Rchr

J-GLOBAL ID：200901013523817011 Update date: Jun. 21, 2024

Shirakawa Hitoshi

シラカワヒトシ | Shirakawa Hitoshi

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.agri.tohoku.ac.jp/jp/about/organization/graduate/eiyo/index.html , https://www.agri.tohoku.ac.jp/en/about/organization/graduate/eiyo/index.html

Research field (2)： Applied biochemistry , Food sciences

Research keywords (6)：健康寿命 , rice bran , chromatin , transcription regulation , life style related disease , vitamin

Research theme for competitive and other funds (65)：

2003 - 現在米糠抽出物による生活習慣病予防効果
1999 - 現在ビオチンの生活習慣病善作用
1999 - 現在 Molecular-nutritional analysis of vitamin K and isoprenoids
1988 - 現在 Structure and function of HMG chromosomal proteins
2023 - 2026 生体内変換型ビタミンKによる抗老化作用とその作用機序に関する研究

2023 - 2026 潜在的ビタミンB6欠乏による腎障害増悪機序の解明

2023 - 2026 Analysis of genetic polymorphisms of bitter taste receptor TAS2R38 and glutathione-S-transferase (GST), and its relationship with eating habits in Japanese megabank database

2023 - 2026 牛乳房炎発症予防法と抗病性育種の開発事業

2023 - 2025 苦味受容体を介した苦味成分の新たな健康機能性

2022 - 2025 うま味感受性を利用したフレイルとサルコペニア肥満の攻略法の開発ー骨格筋量の改善ー

2022 - 2025 The study for the augmentation of happiness via food selection behavior and mental by subjective and objective evaluations

2021 - 2025 魚類における酸化的ストレスの評価に特化したバイオマーカーの開発と健魚育成への応用

2021 - 2024 Increasing effect of cyclophilin A on somatic cell counts in milk of dairy cow

2020 - 2023 脳内活性型ビタミンKの認知機能増強作用と作用機序の解析

2020 - 2023 Development of therapeutic strategy against congestive heart failure by food ingredients.

2017 - 2023 妊娠期ラットの潜在的亜鉛欠乏が育児行動およびホルモン分泌に及ぼす影響

2019 - 2022 Elucidation of Improvement of quolity of life (QOL) in the aged subjects through oral zinc ingestion

2018 - 2022 Mechanism of action of oxidative environmental stress on fish health and its control based on scientific evidence

2018 - 2020 Cancer risk assessment study on gene polymorphism of bitter taste receptor TAS2R38 and glutathione-S-transferase by analyzing ToMMo data

2017 - 2020 Novel function of menaquinone-4 in brain

2016 - 2019 An Action Research on Social Implementatin of "Food & Agricultural Immunology" by Integration of Social and Natural Sciences

2015 - 2017 Genetic polymorphism of bitter taste receptor TAS2R and hepatic detoxification enzyme GST.

2014 - 2017 A study on the mechanisms of energy production in super salmon and its appl ication for cultured fish

2014 - 2017 Effect of activated vitamin K analogue on endocrine function

2013 - 2016 Effect of exercise for weight control that applied circadian rhythm

2013 - 2015 Correlation analysis of genetic polymorphism of human bitter-taste receptor TAS2R and that of hepatic detoxification enzyme GST

2013 - 2015 Novel funcion of biotin on testosteron production

2011 - 2015 Clarification of novel functions of menaquinone-4 converted from vitamin K1 in animal organs

2011 - 2015 Role of zinc supplementation on improving activity of taste abnormality and anorexia

2012 - 2014 Analysis of glucose-related metabolites as a novel functional component in fruit

2011 - 2013 A study on the mechanisms of appetite regulation in super salmon and its application for aquaculture

2011 - 2012 Inter-relationship analysis of genetic polymorphism of human bitter-taste receptor TAS2R and hepatic detoxification enzyme GSTs

2011 - 2012 The study of novel regulatory mechanism for the expression of fatty acid synthase gene in re-feeding state of rat liver

2008 - 2010 A study on the mechanisms of growth in super salmon and its application for improvement of muscle production

2008 - 2010 Clarification of dietary zinc signal transduction through the intestine to the appetite control region of brain.

