Research theme for competitive and other funds (12)：
2021 - 2026 Physiological significance of ultradian oscillatory gene expression
2018 - 2021 Analysis of the mechanisms underlying mammalian brain development and evolution
2015 - 2018 Analysis of the mechanisms underlying the maintenance/differentiation of neural stem cells and brain development/evolution in mammals
2011 - 2013 Analysis of the mechanisms underlying the layer- and region-specificity during brain development
2008 - 2011 Visualizing and dynamic analysis of spiral ganglion cell progenitors b using of human hearing-loss model animals
2008 - 2010 Analysis of the molecular mechanisms regulating the maintenance of multipotency and the dedifferentiation of neural stem cells
2004 - 2006 神経発生及び再生における幹細胞の可視化とニューロン・グリア産生機構の解明
2004 - 2005 Visualization of the neural stem cells and application to the regenerative medicine
2003 - 2004 Molecular analysis for the novel two-hour cycle biological clocks Hes1 and Hes7
2000 - 2000 神経発生分化におけるbHLH型転写因子の役割の解析
神経幹細胞の維持と分化に関する研究
Study on Maintenance and Differentiation of Neural Stem Cells
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Papers (77)：
Akira Kinoshita, Mohammed Shqirat, Ryoichiro Kageyama, Toshiyuki Ohtsuka. Modification of gene expression and soluble factor secretion in the lateral ventricle choroid plexus: Analysis of the impacts on the neocortical development. Neuroscience Research. 2022. 177. 38-51
Mohammed Shqirat, Akira Kinoshita, Ryoichiro Kageyama, Toshiyuki Ohtsuka. Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface. Genes to Cells. 2021
Toshiyuki Ohtsuka, Ryoichiro Kageyama. Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain. Development. 2021. 148. 4
Toshiyuki Ohtsuka, Ryoichiro Kageyama. Dual activation of Shh and Notch signaling induces dramatic enlargement of neocortical surface area. Neuroscience Research. 2021
Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R. Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors. Scientific Reports. 2019. 9. 1. 8251
OHTSUKA Toshiyuki. Embryonic neural stem cells with high levels of Hes1 expression proliferate less frequently and remain as neural stem cells in the postnatal brain. 2018
Toshiyuki Ohtsuka, Ryoichiro Kageyama. Overexpression of Hes1 leads to prolonged neocortical neurogenesis and expansion of neural stem cell reservoir in postnatal brain. ISDN 2018. 2018
Toshiyuki Ohtsuka, Ryoichiro Kageyama. Overexpression of Hes1 leads to prolonged neocortical neurogenesis and expansion of neural stem cell reservoir in postnatal brain. The CDB Symposium 2018. 2018
OHTSUKA Toshiyuki. Hes genes regulate the transition timing of neurogenesis and gliogenesis in neocortical development. 2017
