Sasada Tetsuro

ササダテツロウ | Sasada Tetsuro

Affiliation and department：
Job title： Department director
Homepage URL (1)： http://kcch.kanagawa-pho.jp/kccri/

Research field (4)： Tumor diagnostics and therapeutics , Digestive surgery , General surgery, pediatric surgery , Immunology

Research keywords (7)： Tumor immunolgy , Cancer immunotherapy , Personalized immunotherapy , Cancer vaccine , Neoantigen , Biomarker , Chimeric antigen receptor (CAR) -T cell therapy

Research theme for competitive and other funds (15)：

2023 - 2025 ペプチドミクス解析とシングルセルTCR解析を用いたネオアンチゲン同定法の確立
2022 - 2025 Establishment of an AI-based platform for predicting response to cancer immunotherapy
2021 - 2024 Identification of cancer-specific neoantigens in organoid culture
2019 - 2024 アミノ酸プロファイルによるがん免疫微小環境の代謝リプログラミング評価とがん免疫治療患者層別化技術の開発
2018 - 2020 Analysis of B cell repertoires and their antigen specificity in peripheral blood from cancer patients undergoing anti-PD-1 antibody therapy.

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Papers (179)：

Daiki Murata, Koichi Azuma, Kenta Murotani, Akihiko Kawahara, Yuuya Nishii, Takaaki Tokito, Tetsuro Sasada, Tomoaki Hoshino. Characterization of pre- and on-treatment soluble immune mediators and the tumor microenvironment in NSCLC patients receiving PD-1/L1 inhibitor monotherapy. Cancer immunology, immunotherapy : CII. 2024. 73. 11. 214-214
Shun Horaguchi, Yoshiro Nakahara, Yuka Igarashi, Taku Kouro, Feifei Wei, Kenta Murotani, Seiichi Udagawa, Naoko Higashijima, Norikazu Matsuo, Shuji Murakami, et al. Prognostic Significance of Plasma Neutrophil Extracellular Trap Levels in Patients with Non-Small Cell Lung Cancer Treated with Immune Checkpoint Inhibitors. Biomedicines. 2024. 12. 8
Kazumasa Sekihara, Hidetomo Himuro, Soji Toda, Nao Saito, Ryoichi Hirayama, Nobuyasu Suganuma, Tetsuro Sasada, Daisuke Hoshino. Recent Trends and Potential of Radiotherapy in the Treatment of Anaplastic Thyroid Cancer. Biomedicines. 2024. 12. 6
Hirotaka Nagasaka, Takeshi Kishida, Taku Kouro, Yuka Igarashi, Shinichi Takebe, Shotaro Yamamoto, Takuya Kondo, Mitsuyuki Koizumi, Hideyuki Terao, Takahisa Suzuki, et al. MMP1, IL-1β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors. International journal of clinical oncology. 2024
Feifei Wei, Taku Kouro, Yuko Nakamura, Hiroki Ueda, Susumu Iiizumi, Kyoko Hasegawa, Yuki Asahina, Takeshi Kishida, Soichiro Morinaga, Hidetomo Himuro, et al. Enhancing Mass spectrometry-based tumor immunopeptide identification: machine learning filter leveraging HLA binding affinity, aliphatic index and retention time deviation. Computational and Structural Biotechnology Journal. 2024

