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Co-authoring Researcher

Oikawa Shinji
Mie University Graduate School of Medicine, Department of Environmental and Molecular Medicine
酸化ストレス, 神経変性疾患, 発がん機構, aging, carcinogenesis
Kobayashi Hatasu
Mie University
衛生学, 予防医学, 遺伝疫学, 環境衛生, 社会医学, RNF213, 脳血管疾患, 変異原物質, DNA損傷, 酸化ストレス
Arima Yasushi
Suzuka University of Medical Science Faculty of Health Science
inflammation and carcinogensis, Taurine, 細胞組織学微細形態, 免疫組織細胞化学, Cellular Histological Micromorphology, Immunocytochemistry

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J-GLOBAL ID：200901015936458349 Update date: Feb. 21, 2025

Murata Mariko

ムラタマリコ | Murata Mariko

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Affiliation and department：
Job title： Professor

Research field (3)： Healthcare management, medical sociology , Hygiene and public health (non-laboratory) , Hygiene and public health (laboratory)

Research keywords (4)：公衆衛生学・健康科学 , 衛生学 , Public health・Health science , Hygiene

Research theme for competitive and other funds (54)：

2021 - 2024 果糖は発がんおよびその進展にどう作用するのか?
2019 - 2023 認知症における血中エクソソーム内包酸化損傷タンパク質の変動解析とリスク診断
2019 - 2023 Mechanism of epigenetic aberration in inflammation-related carcinogenesis: molecular epidemiology by a comparison of risk factors between Japan and China
2019 - 2022 Roles of DAMP and autophagy in inflammation-related carcinogenesis and its application to cancer prevention
2019 - 2022 An Empirical Study on the Effect of Improvement of Operating Room Noise Environment on Health and Cognitive Behavioral Function of Medical Workers

2019 - 2021 Can a dietary factor taurine suppress carcinogenesis?

2018 - 2021 Clarification of the role of DAMP in health effects caused by particulate matters and risk assessment

2017 - 2020 A comparative molecular epidemiology study of carcinogenicity on the liver flube infection in the Xijiang (China) and Mekong river (Thailand)

2016 - 2020 途上国におけるアルツハイマー病発症リスクの検証: 食と環境との関わり

2016 - 2019 Carcinogenic mechanisms of stem cells in inflammation-related cancer and its prevention

2016 - 2019 Establishment of early diagnostic markers for nasopharyngeal carcinoma and experimental verification through fieldwork in southern China

2015 - 2018 Development of minimal-invasive and quantitative analytical method for nitrated DNA damage, and its application to risk assessment of inflammation-related carcinogenesis

2015 - 2017 Reset of the epigenetic abnormality by dietary factors for cancer prevention

2014 - 2017 Proteomic profiling of exosomal proteins for the early diagnosis of Alzheimer's disease and prevention of Alzheimer's disease

2013 - 2016 Epigenetic alteration in inflammation-related carcinogenesis and its application to cancer prevention and therapy

2013 - 2016 Development of screening methods for early detection of nasopharyngeal carcinoma in southern China

2013 - 2015 炎症関連発がんにおけるエピゲノム異常の機構解明とがん予防・治療への応用

2011 - 2014 Development of risk assessment methods for parkinson's disease using carbonylated protein, a protein oxidation product, as a predictive indicator

2011 - 2013 Evaluation and prevention of Alzheimer's disease associated with lifestyle and dietary habit factors in the developing country.

2011 - 2012 Roles of microRNA in inflammation-related carcinogenesis and its possibility for use as a biomarker

2010 - 2012 Molecular mechanism of infection/inflammation-associatedcarcinogenesis and cancer prevention

2010 - 2012 A molecular epidemiological study to explore arsenic relation carcinogenesis and malignant progression in an arsenic endemic rural region in Shanxi province of China

2010 - 2012 Molecular epidemiology of nasopharyngeal carcinoma in southern Chinaand searching for early detection biomarkers

2009 - 2011 Risk assessment of carcinogenicity and fibrogenicity in respiratory systems induced by fibrous and particulate materials

2009 - 2011 Molecular epidemiological study on cholangio-carcinogenesis induced by liver fluke Opisthorchis viverrini in Thailand.

