Rchr
J-GLOBAL ID:200901018769052202
Update date: Jan. 31, 2024
Hirota Akihiko
ヒロタ アキヒコ | Hirota Akihiko
Affiliation and department:
Research field (3):
Basic brain sciences
, Physiology
, Neuroscience - general
Research keywords (4):
膜電位感受性色素
, 光学的膜電位測定法
, Functional Development
, Optical recording method and its application
Research theme for competitive and other funds (34):
- 2013 - 2016 Development of two apparatuses used in the optical measurement: oscillation free mechanical stimulator and transparent electrode for electrical stimulation
- 2009 - 2011 Development of transparent electrode with curved surface for simultaneous detection of the electrocorticogram from inside of the optical recording area and/or for giving electro-stimulations to the area
- 2004 - 2006 膜電位の光学的測定の高精度化を目的とした高輝度かつ超高安定輝度を有する光源の開発
- 2000 - 2003 Improvement of the optical recording system for detecting membrane potential from multiple site using CCD video camera by installing a liquid crystal panel in the light path.
- 2000 - 2001 Construction and analyzing of functional map in cerebral cortex using a newly developed dual wavelength measurement system for optically monitoring membrane potential from multiple site
- 1997 - 1999 Development a new dual wavelength measurement optical recording system of membrane potential from multiple site simultaneously using urtra-high luminance light emitting diode for the light source
- 1996 - 1998 Functional study of the olfactory sensory signal transduction mechanism using the optic fiber system for optically monitoring membrane potential.
- 1997 - 1997 生体染色法の開発による難水溶性色素の再評価を軸とした高性能膜電位感受性色素の探索
- 1995 - 1997 Optical Analysis of Distributed Processing in Neural Systems
- 1996 - 1996 光散乱を指標にした体積測定法による血球膜の粘弾性の解析とその適用
- 1994 - 1996 Development of three-dimensional optical recording methods for neural activity in the central nervous system.
- 1995 - 1995 房質回帰性頻脈誘発性の心房細・粗動の研究-光学的多チャネル計測による解析-
- 1993 - 1995 Optical recording system for monitoring neural activity in deep region of the brain.
- 1994 - 1994 膜電位感受性色素とCa指示薬の二重染色による交感神経節シナプス動態の光学的解析
- 1994 - 1994 波長スペクトルの異なる膜電位感受性色素の二重染色による興奮旋回の光学的三次元解析
- 1993 - 1994 Searches for new voltage-sensitive dyes
- 1993 - 1993 カーボシアニン系蛍光色素による発生初期胚脳幹における脳神経投射パターン形成の追跡
- 1991 - 1993 Developmental research of a new 1020-site optical recording system for monitoring neural activity of central nervous system.
- 1992 - 1992 自律分散システムとしてみた心臓ペースメーカー領域の機能的構成に関する研究
- 1991 - 1991 自律分散システムとしてみた心臓ペ-スメ-カ-領域の機能的構成に関する研究
- 1991 - 1991 膜電位感受性色素ーCa指示薬ー光散乱の組合せによる脳シナップス過程の光学的測定
- 1989 - 1991 Optical mapping of functional organization in the early embryonic brain stem using multiple-site recording of neural activity together with voltage-sensitive dyes.
- 1990 - 1990 自律分散システムとしてみた心臓ペ-スメ-カ-領域の機能的構成に関する研究
- 1990 - 1990 膜電位感受性色素ーCa指示薬一光散乱の組合せによる脳シナプス過程の光学的追跡
- 1989 - 1989 膜電位感受性色素-Ca指示薬-光散乱の組み合せによる脳シナプス過程の光学的測定
- 1989 - 1989 膜電位感受性色素を用いた光学的測定によるショウジョウバエ神経活動のパタ-ン解析
- 1989 - 1989 新しいCa指示薬を用いた骨格筋細胞内Ca濃度変化とその制御因子の追跡
- 1986 - 1988 Developmental Study on a Simultaneous Processing System for Microphotometry and Video Image of Dynamic Cell Function.
