Rchr
J-GLOBAL ID:200901017348512020
Update date: Apr. 11, 2025 Yamaguchi Yoshihiro
ヤマグチ ヨシヒロ | Yamaguchi Yoshihiro
Affiliation and department: Job title:
Associate Professor
Other affiliations (1): Homepage URL (2): http://yamaguchi-labo.jp/
,
http://www.yamaguchi-labo.jp/ Research field (3):
Pharmaceuticals - analytical and physicochemistry
, Biochemistry
, Systems genomics
Research keywords (4):
酵素化学
, 安全学
, 希少遺伝子
, 化学物質管理
Research theme for competitive and other funds (20): - 2024 - 2027 Improving DNA normalization methods for obtaining low-copy double-stranded DNA fragments from metagenomes
- 2020 - 2025 非ベンゾジアゼピン系睡眠薬を標的とした抗体ファージライブラリーの構築と検出法開発
- 2017 - 2020 ラベルへの化学物質の危険有害性情報の付加に関する調査と開発及びその効果の測定
- 2017 - 2020 Physicochemical analysis of the effect of a single mutation on the active center and structure of metallo-beta-lactamase
- 2014 - 2017 Development of external-stimuli-responsive nanomaterials and evaluation of their compatibility with living cells
- 2014 - 2017 Physicochemical analysis of metallo-beta-lactamase with improved catalytic efficiency for cephem antibiotics
- 2012 - 2014 Development of fluorescent probes for metallo-beta-lactamase-producing Gram-negative bacteria
- 2012 - 2014 Physicochemical study and drug development for an unknown compound binding to metallo-beta-lactamase
- 2009 - 2011 Development of irreversible inhibitors forβ-lactam inactived enzyme, metallo-β-lactamase
- 2007 - 2008 細菌の多剤耐性化に関与するインテグラーゼの結晶構造と基質-酵素相互作用の解析
- 2006 - 2007 金属置換によるメタロ-β-ラクタマーゼの反応場の制御と基質-酵素複合体のX線結晶構造解析
- 2006 - 2007 In silicoと熱測定を併用した基質アナログ型メタロ-β-ラクタマーゼ阻害剤探索
- 2006 - 2007 Structure-based Design of Selective metallo-β-lactamase
- 2006 - 2007 ファージディスプレイ法によるメタロ-β-ラクタマーゼのペプチド阻害剤の網羅的探索
- 2005 - 2006 β-ラクタム剤耐性菌が産生するメタロ-β-ラクタマーゼの三次元構造に立脚した非可逆的阻害剤の開発
- 2004 - 2005 構造を利用したChryseobacterium indologenesが産生するメタロ-β-ラクタマーゼ(IND)阻害剤の開発
- 2004 - 2005 新興のβ-ラクタム耐性菌が産生するβ-ラクタマーゼのX線結晶構造解析とその阻害剤設計
- 2004 - 2005 Development of functional molecules capable of recognizing and cleaving the bulge structure in DNA by using an optical active dinuclear iron complex
- 2004 - 2005 Metallo-β-lactamase : Structural basis for substrate-specificity and rational design of the inhibitors
- 2002 - 2003 新興薬剤耐性菌が産生するメタロ-β-ラクタマーゼ(IMP-1)の加水分解機構解析による阻害剤の開発
Show all
Papers (44): -
Yoshimi Ichimaru, Koichi Kato, Yoshihiro Yamaguchi, Takayuki Sakamoto, Wanchun Jin, Masaaki Kurihara, Mikako Fujita, Masami Otsuka, Hiromasa Kurosaki. Design, Synthesis, and Characterization of 1-(Anthracen-9-ylmethyl)-1,5,9-triazacyclododecane (Ant-[12]aneN3) and Its DNA Photocleavage Activity. Chemical and Pharmaceutical Bulletin. 2025. 73. 2. 103-107
-
Yoshimi Ichimaru, Koichi Kato, Rina Nakatani, Risa Isomura, Kirara Sugiura, Yoshihiro Yamaguchi, Wanchun Jin, Hideki Mizutani, Masanori Imai, Masaaki Kurihara, et al. Structural Characterization of Zinc(II)/Cobalt(II) Complexes of Chiral N-(Anthracen-9-yl)methyl-N,N-bis(2-picolyl)amine and Evaluation of DNA Photocleavage Activity. Chemical and Pharmaceutical Bulletin. 2023. 71. 7. 545-551
-
Yoshimi Ichimaru, Koichi Kato, Kirara Sugiura, Sarina Ogawa, Wanchun Jin, Masaaki Kurihara, Yoshihiro Yamaguchi, Masanori Imai, Hiromasa Kurosaki. Aqua{μ-1,4-bis[(1,4,7,10-tetraazacyclododecan-1-yl)methyl]benzene}(nitrato-κO)dicopper(II) tris(nitrate) trihydrate. IUCrData. 2023. 8. 6
-
Yoshimi Ichimaru, Koichi Kato, Kirara Sugiura, Risa Isomura, Haruto Fujioka, Tohru Koike, Sayuri Fujii-Kishida, Masaaki Kurihara, Yoshihiro Yamaguchi, Wanchun Jin, et al. Artificial helix supramolecule by doubly p-xylyl bridged bis(ZnII-cyclen) (cyclen = 1,4,7,10-tetraazacyclododecane). Inorganic Chemistry Communications. 2023. 110782-110782
-
Yuya Uenosono, Ryohei Kawakami, Shogo Matsumoto, Yoshihiro Yamaguchi. Construction of an experimental study and addition of adapter sequences using HiDi DNA polymerase for improving DNA normalization methods relevant to novel gene discovery. Journal of Microbiological Methods. 2023. 204. 106631-106631
more... Patents (2): -
メタロ-β-ラクタマーゼ阻害剤
-
メタロ-β-ラクタマーゼ阻害剤
Books (2): - スタンダード薬学シリーズ2 物理系薬学 I.物質の物理的性質
東京化学同人 2011
- スタンダード薬学シリーズ2 物理系薬学 IV. 演習編
東京化学同人 2008
Education (4): - 2016 - 2019 Kumamoto University Graduate School of Social and Cultural Sciences Graduate School of Social and Cultural Sciences
- 2002 - 2003 Kumamoto University Kumamoto University Kumamoto University
- 2000 - 2002 Kumamoto University Kumamoto University Kumamoto University
- 1996 - 2000 Kumamoto University School of Pharmacy
Professional career (1): - Ph. D (Kumamoto University)
Work history (8): - 2025/04 - 現在 Kumamoto University Environmental Safety Center
- 2025/04 - 現在 Kumamoto University Faculty of Humanities and Social Sciences Associate Professor
- 2018/10 - 現在 Kumamoto University Graduate School of Science and Technology Associate Professor
- 2015/10 - 現在 株式会社ホリサカ・ラボラトリー 取締役(兼業)
- 2010/04 - 現在 Kumamoto University Graduate School of Science and Technology Associate Professor (concurrently)
- 2010/04 - 現在 Kumamoto University Faculty of Engineering Associate Professor (concurrently)
- 2006/04 - 2025/03 Kumamoto University Environmental Safety Center Associate Professor
- 2003/04 - 2006/03 Kumamoto University Graduate School of Medical and Pharmaceutical Sciences Assistant Professor
Show all
Awards (7): Association Membership(s) (4):
日本生物工学会
, 大学等環境安全協議会
, PROTEIN SCIENCE SOCIETY OF JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN
Return to Previous Page