Research theme for competitive and other funds (15):
2023 - 2026 Possibility of space reproduction in mammals
2019 - 2022 細胞非自律的に作用する遺伝子の網羅的同定法開発
2016 - 2019 絶滅動物の復活を目指した革新的技術開発
2015 - 2018 Establishment of a new disease model by congenital p53 hyperactive mutation
2015 - 2018 Analysis of individual chromosome dynamics in living embryo and establishment of next generation embryo manipulation technique by chromosome transfer
2011 - 2016 絶滅動物の細胞再生および有用遺伝子回収方法の確立
2008 - 2012 卵子による核の初期化機構の解明およびその促進方法の開発
2012 - 核移植による絶滅動物の復活方法の開発
2007 - 2009 Elucidation of the molecular mechanism underlying the enhancement of somatic-cell reprogramming by a histone deacetylase inhibitor, and its applications
2001 - 2002 Defining Critical Parameters of Mouse Cloning
1996 - 1998 核移植技術を用いた未分化配偶子および初期胚の受精卵構築能に関する研究
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Papers (273):
Mizuki Sakamoto, Aoi Ito, Sayaka Wakayama, Hiroyuki Sasaki, Teruhiko Wakayama, Takashi Ishiuchi. Detection of newly synthesized RNA reveals transcriptional reprogramming during ZGA and a role of Obox3 in totipotency acquisition. Cell reports. 2024. 43. 4. 114118-114118
Sayaka Wakayama, Yasuyuki Kikuchi, Mariko Soejima, Erika Hayashi, Natsuki Ushigome, Chiaki Yamazaki, Tomomi Suzuki, Toru Shimazu, Tohru Yamamori, Ikuko Osada, et al. Effect of microgravity on mammalian embryo development evaluated at the International Space Station. iScience. 2023. 26. 11. 108177-108177
Yasuyuki Kikuchi, Daiyu Ito, Sayaka Wakayama, Masatoshi Ooga, Teruhiko Wakayama. Time-lapse observation of mouse preimplantation embryos using a simple closed glass capillary method. Scientific reports. 2023. 13. 1. 19893-19893
Masatoshi Ooga, Yasuyuki Kikuchi, Daiyu Ito, Kousuke Kazama, Rei Inoue, Mizuki Sakamoto, Sayaka Wakayama, Teruhiko Wakayama. Aberrant histone methylation in mouse early preimplantation embryos derived from round spermatid injection. Biochemical and Biophysical Research Communications. 2023
Li Ly Yang, Daiyu Ito, Natsuki Ushigome, Sayaka Wakayama, Masatoshi Ooga, Teruhiko Wakayama. A novel, simplified method to prepare and preserve freeze-dried mouse sperm in plastic microtubes. The Journal of reproduction and development. 2023. 69. 4. 198-205
OOGA Masatoshi, INOUE Rei, WAKAYAMA Sayaka, KAMIMURA Satoshi, WAKAYAMA Teruhiko. Sperm-derived chromatin compaction effect is involved in the establishment of parental asymmetrically relaxed chromatin structure in mouse zygotes. The Journal of Reproduction and Development Supplement. 2021. 114. P-69-P-69