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J-GLOBAL ID：200901009245557057 Update date: Jan. 17, 2025

Horie Syunji

HORIE SYUNJI | Horie Syunji

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.p.chiba-u.ac.jp/lab/hinka/index.html

Research field (5)： Physiology , Anatomy , Clinical pharmacy , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (15)：薬効解析 , 和漢薬 , 呼吸器 , 消化器 , 神経薬理学 , 免疫組織化学 , Drug evaluation , Natural medicine , Herbal medicine , Trachea , Lung , Intestine , Stomach , Neuropharmacology , Immunohistochemistry

Research theme for competitive and other funds (34)：

2022 - 2025 Involvement of neuroimmune in TRP channel-related gut hyperreactivity in animal models of functional gastrointestinal diseases
2018 - 2021 Mechanisms for increase of TRP channels in visceral hypersensitivity in inflammatory and functional bowel disease model animals
2015 - 2018 Role of thermo-sensitive TRPV1 and TRPM8 channels in visceral hypersensitivity in inflammatory bowel disease model animals and ulcerative colitis patients
2014 - 2017 Studies on the synthesis of SPECT probe to elucidate the in vivo dynamics of natural opioids
2012 - 2016 Role of thermo-sensitive TRP channels in stress-induced visceral hyperesthesia: analyses of samples from disease model animals and patients

2010 - 2012 Studies on isolation, total synthesis and medicinal chemistryof natural products with regulating activities on memory and pain.

2009 - 2011 Hyperreactivity of thermo-sensitive TRP channel-expressing sensory neurons under stress conditions, and effects of herbal medicines on hyperesthesia

2007 - 2009 Search, asymmetric synthesis, and medicinal chemistry study on the plant alkaloids that regulate the brain nervous system.

2007 - 2008 Hyperesthesia via the alteration of thermo-sensitive TRP channels in animal model of irritable bowel syndrome

2006 - 2007 オピオイド受容体サブタイプを分子標的とする機能性コリナンテ型アルカロイドの開発

2005 - 2006 Involvement of Hot and Cold Receptors in Stress-Induced Disorder of Gastrointestinal Tract

2005 - 2005 モルヒネを超える新規オピオイド性鎮痛アルカロイドの探索と創製

2004 - 2005 ストレス性胃腸運動障害にからむ新規神経ペプチド・ウロテンシンIIの知覚神経刺激

2003 - 2004 Function and distribution of vanilloid receptor TRPVlas non-selective cation channels

2002 - 2004 Development of New Type of Potent Opioid Agonists and the Molecular Mechanism for Exhibiting their Analgesic Activity

2001 - 2002 非興奮性細胞における非選択的カチオンチャネルとしてのバニロイド受容体の機能的役割

2001 - 2002 Cellular and pharmacological studies for protection ofneuronal and endothelial cells

1999 - 2000 分泌細胞の生体機能における容裏性カルシウム流入と非選択的カチオンチャネルの役割

1998 - 2000 Studies on the development of new opioid agonist by utilizing Mitragyna alkaloids as the lead-compounds

1997 - 1998 カルシウム拮抗薬抵抗性カルシウム流入を介する生体反応の解析とその遮断薬の薬理作用

1995 - 1997 Studies on the pharmacological properties of a novel animal model for gastric antral ulcer and on its application to drug evaluation for antiulcer drugs

1994 - 1996 Medicinal Chemistry on Indole Alkaloids from Thai Medicinal Plants

1996 - 知覚神経による消化器機能制御

1996 - Neuromodulation of gastrointestinal function by sensory nerve

1995 - 1995 胃壁細胞のカルシウム動態に作用する化合物の胃酸分泌抑制作用

1994 - 1994 胃壁細胞基底側膜ナトリウム・カリウム輸送機構の胃酸分泌および細胞保護における役割

1993 - 1994 胃壁細胞のPH調節機構に作用する化合物の胃酸分泌抑制および抗消化性潰瘍作用

1991 - 1992 Pharmacological Studies on the Role of Excitatory Amino Acids Receptors in the Hypothalamus in the Control of Gastric Functions.

1991 - 胃酸分泌の中枢性および末梢性制御機構の解析

1987 - 和漢薬とタイ王国伝承民間薬の薬効の薬理学的解析

1987 - Pharmacological evaluation of traditional herbal medicine

トウガラシの生体内作用点カプサイシン受容体と知覚神経に関する研究

Pharmacological study on acid-sensitive receptors such as VR1 and P2X3 receptors in sensory nerve

