J-GLOBAL ID:200901012370593562   Update date: Apr. 30, 2010

Ishikawa Toshihisa

イシカワ トシヒサ | Ishikawa Toshihisa
Affiliation and department:
Job title: Professor,Others,Others
Homepage URL  (2): http://www.bio.titech.ac.jp/~tishikaw/http://www.humanABC.bio.titech.ac.jp
Research field  (1): Molecular biology
Research keywords  (1): Xenobiotic Metabolism and Disposition
Research theme for competitive and other funds  (8):
  • Functional Analysis of ABC transporters and their genetic polymorphism
  • Identification of intracellular targets for anti-tumor prostaglandins
  • Toxicogenomic screening for drugs using in vitro liver system
  • 2001 - 2006 In vivo Molecular Science for Discovery of New Biofunctions and Pharmaceutical Drugs
  • 2002 - 2004 design
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MISC (105):
Books (14):
  • Glutathione Conjugates: Transport from the Cell and Intracellular Effects.
    Sakamoto, Y., Higashi, T., Taniguchi, N. and Meister, A. (eds.) Glutathione Centennial: Molecular and Clinical Perspectives, Academic Press, New York 1989
  • Transport of Cysteinyl Leukotrienes.
    Transport of Amino Acids. Haussinger, D. and Kilberg, M. (eds.) Academic Press, New York 1992
  • Glutathione S-Conjugate Export Pump.
    Structure and Function of Glutathione S-Transferases. Tew, K., Pickett, C.B., Mantle, T.J., Mannervik, B. and Hayes, J. (eds.), CRC Press, Boca Raton 1993
  • Glutathione Conjugation and ATP-dependent Export of Anticancer Drugs.
    Drug Transport in Antimicrobial and Anticancer DrugsGeorgopapadakou, N.H. (ed.), Marcel Dekker, New York 1994
  • Transport of Glutathione S-Conjugates from Cancer Cells: Function and Structure of GS-X Pump.
    Vermeulen, N.P.E., Mulder, G.J., Nieuwenhuyse, H., Peters, W.H.M., van Bladeren, P.J. (eds.) Glutathione S-Transferases: Structure, function, and clinical implications. Taylor and Francis, London 1996
Lectures and oral presentations  (2):
  • Intramolecular disulfide bond is a critical checkpoint determining degradative fates of ABC transporter ABCG2 protein.
  • Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2
Works (1):
  • In vivo Molecular Science for Discovery of New Biofunctions and Pharmaceutical Drugs
    2001 - 2006
Education (2):
  • - 1977 Hokkaido University Faculty of Science
  • - 1982 Hokkaido University Graduate School, Division of Natural Science Research Institute of Applied Electricity
Professional career (1):
  • Doctor of Science (Hokkaido University)
Work history (10):
  • 1982 - 1983 University Dusseldorf Deutsher Akademischer Austauschdienst (DAAD) Scholor
  • 1983 - 1987 University Dusseldorf Postdoctoral Fellow
  • 1987 - 1989 Osaka University Medical School Assistant Biochemist
  • 1989 - 1991 German Cancer Reseach Center Project Leader
  • 1991 - 1995 Universty of Texas, M. D. Anderson Cancer Center Assistant Professor
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Committee career (4):
  • 2000 - Chem-Bio Informatics Society
  • 2002 - Genomic Drug Discovery Forum
  • 2008 - Japanese Society for the Study of Xenobiotics
  • 2002 - 2008 The Biochemical Society Biochemical Journal Editorial Board/Advisory panel
Awards (3):
  • 1993 - The 1993 Research Award (International Life sciences Institute, Washington D.C.)
  • 2001 - The First Biobuisiness Competition JAPAN
  • 1982 - Deutscher Akademischer Austauschdienst
Association Membership(s) (8):
Chem-Bio Informatics Society ,  Genomic Drug Discovery Forum ,  The Japanese Biochemical Society ,  Japanese Society for the Study of Xenobiotics ,  New York Academy of science ,  American Association for Cancer Research ,  Gesellschaft fuer Biochemie und Molekularbiologie e.V. ,  The Biochemical Society
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