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MISC (335)：

洞口俊, 笹田哲朗. がん免疫療法の現状と展望. 日本小児血液・がん学会雑誌. 2023. 60. 3. 192-198
関原和正, 氷室秀知, 平山亮一, 笹田哲朗, 星野大輔. 炭素線照射と分子標的薬の併用は甲状腺未分化がん細胞に対する抗腫瘍効果を相加的に増強する(Combination of carbon ion irradiation and molecular target agents additively enhances the antitumor effect on anaplastic thyroid carcinoma cells). 日本放射線影響学会大会講演要旨集. 2023. 66回. 108-108
中原善朗, 洞口俊, 東公一, 紅露拓, 氷室秀知, 魏菲菲, 眞野恭伸, 辻嘉代子, 神谷郁也, 猶木克彦, et al. ICI治療における血漿中Neutrophil extracellular trapsの効果予測因子としての意義. 肺癌. 2023. 63. 5. 495-495
魏菲菲, 紅露拓, 中村有子, 上田宏生, 氷室秀知, 洞口俊, 辻嘉代子, 眞野恭伸, 中村徳弘, 川村猛, et al. 機械学習を駆使した質量分析によるネオアンチゲンの同定率の向上(HLA-Mascot: Machine Learning-based False Positive Filter in Tumor Immunopeptidomics by Mass Spectrometry). 日本癌学会総会記事. 2023. 82回. 1232-1232
氷室秀知, 中原善朗, 五十嵐友香, 紅露拓, 村上修司, 魏菲菲, 洞口俊, 辻嘉代子, 眞野恭伸, 齋藤春洋, et al. 血漿中の可溶性PD-1およびPD-L1による非小細胞肺がん患者に対する免疫チェックポイント阻害剤の効果予測(Plasma soluble PD-1/PD-L1 for prediction of prognosis in NSCLC patients treated with immune checkpoint inhibitors). 日本癌学会総会記事. 2023. 82回. 1382-1382

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Patents (11)：

がん免疫療法の予後予測のためのバイオマーカー
免疫チェックポイント阻害剤治療の治療選択を補助する指標の評価方法、算出方法、評価装置、算出装置、評価プログラム、算出プログラム、評価システム、及び端末装置
がん免疫療法の治療効果予測に有用な遺伝子多型
新規ネオアンチゲン及びそれらを用いたがん免疫治療薬
Antigen peptide derived from the sequence of epidermal growth factor receptor having T790M point mutation

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Books (12)：

プレシジョン・メディシン ~ビッグデータの構築・分析から臨床応用・課題まで~
エヌ・ティー・エス 2018
がん治療で起こる副作用・合併症の治療法と薬剤開発
技術情報協会 2018
疾患・病態検査・診断法の開発
技術情報協会 2017
ペプチド医薬品のスクリーニング・安定化・製剤化技術
技術情報協会 2017
Cancer Immunology - Cancer Immunotherapy for organ-specific tumors.
Springer-Verlag Berlin Heidelberg 2015

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Education (2)：

- 1997 Kyoto University Graduate School of Medicine Pathology
- 1987 Kyoto University Faculty of Medicine Department of Medical Science

Professional career (1)：

Doctor (Kyoto University)

Work history (9)：

2014/11 - 現在 Kanagawa Cancer Center Cancer Vaccine and Immunotherapy Center, Research Institute Director
2010/04 - 2014/11 Kurume University School of Medicine Department of Immunology and Immunotherapy Associate Professor
2006/04 - 2010/03 Dana-Farber Cancer Institute, Harvard University Cancer Vaccine Center Director of Immune Assessment Core
2001/11 - 2006/03 Tazuke-Kofukai Research Institute Kitano Hospital Department of Surgery Vice director
2001/07 - 2001/11 Kyoto University Hospital Department of Surgery Clinical Fellow

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Committee career (4)：

- 現在日本免疫学会評議員
- 現在日本癌学会評議員
- 現在日本がん免疫学会評議員
- 現在日本遺伝子治療学会評議員

Awards (14)：

2016 - 内藤記念科学振興財団奨励金・研究助成助成金
2015 - 新日本先進医療研究財団研究助成金
2014 - 東京生化学研究会研究助成金
2013 - 多発性骨髄腫研究助成
2013 - がん集学的治療研究財団第33回一般研究助成

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Association Membership(s) (10)：

American Society of Clinical Oncology , Society for Immunotherapy of Cancer , American Association for Cancer Research , Japanese Association of Cancer Immunology , Japan Society of Gene and Cell Therapy , Japanese Society for Immunology , Japan Society of Clinical Oncology , Japanese Cancer Association , Japanese Society of Gastroenterological Surgery , Japan Surgical Society

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