Research field (3)：
Biophysics
, Nanobioscience
, Nanomaterials
Research keywords (8)：
Scanning Probe Microscopy
, Bio-imaging
, High-speed atomic force microscopy
, High-speed AFM
, atomic force microscopy
, motor proteins
, Atomic Force Microscope
, single-molecule analysis
Research theme for competitive and other funds (42)：
2022 - 2026 Development of high-speed AFM capable of filming at 100 frames/s and its demonstrative studies
2020 - 2024 Self-organization and biomechanical properties of the endosomal membrane
2017 - 2022 Materializing nanoscale dynamic imaging of protein molecules in extremely soft membrane environments
2019 - 2020 「動的構造生命科学を拓く新発想測定技術」の成果取りまとめを目指した組織活動
2015 - 2019 Support activities aimed at international network formation in the research area of dynamic structural life sciences
2014 - 2019 New measurement techniques for visualizing live protein molecules at work
2014 - 2019 Development of advanced high-speed AFM and analysis of proteins' action mechanism
2013 - 2019 Dynamic structural biology of protein machineries driven by ATP/GTP
2012 - 2017 New structural biology to be opened by high-speed atomic force microscopy
2012 - 2016 Development of scanner for probe-scan-type of high-speed AFM
2011 - 2014 Visualizing nanometer- scale structural plasticity of synapses in real time using AFM
2011 - 2014 Structural Basis for the chromatin remodeling by nuclear receptors
2009 - 2014 Development of new methods to determine IDP structure
2008 - 2013 International Consortium Program for High-speed Bio-AFM
2008 - 2013 Development of high-speed microscopy capable of capturing fine structures of live cells
2008 - 2012 Innovative high-speed AFM for elucidating vital phenomena
2004 - 2010 Development of instrument for 3D high-resolution dynamics analysis of biological molecules
2004 - 2010 Development of High-speed Imaging Apparatus for Studying Nanometer Scale Dynamic Behavior of Proteins
2005 - 2010 System Cell Engineering by Multi-scale Manipulation
2003 - 2008 Development of a highest-speed atomic force microscope and elucidation of the nano-structural dynamics of biological Molecular motors
2004 - 2005 アクチンに形成される場で無生物は走るか?
2002 - 2003 タンパク質の分子機能動態及び場のリアルタイムイメージングを目指して
2002 - 2002 シャペロニン機能動態のナノイメージング
2000 - 2002 Mechanochechemical Coupling in Brain Myosin V
2000 - 2000 生物分子モーターの構造・機能の1分子動態解析研究
1999 - 1999 生物分子モーターの構造・機能の1分子動態解析研究
1998 - 1999 Visualization of Hydrophobic-, Hydrophilic-, and Charged Areas of Protein by Photochromic Cantilevers.
1998 - 1998 生物分子モーターの構造・機能の1分子動態解析研究
1996 - 1998 1原子・1分子レベルの解析と操作による細胞膜機能の解明
1997 - 1997 生物分子モーターの構造・機能の1分子動態解析研究.
1997 - 1997 ポリマーの結晶化とゲル相転移の研究
1996 - 1996 蛍光プローブ走査型ナノ顕微鏡によるタンパク質表面物性の研究
1994 - 1996 Manufacture of Scanning Force Microscope for Biological Research
1994 - 1996 Molecular Energetics of Protein Motors
1995 - 1995 ヘテロポリマーの物性とprotein foldingへの応用
1994 - 1994 原子間力顕微鏡によるアクトミオシン系の1分子力学特性の研究
1991 - 1993 Development of an Atomic Force Microscope Suitable for Observation of Biological Samples.
1990 - 1991 DIRECTIONAL BROWNIAN MOTION IN UNIFORM HEAT BATH
1989 - 1991 滑りの分子ダイナミックス
1989 - 1991 滑りの分子ダイナミックス
1989 - 1991 滑りの分子 ダイナミックス
1988 - 1988 骨格筋のアクチン繊維鎖に沿う構造変化の伝播-その非対称性
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Papers (190)：
Yuki Yoshioka, Yong Huang, Xiaocen Jin, Kien Xuan Ngo, Tomohiro Kumaki, Meihua Jin, Saori Toyoda, Sumire Takayama, Maiko Inotsume, Kyota Fujita, et al. PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation. The EMBO journal. 2024
Hidenori Homma, Kien Xuan Ngo, Yuki Yoshioka, Hikari Tanaka, Maiko Inotsume, Kyota Fujita, Toshio Ando, Hitoshi Okazawa. PQBP3/NOL7 is an intrinsically disordered protein. Biochemical and Biophysical Research Communications. 2024
Yujia Qiu, Elma Sakinatus Sajidah, Sota Kondo, Shinnosuke Narimatsu, Muhammad Isman Sandira, Yoshiki Higashiguchi, Goro Nishide, Azuma Taoka, Masaharu Hazawa, Yuka Inaba, et al. An Efficient Method for Isolating and Purifying Nuclei from Mice Brain for Single-Molecule Imaging Using High-Speed Atomic Force Microscopy. Cells. 2024. 13. 3. 279-279
Shingo Fukuda, Toshio Ando. Technical advances in high-speed atomic force microscopy. Biophysical Reviews. 2023
Toshio Ando, Shingo Fukuda, Kien X. Ngo, Holger Flechsig. High-Speed Atomic Force Microscopy for Filming Protein Molecules in Dynamic Action. Annual Review of Biophysics. 2023. 53. 1. 19-39
小田隆, 大井里香, 古寺哲幸, 安藤敏夫, 小沼剛, 菅瀬謙治, 苙口友隆, 井上倫太郎, 杉山正明, 石野園子, et al. Integrated approach using small angle X-ray scattering and computational analysis for understanding dynamic structure and function of intrinsically disordered protein. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
ANDO Toshio, ITO Yutaka, SUGITA Yuji, NANGO Eriko, YASUNAGA Takuo, OKADA Yasushi, KANDA Genki N. New Technologies that Propel Biophysics. Seibutsu Butsuri. 2021. 61. 2. 111-118
西出梧朗, 西出梧朗, LIM Keesiang, MOHAMED Mahmoud Shaaban, MOHAMED Mahmoud Shaaban, 小林亜紀子, 小林亜紀子, 羽澤勝治, 羽澤勝治, 中山隆宏, et al. Real-time Imaging of Histone H2A Wrapping Dynamics with DNA Inchworming using High-Speed Atomic Force Microscopy. 日本細胞生物学会大会(Web). 2021. 73rd
西出梧朗, LIM Keesiang, 小林亜紀子, 小林亜紀子, 羽澤勝治, 羽澤勝治, 中山隆宏, 古寺哲幸, 安藤敏夫, WONG Richard, et al. 高速AFMを用いたヒストンH2A-DNA実時空間イメージングによるヌクレオソーム凝縮プロセスとその環境の解明. 日本生化学会大会(Web). 2021. 94th
紺野宏記, 羽澤勝治, 芳坂綾子, 佐々木理乃, 矢幡信成, 古寺哲幸, 安藤敏夫. Investigation of formation process of Prx high molecular weight complexes and its physiological significance. 日本生体エネルギー研究会討論会講演要旨集. 2020. 46th
Directly watching protein molecules in dynamic action by high-speed AFM
(The partnership for structural biology symposium "Dynamics in Structural Biology" 2023)