Central and peripheral regulation of gastric acid secretion

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Papers (80)：

Kimihito Tashima, Syunji Horie. EP24 EFFECT OF APREPITANT ON ALLYL ISHOTHIOCYANATE-INDUCED MUCOSAL INFLAMMATION AND GASTRIC MOTILITY IMPAIRMENT IN THE RODENT STOMACH. Gastroenterology. 2024. 166. 5. S-1512
Noriyuki Ohashi, Kimihito Tashima, Takao Namiki, Syunji Horie. Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats. Journal of pharmacological sciences. 2023. 151. 4. 187-194
中村悠, 田嶋公人, 堀江俊治. 酪酸誘起過敏性腸症候群モデルラットにおける温度感受性TRPチャネルの発現変化と内臓痛覚過敏の関係. 潰瘍. 2022. 49. 30-31
Masatoshi Yoshikubo, Kimihito Tashima, Masaki Raimura, Yuto Watanabe, Yukiko Noma, Syunji Horie. Daikenchuto, a Traditional Kampo Medicine, Facilitates Mucosal Hyperemic Responses through Activation of TRPA1- and TRPV1-Expressing Sensory Nerves in Rat Stomach. Planta Medica International Open. 2022. 9. 01. e72-e79
Tashima Kimihito, Oshige Marina, Fujii Yoko, Horie Syunji. Allyl isothiocyanate-induced acute inflammation in the gastric mucosa leads to the impaired gastric motility in rodents: involvement of substance P and calcitonin gene-related peptide, but not mast cells. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 96. 1-B-P-053

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MISC (181)：

石田菜々美, 川崎翔生, 望月涼平, 堀江俊治, 田嶋公人. Relationship between allyl isothiocyanate-induced mucosal vascular permeability and gastric motility impairment in rodents-the effect of aprepitant-. 日本薬学会年会要旨集(Web). 2024. 144th
吉田祥子, 関吉愛, 田嶋公人, 堀江俊治. Relation between chemical mediators released from mucosal mast cells and TRPM8 in visceral hyperalgesia in the post-inflammatory IBS model mouse. 日本薬学会年会要旨集(Web). 2024. 144th
榎戸雄紀, 吉田祥子, 関吉愛, 田嶋公人, 堀江俊治. 潰瘍性大腸炎寛解期過敏性腸症候群モデルマウスの結腸における内臓痛覚過敏のメカニズム:粘膜型肥満細胞-プロテアーゼ活性化受容体PAR2-温度感受性TRPM8チャネルの関与. 生体機能と創薬シンポジウム要旨集. 2024. 2024
大川拓海, 原沢ひかる, 田嶋公人, 堀江俊治. 抗がん薬シスプラチン誘発悪心嘔吐モデルラットにおけるパイカ行動と小腸粘膜炎症に対するデキサメタゾンの作用. 生体機能と創薬シンポジウム要旨集. 2024. 2024
関吉愛, 中村悠, 田嶋公人, 堀江俊治. Involvement of PAR2-thermosensitive TRPM8 pathway in visceral hyperalgesia in mouse model of post-inflammatory irritable bowel syndrome. 日本薬学会年会要旨集(Web). 2023. 143rd

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Patents (6)：

血管平滑筋弛緩剤
抗アレルギー剤及び抗アレルギー食品
ウコンの抽出エキス及びその医薬用途
Vasorelaxant from herbal medicine
Curcuma longa as an anti-allergy drug and food

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Books (13)：

ファーマシューティカルノート
医学評論社 2003
Introduction-The genus Magnolia(jointly worked)
Medicinal and Aromatic Plants volume 28, Magnolia, Taylor & Francis 2002
胃酸関連疾患の病態と治療(共著)
医学書院 2000
Acid related diseases
2000
幽門洞潰瘍に対するカプサイシン感受性知覚神経の役割(共著)
胃粘膜防御機構におけるカプサイシン感受性知覚神経の役割(医薬ジャーナル社) 1999

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Works (8)：

消化器及び呼吸器における酸感受性受容体の分布
2002 -
附子アルカロイドの冷え改善作用の研究
2000 -
Vasorelaxant effect of Aconite alkaloids
2000 -
FKH6遺伝子ノックアウトマウスにおける胃酸分泌不全の解析
1998 -
ラット幽門洞胃潰瘍病態モデルを中心としたカプサイシン感受性神経の機能的役割
1998 -

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Education (6)：

- 1988 Chiba University
- 1988 Chiba University Graduate School, Division of Pharmaceutical Sciences
- 1987 Toyama Medical and Pharmaceutical University
- 1987 Toyama Medical and Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences
- 1985 Toyama Medical and Pharmaceutical University

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Professional career (1)：

Ph.D (Chiba University)

Work history (12)：

2002 - 2003 Ministry of Education,Culture,Sports,Science and Technology
2000 - 2001 Chiba University Faculty of Pharmaceutical Sciences
2000 - 2001 Ministry of Education and Science,
2000 - 2001 Chiba University, Associate Professor
2001 - - 千葉大学大学院薬学研究院助教授

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Committee career (4)：

1999 - 和漢医薬学会評議員
1999 - 日本薬理学会評議員
1999 - Medical and Pharmaceutical Society of WAKAN-YAKU councilor
1999 - Japanese Pharmacological Society councilor

Association Membership(s) (8)：

実験潰瘍学会 , 和漢医薬学会 , 日本薬学会 , 日本薬理学会 , Japanese Society of Ulcer Research , Medical and Pharmaceutical Society of WAKAN-YAKU , Pharmaceutical Society of Japan , Japanese Pharmacological Society

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