2008 - 2010 Mechanism of neuronal death induced by oxidative stress in Parkinson's disease

2007 - 2009 Roles of obesity and dietary factors on multistage carcinogenesis and risk assessment

2007 - 2009 Molecular epidemiology study on carcinogenic mechanism of Epstein-Barr-associated nasopharyngeal carcinoma and modification by environmental factors in southern China

2007 - 2008 感染症・炎症に起因する発がんの新規バイオマーカーの開発とがん予防

2006 - 2008 Development of the biomarker analysis system for evaluating the risk of carcinogenesis related to infection and inflammation

2006 - 2008 Molecular epidemiological study for bladder carcinogenesis induced by parasite in Egypt

2005 - 2008 Research of Incidence and Risk Factor of Alzheimer's Disease and Life-Style Related Disease

2005 - 2007 Functional proteomic analysis of oxidatively modified proteins associated with senescence acceleration and prevention of pathological aging

2005 - 2006 Mechanism of carcinogenesis in female reproductive organs induced by environmental estrogens

2005 - 2006 Evaluation of the efficacy and safety of antioxidant supplements on the basis of oxidative DNA damage profiles

2003 - 2005 The mechanism for the formation of hotspots in relation to evaluation of carcinogenic risks of environmental chemicals

2003 - 2005 Molecular epidemiological study on the pathogenesis of cholangiocarcinoma caused by infection with liver flukes in Thailand

2002 - 2003 環境化学物質の内分泌撹乱作用と遺伝毒性の発現機構

2001 - 2003 Development of evaluation system for cancer chemopreventive agents based on DNA damage inhibition and gene expression

2000 - 2002 Analysis of sequence-specific DNA damage by oxidative stress and prevention of cancer and aging

2001 - 2001 環境化学物質の内分泌撹乱作用と遺伝毒性の発現機構

2000 - 2001 Analysis of the human DNA damage by dietary factors via reactive oxygen species and cancer prevention

1999 - 2001 Evaluation of toxicity of environmental chemicals on the basis of their estrogenic activity and DNA-damaging ability and regional risk assessment

1998 - 2000 The method of safety evaluation of chemopreventive agents based on the ability of damaging human genes

1997 - 1999 Mechanisms of DNA damage induced by environmental factors and cancer chemoprevention

1998 - 1998 太陽紫外線特にUVAによる遺伝子損傷機構の解析

1997 - 1998 Analysis of the human DNA damageby antioxidants for evaluation of safety in cancer chemoprevention

1997 - 1997 NOと活性酸素の発がんにおける役割

1994 - 1996 Clinical study of postnatal depression. -The impact on child development-

1988 - 1990 Studies on the Effects of Infrasound on Vestibular Function.

1985 - 1986 Studies on the successive effects of noise exposure to pregnant mice

Mechanisms of carcinogenesis induced by environmental factors

Study on mental health for mother and child

Study on teratogenic effects of noise

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Papers (182)：

Yurie Mori, Rinya Yogo, Hatasu Kobayashi, Hirotaka Katsuzaki, Yuichiro Hirao, Shinya Kato, Hirokazu Kotani, Shosuke Kawanishi, Mariko Murata, Shinji Oikawa. Reactive oxygen species-mediated cytotoxic and DNA-damaging mechanism of N4-hydroxycytidine, a metabolite of the COVID-19 therapeutic drug molnupiravir. Free radical research. 2025. 1-34
Yusuke Hiraku, Akiyo Tanaka, Masato Yamamoto, Minori Nakatani, Mayu Kobayashi, Eiki Kimura, Sharif Ahmed, Mariko Murata. Microarray analysis of gene expression in lung tissues of indium-exposed rats: possible roles of S100 proteins in lung diseases. Archives of toxicology. 2024
Waleeporn Kaewlert, Chadamas Sakonsinsiri, Worachart Lert-Itthiporn, Panupong Mahalapbutr, Saba Ali, Thanyada Rungrotmongkol, Apinya Jusakul, Napat Armartmuntree, Chawalit Pairojkul, Guofei Feng, et al. Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024. 180. 117569-117569
Guifeng Wang, Keiichi Hiramoto, Ning Ma, Shiho Ohnishi, Akihiro Morita, Yifei Xu, Nobuji Yoshikawa, Yasuo Chinzei, Mariko Murata, Shosuke Kawanishi. Immunohistochemical analyses reveal FoxP3 expressions in spleen and colorectal cancer in mice treated with AOM/DSS, and their suppression by glycyrrhizin. PLOS ONE. 2024. 19. 8. e0307038-e0307038
Hatasu Kobayashi, Yuichiro Hirao, Shosuke Kawanishi, Shinya Kato, Yurie Mori, Mariko Murata, Shinji Oikawa. Rosmarinic acid, a natural polyphenol, has a potential pro-oxidant risk via NADH-mediated oxidative DNA damage. Genes and Environment. 2024. 46. 1