2008 - 2010 Physiological role of vitamin K2 (manaquinone-4) that is generated from other vitamin K analogues in animal organs

2008 - 2009 ヒト苦味・渋味感受性の個人差と遺伝子多型の関係の解析

2007 - 2008 糖尿病および心血管疾患を改善する食品中成分のニュートリノジェノミクス解析研究

2006 - 2007 Physiological role of vitamin K2 (manaquinone-4) that is converted from other vitamin K analogue in animal organs

2005 - 2007 Study for involvement of lipid glycation in food deterioration and living senescence

2005 - 2006 苦味および渋味感受性に及ぼす唾液中成分ならびに味覚レセプターの遺伝子多型の影響

2004 - 2005 CLARIFICATION OF THE BIOLOGICAL MEANING OF MENAQUINONE-4 SYNTHESIS IN ANIMAL ORGANS

2003 - 2005 Physiological study on the role of zinc enzyme on the improvement of taste disorders

2002 - 2003 CLARIFICATION OF THE MECHANISM OF ANIT-DIABETIC EFFET BY THE ADMINISTRATION OF BIOTIN

2001 - 2002 ビタミン、ミネラルの新しい生理作用の検察-DNAマイクロアレーを用いた解析-

2001 - 2002 Clarification of a novel physiological function of menaquinone-4 (vitamin K2), a postulated active form of vitamin K in various tissues

1999 - 2000 Clarification of the conversion mechanism of vitamin K analogues to menaquinone-4, a potent hormone-like substance, in the rat tissues.

1997 - 1998 The functions and their mechanisms of DNA-binding proteins, HMG1 and HMG2

1997 - 1997 核タンパク質HMG1による転写促進機構の外来遺伝子クロマチンレベルにおける解析

1997 - 1997 HMGタンパク質のDNA結合ドメイン構造と認識機構の解析

1996 - 1996 DNA結合性タンパク質HMG1による転写促進機構のクロマチンレベルにおける解析

1996 - 1996 HMGタンパク質のDNA結合ドメイン構造と認識機構の解析

1995 - 1996 Studies on DNA-binding, transcriptional stimulation and role in cell proliferation of HMG proteins.

