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J-GLOBAL ID：200901008801888061 Update date: Apr. 02, 2025

Arai Satoshi

アライサトシ | Arai Satoshi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://sites.google.com/view/satoshiarai

Research field (3)： Analytical chemistry , Chemical biology , Nanobioscience

Research keywords (5)： Fluorescence Imaging , Thermodynamics , Material Chemistry , Genetic Engineering , Chemical Biology

Research theme for competitive and other funds (22)：

2024 - 2029 Mechanisms of cellular functional modification induced by unconventional proteins transported to mitochondria in myocyte
2023 - 2027 形状依存ビルディングブロック集積による細胞内ナノ粒子の高効率機能発現
2024 - 2027 複数シグナル分子のマルチチャネル型制御システムの創出
2024 - 2027 光熱変換色素による脂質膜動態制御と細胞機能解析・操作
2024 - 2027 Development of ultrahigh-performance quantitative L-lactate biosensor

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Papers (70)：

Yongwei Jing, Masahiko Kobayashi, Mahmoud I Shoulkamy, Meiqi Zhou, Ha Thi Vu, Hiroshi Arakawa, Hemragul Sabit, Sadahiro Iwabuchi, Cong Quang Vu, Atsuko Kasahara, Masaya Ueno, Yuko Tadokoro, Kenta Kurayoshi, Xi Chen, Yuhang Yan, Satoshi Arai, Shinichi Hashimoto, Tomoyoshi Soga, Tomoki Todo, Mitsutoshi Nakada, Atsushi Hirao. Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma. Nature Communications. 2025. 16. 1. 2876
Satoshi Arai, Kayoko Nomura, Cong Q. VU, Takeru Yamazaki. BPS2025 - FLIM biosensor platform unveils heat production at the subcellular scale in thermogenic cells. Biophysical Journal. 2025. 124. 3. 503a-503a
Satoshi Arai. Microscopic Measurement and Control of Intracellular Temperature using Functional Dyes. MEMBRANE. 2025. 50. 1. 19-26
Chongxia Zhong, Satoshi Arai, Yasushi Okada. Development of fluorescence lifetime biosensors for ATP, cAMP, citrate, and glucose using the mTurquoise2-based platform. Cell Reports Methods. 2024. 4. 11. 100902-100902
Satya Ranjan Sarker, Takeru Yamazaki, Keitaro Sou, Ichiro Takemura, Yusuke Kurita, Kayoko Nomura, Mari Ichimura, Takahito Suzuki, Ayumi Kai, Takumi Araki, et al. Harnessing Dye-induced Photothermal Confinement in Lipid Membranes: A Path to NIR-modulated Artificial Synaptic Vesicles. bioRxiv. 2024

MISC (18)：

新井敏, VU Cong Quang, 山崎健. 細胞の定常状態の定量解析を可能にするFLIM型センサープラットフォーム. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
NGUYEN Loan Thi Ngoc, VU Cong Quang, ARAI Satoshi. Investigating intracellular GTP level on cellular processes using a single uorescence-based FLIM indicator. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
VU Cong Quang, NGUYEN Loan Thi Ngoc, YAMAZAKI Takeru, ARAI Satoshi. Measuring Ca²⁺ concentrations in the cytoplasm, mitochondria, endoplasmic reticulum, and extracellular space with multi-color fluorescence lifetime biosensors. 日本分子生物学会年会プログラム・要旨集(Web). 2024. 47th
河村亜希, 河村亜希, 新井敏, VU Quang Cong, 芝口翼, 清水菜穂子, 増田和実. 骨格筋細胞におけるFLIM-Ca²⁺センサーを用いた細胞質および核のCa²⁺濃度の定量解析. 日本運動生理学会大会プログラム・抄録集. 2024. 32nd
隅田有人, 新井敏, 大宮寛久. Radical Caging Technology. 京都大学研究連携基盤持続可能社会創造ユニット研究成果報告書. 2024. 2023

Patents (4)：

Books (11)：

細胞小器官の温度測定のための蛍光温度センサー
温度ストレスによる生体応答ダイナミクス (NTS) 2023
分子交雑空間の熱力学エンジニアリング
生体分子環境の化学日本化学会 CSJカレントレビュー 2023
Summary and perspective: molecular-sized Organelle Targeted Thermometers
the New Science Co., Ltd. 2020
細胞内ATPの同時計測を可能にする3色の蛍光センサー
バイオサイエンスとインダストリー 2019
Nanosized Optical Thermometers
2018

Lectures and oral presentations (49)：

Imaging and Control of Cellular Heat with Functional Dyes
(APPW 2025:第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会 2025)
FLIM BIOSENSOR PLATFORM UNVEILS HEAT PRODUCTION AT THE SUBCELLULAR SCALE IN THERMOGENIC CELLS
(Biophysical Society Annual Meeting 2025, los angeles, Platform Talk 2025)
機能性色素による小器官温度の計測と操作
(2024)
Nanothermometry and nanoheating platforms for thermal cell engineering
(International Symposium on Exponential Biomedical DX 2024 2024)
Nanothermometry And Local Heating Of Lipid Membranes: Strategies For Manipulating Cellular Functions
(12th Singapore International Chemistry Conference in conjunction with the Angewandte Chemie Symposium 2024 2024)

Professional career (1)：

Work history (10)：

2024/07 - 現在金沢大学ナノ生命科学研究所教授
2021/04 - 現在 JST創発研究者
2019/07 - 2024/06 金沢大学ナノ生命科学研究所准教授
2017/04 - 2019/03 Waseda University Research Institute for Science and Engineering
2015/10 - 2019/03 Japan Agency for Medical Research and Development

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Awards (4)：

Association Membership(s) (3)：

THE SOCIETY OF POLYMER SCIENCE, JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE BIOPHYSICAL SOCIETY OF JAPAN

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