- 1986 - 1986 培養初期胚血管網における収縮能および血管粘弾性の形成と発達の光学的研究
- 1986 - 1986 中枢神経系ニューロン活動の光学的リアルタイムマッピング
- 1986 - 1986 細胞膜電位活動の光学的リアルタイム多チャンネル測定システム
- 1978 - 大脳皮質の自発興奮のマッピング(光学的多部位同時測定法を用いた方法)
- 1978 - 膜電位の光学的測定法の開発とその応用
- 1978 - Develop a new optical recording system for membrane potential using voltage sensitive dyes and its application
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Papers (61):
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Hama N, Kawai M, Ito S, Hirota A. Optical analysis of acute changes after peripheral nerve injury in spatio-temporal pattern of neural response to forelimb stimulation in rat somatosensory cortex. Neuroscience. 2020. 448. 85-93
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Hama, N, Kawai, M, Ito, S, Yoshida, Y, Fujita, Y, Hirota, A. Concave-shaped transparent electrode to simultaneously monitor electrical activity from multiple sites within the optical sampling area of the intact rat cerebral cortex. Journal of Physiological Sciences. 2019. 69. 3. 543-551
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Hama, N, Kawai, M, Ito, S, Hirota, A. Optical study of interactions among propagation waves of neural excitation in the rat somatosensory cortex evoked by forelimb and hindlimb stimuli. Journal of Neurophysiology. 2018. 119. 1934-1946
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Hama, N, Ito, S, Hirota, A. Optical imaging of the propagation patterns of neural responses in the rat sensory cortex: Comparison under two different anesthetic conditions. Neuroscience. 2015. 284. 125-133
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Kawai, M, Hama, N, Ito, S, Hirota, A. Improvement of the optical imaging technique for intact rat brain using a plano-concave lens. Journal of Physiological Sciences. 2014. 64. 445-449
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MISC (27):
Patents (1):
Books (7):
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"A novel GABA response identified optically in the nucleus of the tractus solitarius of the chick embroyo"
GABA; Receptors, Transporters and Metabolism. Ed. by Tanaka, C. and Bowery, N.G., Birkhauser Verlag (Basel/Switzerland) 1996
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細胞膜電位活動の光学的マルチサイト同時計測システムの開発.
中谷電子計測技術振興財団十周年記念誌 1995
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"Optical mapping of spontaneous electrical activity and functional organzation of pacemaking area in the early embryonic chick heart"
Progress in Biomedical Optics; Proceeding of clinical applications of modern imaging technology II. Ed. by Katzir, A. The Society of Photo-Optical Instrumentation Engineers 1994
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"Optical monitoring of postsynaptic potential in the early embryonic avian brain stem using a voltage-sensitive dye"
Fluorescence Spectroscopy, Ed. by Wolfbesis, O.S. Springer(Berlin) 1992
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赤血球の浸透圧的挙動と溶血法による膜透過に関する実験.
日本生理学会編、新・生理学実習書、第2版、第1章. 南江堂(東京) 1991
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Lectures and oral presentations (13):
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Relationship between the stimulus intensity and the spatio-temporal patterns of the evoked activity in the rat sensorimotor cortex using improved optical recording system
(NEUROSCIENCE RESEARCH 2011)
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Single sweep analysis on the long-duration continuous multiple-site recording of neural activity obtained optically from in vivo rat somatosensory cortex stained with a voltage-sensitive dye
(JOURNAL OF PHYSIOLOGICAL SCIENCES 2010)
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Diversity in the spatio-temporal pattern of spontaneous neural activities in the rat sensorimotor cortex detected with the multiple-site optical recording system with high signal-to-noise ratio
(NEUROSCIENCE RESEARCH 2010)
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OPTICAL IMAGING OF THE SPONTANEOUS NEURAL ACTIVITY IN CEREBRAL CORTEX IN VIVO USING A TRANSPARENT ELECTRODE FOR ANALYZING ON A SINGLE SWEEP
(JOURNAL OF PHYSIOLOGICAL SCIENCES 2009)
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Analysis of spontaneous activity in the rat sensorimotor cortex recorded optically with voltage-sensitive dye
(NEUROSCIENCE RESEARCH 2009)
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Education (3):
- 1978 - 1982 Tokyo Medical and Dental University Medical graduate course Physiology
- 1972 - 1978 Yamaguchi University School of Medicine Medicine course
- 1967 - 1970 Kawagoe senior high school
Professional career (1):
- Medical Doctor (Tokyo Medical and Dental University)
Work history (7):
- 2017/04 - 現在 Shimane University Emeritus Professor
- 2003/10 - 2017/03 Shimane University Faculty of Medicine Professor
- 1995/09 - 2003/10 Shimane Medical University Faculty of Medicine professor
- 1990/04 - 1995/08 Tokyo Medical and Dental University Faculty of Medicine Assistant professor
- 1988/12 - 1990/03 Tokyo Medical and Dental University Faculty of Medicine Lectureship
- 1982/04 - 1988/11 Tokyo Medical and Dental University Faculty of Medicine Assistant Researcher
- 1986/10 - 1988/09 Yale University School of Medicine Department of Physiology Associate Research Scientist
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Committee career (2):
- 1985 - 日本生理学会 評議員
- 1985 - The Physiological Society of Japan Councilor
Awards (2):
- 1997 - 日本生理学会 入澤賞
- 1997 - The Hiroshi Irisawa Memorial JJP Award
Association Membership(s) (3):
日本生理学会
, Biophysical Society
, The Physiological Society of Japan
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