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MISC (224)：

馮国飛, 有馬寧, 翠川薫, 及川伸二, 小林果, Zhao Weilin, Zhang Zhe, 竹内万彦, 村田真理子. トランスフェリン受容体のノックダウンは上咽頭癌の細胞増殖および浸潤を抑制する(Knockdown of transferrin receptor suppresses cell proliferation and invasion of nasopharyngeal carcinoma). 日本癌学会総会記事. 2022. 81回. P-1290
Effect of RNF213 suppression on endoplasmic reticulum stress. 2022. 77. Suppl. S184-S184
王桂鳳, 平本恵一, 有馬寧, 大西志保, 村田真理子, 川西正祐. グリチルリチンによる発がん抑制に伴うマウス脾臓の免疫細胞への影響. 日本衛生学雑誌. 2022. 77. Suppl. S219-S219
岡野元彦, 何峰, 有馬寧, 小林果, 及川伸二, 西村廣明, 俵功, 村田真理子. 上咽頭癌細胞のオートファジー及びアポトーシス関連分子発現に対するタウリンの影響. 日本衛生学雑誌. 2022. 77. Suppl. S220-S220
Feng Guofei, He Feng, 有馬寧, 翠川薫, 及川伸二, 小林果, 竹内万彦, 村田真理子. GDF10はTGF-β/Smad/NF-κB経路を介して上咽頭癌の進展を抑制する. 日本衛生学雑誌. 2022. 77. Suppl. S222-S222

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Books (8)：

腫瘍薬学
南山堂 2010
子どもの保健-理論と実践-
日本小児医事出版社 2010
食品機能性の科学
食品機能性の科学編集委員会 2008
環境エストロゲンによる生殖器系発がんの機構解明とリスク評価
[村田真理子] 2007
食餌性因子による活性酸素を介するヒト遺伝子損傷の解析とがん予防
[村田真理子] 2002

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Lectures and oral presentations (84)：

アクリルアミド代謝産物による塩基配列特異的DNA損傷機構
(第91回日本衛生学会学術総会 2021)
甘草の主成分グリチルリチンはAOM+DSS誘導性大腸がんを抑制する
(第91回日本衛生学会学術総会 2021)
Knockdown of transferrin receptor 1 inhibits cell proliferation in nasopharyngeal carcinoma
(2021)
Downregulation of GLUT5 suppresses cell proliferation and migration in cholangiocarcinoma cells
(2021)
Rnf213抑制はオスAkitaマウスと異なりメスAkitaマウスの糖尿病を改善しない
(第91回日本衛生学会学術総会 2021)

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Education (1)：

- 1984 Mie University Faculty of Medicine

Professional career (1)：

(BLANK)

Work history (3)：

2024/06 - 現在 Mie University
2024/04 - 現在 Suzuka University of Medical Science Graduate School of Health Science Professor
2006/12 - 2024/03 Mie University Graduate School of Medicine Department of Environmental and Molecular Medicine Professor

Awards (2)：

2021/03 - 日本衛生学会 Environmental Health and Preventive Medicine(国際誌)Editor-in-chief Award
2018/03 - The Japanese Society for Hygiene -

Association Membership(s) (6)：

日本癌学会 , 日本健康教育学会 , 生理人類学会 , 日本産業衛生学会 , 日本公衆衛生学会 , 日本衛生学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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