Research field (2)：
Bioorganic chemistry
, Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds (5)：
2021 - 2024 Optimization of SARS 3CL protease inhibitor and development of anti-COVID-19 drug
2017 - 2020 Development of novel therapeutic agents for schizophrenia based on kynurenine hypothesis
2015 - 2017 Development of novel BACE1 inhibitors based on the N-amidino nitrogen-containing ring structure
2013 - 2016 Design of non-peptide inhibitors based on structure analyses of the protease/inhibitor complex
2013 - 2015 Development of novel BACE1 inhibitors: Structure activity relationship study based on the substrate sequence
Papers (76)：
Chiyuki Awahara, Daiki Oku, Kazuya Kobayashi, Yasunao Hattori. Evaluating a Retro-Inverso Type Inhibitor of HTLV-1 Protease as a Competitive Inhibitor. Chemical & pharmaceutical bulletin. 2024. 72. 3. 309-310
Marina Omokawa, Hiroyuki Kimura, Kenji Arimitsu, Yusuke Yagi, Yasunao Hattori, Hidekazu Kawashima, Yuki Naito, Hiroyuki Yasui. Synthesis and Biological Evaluation of a Novel Sugar-Conjugated Platinum(II) Complex Having a Tumor-Targeting Effect. ACS Omega. 2023
Yuto Kondo, Hiroyuki Kimura, Minon Sasaki, Sumina Koike, Yusuke Yagi, Yasunao Hattori, Hidekazu Kawashima, Hiroyuki Yasui. Effect of Water on Direct Radioiodination of Small Molecules/Peptides Using Copper-Mediated Iododeboronation in Water-Alcohol Solvent. ACS Omega. 2023
Yukie Nohara, Keiko Taniguchi, Hiromi Ii, Shun Masuda, Hiroko Kawakami, Masakatsu Matsumoto, Yasunao Hattori, Susumu Kageyama, Toshiyuki Sakai, Susumu Nakata, et al. Development of an activity-based chemiluminogenic probe for γ-glutamylcyclotransferase. Organic & Biomolecular Chemistry. 2023. 21. 29. 5977-5984
Yuki Sugiyama, Seikou Nakamura, Yuichi Tokuda, Masakazu Nakano, Yasunao Hattori, Hiroki Nishiguchi, Yuki Toda, Shigekuni Hosogi, Masayuki Yamashita, Kei Tashiro, et al. 7,8-Dihydroxy-3-(4′-hydroxyphenyl)coumarin inhibits invasion and migration of osteosarcoma cells. Biochemical and Biophysical Research Communications. 2023. 638. 200-209
K. Kobayashi, Y. Hattori, K. Teruya, A. Sanjoh, A. Nakagawa, E. Yamashita, K. Akaji. STRUCTURE ACTIVITY RELATIONSHIP STUDY FOR P1-P1 ' SITE OF TRANSITION STATE MIMIC INHIBITORS FOR BACE1. JOURNAL OF PEPTIDE SCIENCE. 2016. 22. S42-S42
2005 - 2008 Shinshu University Interdisciplinary Graduate School of Science and Technology
2001 - 2003 Shinshu University Graduate School, Division of Agriculture
1997 - 2001 Shinshu University Faculty of Agriculture Bioscience and Biotechnology
Work history (4)：
2016 - Kyoto Pharmaceutical University Instrumental Analysis Center
2011 - Kyoto Pharmaceutical University
2009 - Kyoto Prefectural University of Medicine Graduate School of Medical Science
2008 - 米国National Institutes of Health, Visiting Fellow
Association Membership(s) (5)：
THE JAPANESE CANCER ASSOCIATION
, The Japanese Peptide Society
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN
, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