1995 - 1995 転写制御因子HMG1高発現細胞を用いた有用遺伝子高発現系の開発

1995 - 1995 HMGタンパク質のDNA結合ドメイン構造と認識機構の解析

1994 - 1994 HMGタンパク質のDNA結合機構および機能解析研究

1994 - 1994 HMGタンパク質のDNA結合ドメイン構造と認識機構の解析

1993 - 1993 転写調節因子HMG2の癌遺伝子産物による転写促進機構の解析

1993 - 1993 HMGboxのDNA結合機構および転写反応における役割の研究

1992 - 1992 転写調節因子HMGZの癌遺伝子産物による発現促進機構の解析

1991 - 1992 STUDIES ON TRANSCRIPTION PROGRESSION FACTORS AND THE APPLICATION

1990 - 1992 核蛋白質による十字型DNA構造の特異的識別・結合の様式および同構造解消の機構

1991 - 1991 DNA結合性タンパク質HMGIによる培養細胞への外来遺伝子導入・発現の効率化

1990 - 1991 核タンパク質による十字型DNA構造の特異的識別・結合の様式および同構造解消の機構

1990 - 1990 核蛋白質による十字型DNA構造の特異的識別・結合の様式および同構造解消の機構

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Papers (145)：

Md Alauddin, Md Ruhul Amin, Muhammad Ali Siddiquee, Kazuyuki Hiwatashi, Atsushi Shimakage, Saori Takahashi, Mamoru Shinbo, Michio Komai, Hitoshi Shirakawa. In silico and in vivo experiment of soymilk peptide (tetrapeptide - FFYY) for the treatment of hypertension. Peptides. 2024. 175. 171170-171170
Fang Yu Hsu, Suh Ching Yang, Fat Moon Suk, Hitoshi Shirakawa, Wan Chun Chiu, Yi Jen Liao. Dietary rice bran attenuates hepatic stellate cell activation and liver fibrosis in mice through enhancing antioxidant ability. Journal of Nutritional Biochemistry. 2024. 125
Vi Vi Tang Kang Wee, Hitoshi Shirakawa, Sung Ling Yeh, Chiu Li Yeh. Fermented rice bran supplementation attenuates colonic injury through modulating intestinal aryl hydrocarbon receptor and innate lymphoid cells in mice with dextran sodium sulfate-induced acute colitis. Journal of Nutritional Biochemistry. 2024. 123
Tomoko Imoto, Yuichiro Hoshino, Yoshiyuki Sato, Yusuke Ohsaki, HITOSHI SHIRAKAWA. Eating Habits and Mental Health of College Students in Japan during the COVID-19 Pandemic. COVID. 2023
Michiko YAMAKI, Hiroki SAITO, Takahiro MIMORI, Yoichi SUZUKI, Masao NAGASAKI, Kichiya SUZUKI, Shizuko SATOH-KURIWADA, Noriaki SHOJI, Kunio ISONO, Tomoko GOTO, et al. Analysis of Genetic Polymorphism of Bitter Taste Receptor TAS2R38 and TAS2R46, and Its Relationship with Eating and Drinking Habits in Japanese ToMMo Subjects. Journal of Nutritional Science and Vitaminology. 2023

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MISC (78)：

Michio Komai, Dan Takeno, Chiharu Fujii, Joe Nakano, Yusuke Ohsaki, Hitoshi Shirakawa. Nailfold Capillaroscopy: A Comprehensive Review on Its Usefulness in Both Clinical Diagnosis and Improving Unhealthy Dietary Lifestyles. Nutrients. 2024. 16. 12. 1914-1914
塩沢浩太, 大崎雄介, 白川仁. 新規形態のビオチン塩の開発とその効果. ビタミン. 2024. 98. 21-24
大崎雄介, Afifah Zahra Agista, 白川仁. 糖尿病と高血圧に対して期待されるビオチンの効果. ビタミン. 2023. 96. 474-476
Hsin-Jung Ho, Hitoshi Shirakawa. Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease. Cells. 2022. 12. 1. 88-88
Halima Sultana, Michio Komai, Hitoshi Shirakawa. The role of vitamin K in cholestatic liver disease. Nutrients. 2021. 13. 8

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Patents (25)：

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Books (10)：

豆類の百科事典
朝倉書店 2024 ISBN:9784254400267
米の機能性食品化と新規利用技術・高度加工技術の開発
2022
食品免疫学事典
朝倉書店 2021 ISBN:9784254431261
ビタミン・バイオファクター総合事典
朝倉書店 2021 ISBN:9784254102925
ビタミン・バイオファクター総合事典
朝倉書店 2021 ISBN:9784254102925

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Lectures and oral presentations (69)：

Novel functions of vitamins for the health promotion.
(The Symposium for Pharmaceutical Sciences between Tohoku University and National Yang Ming Chiao Tung University 2023)
Novel functions of vitamin K and biotin to extend healthy life expectancy.
(National Seminar and Congress ISFFN 2023 2023)
The effect of fermented rice bran on lifestyle related diseases
(2023)
長寿時代の健康とビタミン
(最先端エイジングセミナー 2022)
The effect of food Ingredient from Melinjo seed extract on nonalcoholic fatty liver disease in mice
(2nd International Conference for Smart Agriculture, Food, and Environment (ICSAFE) 2021)

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Professional career (2)：

農学修士 (Tohoku University)
Ph.D. (Tohoku University)

Committee career (13)：

2023/06 - 現在日本ビタミン学会理事
2022/06 - 現在日本栄養・食糧学会理事・東北支部支部長
2019/01 - 現在日本無菌生物ノートバイオロジー学会常任理事
2006/05 - 2024/05 日本ビタミン学会編集員会トピックス等担当委員
2013/11 - 2023/05 日本ビタミン学会代議員

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Awards (2)：

2024/06 - 日本ビタミン学会学会賞ビタミンKおよび関連イソプレノイドのもつ新たな健康機能性に関する研究
2004/08/26 - 日本農芸化学会東北支部日本農芸化学会東北支部奨励賞ヌクレオソーム結合タンパク質による遺伝子発現調節機構の研究

Association Membership(s) (5)：

日本ビタミン学会 , 日本無菌生物・ノートバイオロジー学会 , 日本栄養食糧学会 , 日本分子生物学会 , 日本農芸化学会

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