Research keywords (3):
Bacteriology
, Immunology
, Infectious Diseases
Research theme for competitive and other funds (25):
2021 - 2024 Analysis of type 3 immune responses against M. tuberculosis infection and application to boost vaccine
2020 - 2023 Analysis of molecular mechanism of mitochondrial damage and immune suppression induced by Mycobacterium tuberculosis
2018 - 2022 Analysis of multiple defense mechanisms of "type 3 immune response" in mycobacteria infected lungs
2018 - 2021 A role of TAB3 in host defense against mycobacterial infection
2015 - 2019 Involvement of IL-17 cytokine family in protective immunity to pulmonary mycobacterial infection.
2015 - 2018 Regulation of innate immune response to mycobacteria through the recognition of immunoregulating cell wall lipids by ITAM-coupled receptors
2013 - 2016 Analysis of mechanism of T cell targeting into Mycobacterium tuberculosis-infected lung and development of new lung-targeting vaccine strategy
2012 - 2015 Role for novel innate immune receptors for pulmonary pathogens
2011 - 2015 Phenotypic analysis of Rap2 knockout mice
2011 - 2015 IL-17-mediated regulation of a granuloma formation in pulmonary mycobacterial infection.
2009 - 2012 New role of interleukin-17 in protective immunity against intracellular bacterial infections and its application
2008 - 2010 The elucidation of host defense mechanisms of Mycobacterium tuberculosis infection and the architecture of cytokine-network.
2008 - 2010 Crosstalk between epithelial barrier function and cytokine signaling during salmonella infection
2006 - 2009 Analysis of induction and activation mechanism of protective CD8 T cells against pulmonary tuberculosis and application for the development of anti-tuberculosis vaccine
2004 - 2007 Analysis of immune system in Mycobacterium tuberculosis-infected lung and vaccine development.
2001 - 2005 サイトカインのシグナル制御機構とその破綻
2000 - 2001 SELECTIVE GENE TRGETING OF TCR Vδ GENES AND ANALYSIS OF THE KNOCKOUT MICE
1999 - 1999 T細胞の分化および活性化におけるApaf1依存性アポトーシス機構の解析
1998 - 1999 GENE TARGETING OF PROTEIN TYROSINE PHOSPHATASE PTP-J
1995 - 1996 Induction of drug induced tolerance in mice and application for large animals
1995 - 1995 遺伝子ターゲティングマウスにおける免疫応答異常の解析
1994 - 1994 特異遺伝子欠損マウスにおける免疫応答異常の解析
1993 - 1994 The role of stress protein-reactive gammadeltaT cells in infection
1991 - 1991 自己反応性熱ショック蛋白反応性T細胞の抗腫瘍活性の検討
1991 - 1991 γδ型T細胞レセプターを発現した自己反応性T細胞の生体防御機構における役割
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Papers (184):
Tanveer Ali, Huong Minh Nguyen, Naeem Abbas, Osamu Takeuchi, Shizuo Akira, Toshihiko Suzuki, Goro Matsuzaki, Giichi Takaesu. TAK1-binding protein 2 (TAB2) and TAB3 are redundantly required for TLR-induced cytokine production in macrophages. International Immunology. 2024
豊永 憲司, 梅村 正幸, 松崎 吾朗, 原 博満, 田中 芳彦, 山崎 晶. 抗酸菌感染におけるCard9の機能解析(Analysis of Card9 function in pulmonary mycobacterial infection). 日本細菌学雑誌. 2022. 77. 1. 101-101
Tomomi Kurane, Tetsuro Matsunaga, Tomoaki Ida, Kazuko Sawada, Akira Nishimura, Masayuki Fukui, Masayuki Umemura, Masaaki Nakayama, Naoya Ohara, Sohkichi Matsumoto, et al. GRIM-19 is a target of mycobacterial Zn 2+ metalloprotease 1 and indispensable for NLRP3 inflammasome activation. The FASEB Journal. 2022. 36. 1
Ei'ichi Iizasa, Yasushi Chuma, Takayuki Uematsu, Mio Kubota, Hiroaki Kawaguchi, Masayuki Umemura, Kenji Toyonaga, Hideyasu Kiyohara, Ikuya Yano, Marco Colonna, et al. TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation. Nature communications. 2021. 12. 1. 2299-2299
M. Umemura, M. Fukui, T. Tamura, S. Nakae, Y. Iwakura, G. Matsuzaki. The involvement of IL-17A and IL-17F in chronic pulmonary mycobacterial infection. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 1250-1250
1986 - 1990 Kyushu University Graduate School of Medicine
1980 - 1986 Niigata University School of Medicine
Professional career (1):
Doctor of Medicine (Kyushu University)
Work history (6):
2023/05 - 現在 University of the Ryukyus Graduate School of Medicine Professor
2001/11 - 現在 University of teh Ryukyus Tropical Biosphere Research Center Molecular Microbiology Group Professor
1997/11 - 2001/10 Kyushu University Medical Institute of Bioregulation Department of Immunology Associate Professor
1995/10 - 1997/10 MRC Clinical Sciences Centre (London, UK) Tuberculosis and Related Infections Unit Visiting Researcher
1990/04 - 1995/09 Kyushu University Medical Institute of Bioregulation Department of Immunology Assistant Professor
- , University of the Ryukyus, Tropical Biosphere Research Center, Professor
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Committee career (3):
2009 - 現在 日本生体防御学会 理事
2003 - 現在 日本免疫学会 評議員
2015 - 2017 日本生体防御学会 会長
Association Membership(s) (4):
The Japanese Association for Developmental & Comparative Immunology
, JAPANESE SOCIETY FOR HOST DEFENSE RESEARCH
, JAPANESE SOCIETY FOR BACTERIOLOGY
, THE JAPANESE SOCIETY FOR IMMUNOLOGY