Rchr

J-GLOBAL ID：200901012092265818 Update date: Nov. 27, 2024

Yoshida Shosei

ヨシダショウセイ | Yoshida Shosei

Affiliation and department：
Job title：教授

Research field (3)： Developmental biology , Cell biology , Molecular biology

Research keywords (6)：生殖細胞 , 分化 , 細胞 , Germ Cells , Differentiation , Cell

Research theme for competitive and other funds (41)：

2023 - 2028 Dynamic reproductive lifespan: Life-long changes and fluctuations in germ cell function and risk for next generation
2023 - 2028 Clonal dynamics in germline for the next generation
2023 - 2026 Cell-cycle property and regulation in mouse sperm stem cells
2018 - 2023 Ensuring integrity of gametogenesis
2018 - 2023 Analysis of repertoire dynamics of germ cell development

2018 - 2021 精巣の精子幹細胞の維持・配偶子産生に関わる新たな分子メカニズムの解明

2016 - 2020 精子形成に至る生殖細胞の選択と競合の解明

2017 - 2019 Study of the selection process of spermatogenic stem cells using genetic barcoding

2017 - 2019 Comprehensive analysis of mouse germ line using genetic barcoding

2017 - 2019 Analysis of mutated spermatogenic stem cell dynamics which cause paternal age effect

2015 - 2018 International joint research on gamete formation through the cutting-edge analysis system

2013 - 2018 Mechanisms regulating gamete formation in animals

2013 - 2018 Investigating the mechanisms for GSC regulation in mouse gametogenesis

2014 - 2017 Elucidation of patterns and regulatory mechanism of undifferentiated spermatogonial motion in mouse testis

2012 - 2016 Analysis of potential stem cells that change their fate from differentiation to self-renewal and support the regeneration of spermatogenesis

2013 - 2015 Homing mechanisms of mouse spermatogenic stem cells following transplantation.

2010 - 2015 "Molecular mechanisms for establishment of sex differences"

2008 - 2014 Regulatory Mechanism of Gamete Stem Cells

2008 - 2013 Investigation of GSC/niche system in the mouse testis

2008 - 2013 Regulatory Mechanism of Gamete Stem Cells

2010 - 2011 A challenge for the Quality Control of Sperm Based on Stem Cell Competition

2008 - 2008 マウス精巣における精子形成幹・前駆細胞ニッチの分子的実体の解明

2008 - 2008 マウス精子形成幹細胞システムを構成する細胞の実体とその機能の解明

2008 - 2008 ほ乳類の精子形成を支える幹細胞システムの細胞生物学的実体の解明

2007 - 2008 生殖戦略の性分化を支えるほ乳類精細管の周期的機能変化のメカニズム

2006 - 2007 ほ乳類精子形成幹細胞の可視化と運命追跡による自己複製機構の解明

2006 - 2007 ほ乳類精子形成を支える幹細胞ニッチの分子的および細胞的実体の解析

2005 - 2006 Role of ngn3, a bHLH transcription factor, in the establishment and maintenance of the mouse spermatogenic stem cells

2004 - 2005 未分化型精原細胞の可視化による精子形成幹細胞システムの解析

2002 - 2004 Molecular analysis of common mechanisms that are crucial for maintenance of hematopoietic stem cells and male germ stem cells.

2002 - 2002 マウス精子形成幹細胞で機能する遺伝子群の系統的探索

2001 - 2002 マウス雄性生殖細胞の減数分裂期に発現する新規bHLH型転写因子の機能解析

2001 - 2001 マウス生殖細胞で機能する転写制御システムの系統的解析

2000 - 2000 マウス生殖細胞で機能する転写因子および細胞表面レセプターの系統的解析

1998 - 2000 Analysis of the Molecular Function of Aging Related Gene ; klotho.

1998 - 1999 骨格筋細胞をモデル系とした幹細胞の形成機構の解析

1996 - 1997 Regulation of cell growth and cell differentiation during muscle development.

ホ乳類雄性生殖細胞の分化制御機構に関する研究

筋細胞の増殖と分化の制御に関する研究

Study on the controling mechanisms of male germ cell differentiation in mammals.

Study on the control of growth and Differentiation of Muscle Cells

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Papers (70)：

Toshiyuki Sato, Yuting I. Li, David J. Jörg, Mitsuru Komeya, Hiroyuki Yamanaka, Hiroko Nakamura, Kodai Hirano, Yohei Kondo, Kazuhiro Aoki, Masahide Takahashi, et al. Self-organization of spermatogenic wave coordinates sustained sperm production in the mouse testis. 2024
Stephen J. Bush, Rafail Nikola, Seungmin Han, Shinnosuke Suzuki, Shosei Yoshida, Benjamin D. Simons, Anne Goriely. Adult Human, but Not Rodent, Spermatogonial Stem Cells Retain States with a Foetal-like Signature. Cells. 2024. 13. 9. 742-742
Mengwen Hu, Yu-Han Yeh, So Maezawa, Toshinori Nakagawa, Shosei Yoshida, Satoshi H Namekawa. PRC1 directs PRC2-H3K27me3 deposition to shield adult spermatogonial stem cells from differentiation. Nucleic Acids Research. 2024
Kanako Ikami, Suzanne Shoffner-Beck, Malgorzata Tyczynska Weh, Santiago Schnell, Shosei Yoshida, Edgar Andres Diaz Miranda, Sooah Ko, Lei Lei. Branched germline cysts and female-specific cyst fragmentation facilitate oocyte determination in mice. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 20. e2219683120
Kodai Hirano, Yuta Nonami, Yoshiaki Nakamura, Toshiyuki Sato, Takuya Sato, Kei-ichiro Ishiguro, Takehiko Ogawa, Shosei Yoshida. Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis. Communications Biology. 2022. 5. 1

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MISC (5)：

原健士朗, 種村健太郎, 吉田松生. 細胞社会の理解が照らし出す組織構築原理マウス精巣における精子幹細胞の動態. 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [3S08-2]
原健士朗, 種村健太郎, 吉田松生. 精細管基底区画における分化軸に沿った精原細胞の局在変化. The Journal of Reproduction and Development. 2015. 61. Suppl. j131-j131
Murine spermatogenic stem cell population and their niche. Cell technology. 2010. 29. 7. 652-657
中川俊徳, 吉田松生. 【生命の永続性を司る生殖細胞サイクル】哺乳類精子形成の継続性を保証する幹細胞メカニズム. 実験医学. 2009. 27. 3. 373-379
吉田松生, 助野真美子, 中川俊徳, 大保和之, 須田年生, 鍋島陽一. マウス精子形成の初期における幹細胞システムと組織構築の成立. 日本発生生物学会大会講演要旨集. 2005. 38回. 145-145

Education (2)：

- 1995 The University of Tokyo
- 1991 The University of Tokyo Faculty of Medicine School of Medicine

Professional career (1)：

Doctor of Medicine (The University of Tokyo)

Work history (10)：

2008/10 - 現在 The Graduate University for Advanced Studies School of Life Science Department of Basic Biology
2008/08 - 現在 National Institute for Basic Biology, National Institutes of Natural Sciences Department of Germ Cell Biology Professor
2014/04 - 2015/03 京都大学大学院理学研究科生物科学専攻動物学教室客員教授
2013/04 - 2015/03 京都大学再生医科学研究所生体組織工学研究部門生体物性学分野客員教授
2013/04 - 2014/03 京都大学ウイルス研究所非常勤講師

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Association Membership(s) (3)：

日本発生生物学会 , 日本分子生物学会 , International Society for Stem Cell Research

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