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Rchr
J-GLOBAL ID：200901015249205708
Update date: Mar. 25, 2025 Sato Takashi
サトウ タカシ | Sato Takashi
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Kumamoto University
About Kumamoto University
Job title： Assistant Professor
Homepage URL (1)： http://seimeibunseki.org
Research theme for competitive and other funds (10)：
- 2024 - 2027 小型抗体の血中滞留性をコントロールできる脂肪酸構造の評価研究
- 2021 - 2024 ATTRアミロイドーシスの加齢依存的な発症を制御する環境要因の同定
- 2018 - 2021 Elucidation of the molecular mechanism underlying TTR monomer unfolding and aggregate formation and its application to therapeutic approaches for FAP
- 2017 - 2020 Developments of functional single-chain antibodies and unraveling of mechanisms of diseases associated with advanced glycation end-products
- 2016 - 2018 Development of highly sensitive imaging method by use of functional single-chain antibodies that discriminate the structure of advanced glycation endproduct
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- Sena Kamesawa, Mizuki Ogawa, Yoshiki Funakoshi, Masaya Kato, Shosei Kai, Mana Namikawa, Kyo Okazaki, Takashi Sato, Yoshihiro Kobashigawa, Hiroshi Morioka. Evaluation of the cyclic single-chain Fv antibody derived from nivolumab by biophysical analyses and in vitro cell-based bioassay. Journal of biochemistry. 2024
- Yan Du, Yoshihiro Kobashigawa, Kyo Okazaki, Mizuki Ogawa, Tomoyuki Kawaguchi, Takashi Sato, Hiroshi Morioka. Structure-based design, biophysical characterization, and biochemical application of the heterodimeric affinity purification tag based on the Schistosoma japonicum glutathione-S-transferase (SjGST) homodimer. The Journal of Biochemistry. 2024
- Yuki Inada, Yuichiro Ono, Kyo Okazaki, Takuma Yamashita, Tomoyuki Kawaguchi, Shingo Kawano, Yoshihiro Kobashigawa, Shoko Shinya, Chojiro Kojima, Tsuyoshi Shuto, et al. Hydrogen bonds connecting the N-terminal region and the DE loop stabilize the monomeric structure of transthyretin. Journal of biochemistry. 2023. 174. 4. 355-370
- Kyo Okazaki, Yoshihiro Kobashigawa, Hikari Morita, Soichiro Yamauchi, Natsuki Fukuda, Chenjiang Liu, Yuya Toyota, Takashi Sato, Hiroshi Morioka. Molecular Dynamics-Based Design and Biophysical Evaluation of Thermostable Single-Chain Fv Antibody Mutants Derived from Pharmaceutical Antibodies. ACS Omega. 2023
- Ryoko Sasaki, Mary Ann Suico, Keisuke Chosa, Yuriko Teranishi, Takashi Sato, Asuka Kagami, Shunsuke Kotani, Hikaru Kato, Yuki Hitora, Sachiko Tsukamoto, et al. Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors. Journal of Pharmacological Sciences. 2023. 151. 1. 54-62
- 岡崎匡, 久米田博之, 佐藤卓史, 小橋川敬博, 森岡弘志. 次世代型抗体の創製に向けた高品質な一本鎖抗体のIn silico設計. 次世代を担う若手のためのファーマ・バイオフォーラム講演要旨集. 2024. 23rd
- 小橋川敬博, DU Yan, 岡崎匡, 小川瑞葵, 川口智行, 佐藤卓史, 森岡弘志. Structure-based design of the GST-tag hetero-dimer, and its biophysical characterization, and biochemical applications. 日本蛋白質科学会年会(Web). 2024. 24th
- 亀澤世奈, 楊一帆, 小川瑞葵, 甲斐勝成, 並河真菜, 岡崎匡, 時瑞, 山内聡一郎, 佐藤卓史, 小橋川敬博, et al. 環状一本鎖抗体を基盤とした二重特異性抗体の作製および機能評価. 日本蛋白質科学会年会(Web). 2024. 24th
- 岡崎匡, 佐藤卓史, 小橋川敬博, 森岡弘志. In silico創薬に基づく凝集性を抑制した一本鎖抗体の創製. 日本蛋白質科学会年会(Web). 2024. 24th
- 亀澤世奈, 永田貴子, SUNGWAN Prin, 佐藤卓史, 小橋川敬博, 岡田誠治, 森岡弘志. In vivo antitumor activity evaluation of Bispecific T-cell engaging antibodies based on cyclic single-chain variable fragment. 日本抗体学会学術大会プログラム・抄録集(Web). 2024. 3rd
Professional career (1)：
- 博士(薬学) (熊本大学)
- 2012 - 2015 Kumamoto University Institute of Molecular Embryology and Genetics
- 2015 - Kumamoto University Faculty of Life Sciences
- 2015 - Assistant Professor,Faculty of Life Sciences(Pharmaceutical sciences group),Kumamoto University
- 2011 - 2012 Fukushima Medical University School of Medicine, Institute of Biomedical Sciences
- 2011 - 2012 Assistant Professor
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