the Pathogenesis of Neovascular Age-Related Macular Degeneration. Laboratory investigation; a journal of technical methods and pathology. 2023. 103. 4. 100038-100038

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MISC (97)：

有賀公亮, 桜井敬之, 神吉昭子, 新藤優佳, 河手久香, 田中愛, 柿原伸次, ZHAO Yunlu, 松田順繁, 笠原智貴, et al. Elucidation of the Significance of the Adrenomedullin-RAMP System as a Novel Therapeutic Target for Sarcopenia. 日本循環器学会学術集会(Web). 2022. 86th
神吉昭子, 桜井敬之, 新藤優佳, 河手久香, 田中愛, 柿原伸次, ZHAO Yunlu, 松田順繁, 有賀公亮, 笠原智貴, et al. Pathophysiological Significance of Adrenomedullin 2 in Hepatic and Metabolic Regulation. 日本循環器学会学術集会(Web). 2022. 86th
神吉昭子, 桜井敬之, 桜井敬之, 新藤優佳, 河手久香, 田中愛, 崔南奇, WEI Yangxuan, ZHAO Yunlu, 有賀公亮, et al. Intermedin/Adrenomedullin 2 deficiency causes obesity and liver dysfunction under high-fat diet. 日本心血管内分泌代謝学会学術総会プログラム及び抄録集. 2021. 24th (Web)
神吉昭子, 神吉昭子, 桜井敬之, 桜井敬之, 新藤優佳, 河手久香, 田中愛, 崔南奇, 田中正明, WEI Yangxuan, et al. 肥満および脂肪肝におけるアドレノメデュリン2の病態生理学的意義. 日本内分泌学会雑誌. 2021. 97. 1
田中正明, 柿原伸次, 桜井敬之, 神吉昭子, 新藤優佳, 河手久香, 田中愛, 崔南奇, WEI Yangxuan, ZHAO Yunlu, et al. Adrenomedullin-RAMP2 System Ameliorates Age-Related Macular Degeneration by Suppressing Choroidal Neovascularization and Subretinal Fibrosis. 日本循環器学会学術集会(Web). 2021. 85th

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Books (15)：

Methods Mol Biol.1874
2019
Results Probl Cell Differ.63
2017
Oocytes Maternal information and functions
Springer 2017
血管生物学辞典
朝倉書店 2011
血管生物学辞典
朝倉書店 2011

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Lectures and oral presentations (197)：

Metabolic regulation by the adrenomedullin2-RAMP3 system
(第88回日本循環器学会 2024)
Protective effects of adrenomedullin 2 against heart failure by regulating the metabolism of cardiac myocytes
(第88回日本循環器学会 2024)
Vascular homeostasis by the AM-RAMP2 system promotes T cell recruitment, prevents cancer cell migration, and suppresses lymph node metastasis.
(第88回日本循環器学会 2024)
アドレノメデュリンの受容体活性調節システムを標的とした癌転移の制御
(第53回日本心脈管作動物質学会 2024)
アドレノメデュリン2は、心筋細胞のミトコンドリア機能と代謝系シグナルを制御し、心保護に働く
(第53回日本心脈管作動物質学会 2024)

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Education (2)：

1994 - 1998 The University of Tokyo Graduate School of Medicine
1985 - 1991 The University of Tokyo Faculty of Medicine

Professional career (1)：

Ph.D. in Cardiovascular Science (University of Tokyo)

Work history (2)：

2004/08/15 - Professor, Department of Cardiovascular Research, Shinshu University, School of Medicine
2002/07/01 - Assistant Professor, Department of Cardiovascular Medicine, University of Tokyo

Committee career (8)：

日本血管生物医学会評議員
日本心脈管作動物質学会理事
日本心血管内分泌代謝学会理事
日本動脈硬化学会評議員
医学部図書館長

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Awards (20)：

2023 - 松尾壽之賞
2014 - 老年病研究所ダビンチ賞
2010 - 信州大学医学部特別賞
2009 - 高峰譲吉研究奨励賞
2006 - 国際高血圧学会 JSH Award

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Association Membership(s) (17)：

日本ゲノム編集学会 , 日本サルコペニア、フレイル学会 , 日本感染症学会 , 日本褥瘡学会 , 日本アレルギー学会 , 日本動脈硬化学会 , 国際心臓研究会 , 日本超音波医学会 , 日本再生医療学会 , 日本炎症再生学会 , 日本老年医学会 , 日本脈管学会 , アメリカ心臓協会 , 日本内分泌学会 , 日本高血圧学会 , 日本循環器学会 , 日本内科学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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