Rchr

J-GLOBAL ID：200901019174016632 Update date: Nov. 18, 2024

Egusa Hiroshi

エグサヒロシ | Egusa Hiroshi

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Tohoku University Hospital General Vice-Director, Tohoku University Hospital

Homepage URL (2)： http://crbr.dent.tohoku.ac.jp/index.html , http://crbr.dent.tohoku.ac.jp/

Research field (3)： Regenerative dentistry and dental engineering , Prosthodontics , Molecular biology

Research keywords (7)：バイオマテリアル , 口腔インプラント学 , 歯科補綴学 , 再生医療 , 院内感染防止対策 , デジタル歯科 , 骨生物学

Research theme for competitive and other funds (58)：

2024 - 2027 新たな細胞死「フェロトーシス」の制御に着目した新規顎骨増生技術の開発
2022 - 2026 細胞膜模倣バイオマテリアルの創製と迅速骨再生への応用
2022 - 2025 新規ニッケル結合性T細胞を基軸としたニッケルアレルギー病態形成機構の解明
2022 - 2025 自然治癒力と骨質を高める細胞由来骨模倣材料による顎骨再生の新機軸
2021 - 2024 AI機械学習を基盤とした支台歯形成技能評価システムの自律化

2021 - 2024 Development of a vascularized organoids transplantation technology for next-generation regenrative medicine

2020 - 2023 骨小腔-骨細管系ネットワークの制御を基盤とした即時負荷インプラントの開発

2020 - 2023 New innovation of jaw bone reconstruction using octacalciumphosphate/collagen composite and iPS cells

2020 - 2023 バイオ3Dプリンティング技術を応用した歯周組織再生型インプラントの開発

2020 - 2023 疾患由来iPS細胞レジストリとPLAP-1を基軸とした侵襲性歯周炎の分子病態解明

2020 - 2022 iPS細胞を原材料とした骨形成誘導補填材の開発

2019 - 2022 Challenge of controling tooth root length by HDAC3 inhibition of dental mesenchym

2019 - 2022 Development of Bone Organoid Models Towards the Precision Prosthodontics

2018 - 2021 Analysis of bone metabolism for predictable extra-vertical bone augmentation

2018 - 2021 Development of a machine learning-based automatic evaluation system for clinical skills in tooth preparation

2017 - 2021 Elucidation of organ determination mechanism in epithelial / endothelial invaginated tissue

2018 - 2020 Self-organization of iPS cells using environmental factors in the tooth development

2017 - 2020 Prospective clinical study of monolithic zirconia crowns-Following morphology and function for long-term prognosis-

2017 - 2020 Development of genetic risk prediction method for tailor-made treatment for chronic orofacial pain

2017 - 2020 Induction of periodontal ligaments on titanium implants mimicking nanotopography of cementum

2017 - 2019 Development of bone regeneration method for self-assembly of size-controlled iPS cell spheroid

2017 - 2019 Exploring nano-surface topography of dental implants to regulate osteoimmunology

2017 - 2019 A study of bioactive materials used for bone filling

2016 - 2019 Molecular biological search for non-infectiously induced peri-implant bone resorption

2016 - 2019 Development of iPS cell-based tooth regeneration techniques by a transposon-based gene delivery system

2016 - 2018 Investigation of human iPS cell derived 3D bone like tissue using hypoxic culture

2016 - 2018 Establisment of regenerative techique for jaw bone using MSCs spheroids cultureing with floating condition.

2016 - 2018 Development of a method for the endochondral alveolar bone tissue engineering using iPS cells

2015 - 2018 The surface morphology of titanium plate could change macrophage activity.

2015 - 2018 Fracture factors of full zirconia ceramic restoration with mechanical analysis in prospective clinical study.

2015 - 2018 Epiprofin regulation in cell proliferation and differentiation in tooth development

2015 - 2017 Development of jaw bone resorption suppression technique targeting glutamate transport protein PICK1

2015 - 2017 Vertical Bone Augmentation Using iPS Cell Constructs with CAD/CAM Dome

2014 - 2017 Development of novel therapeutics for the treatment of marfan syndrome using iPS technology

2014 - 2017 Regulation and determination of organ derived from invaginated epithelium

2013 - 2017 Development of diagnostic technology for establishment of tailor-made prosthodontic treatments

2014 - 2016 Fabrication of bone graft materials using iPS cells

2013 - 2016 Establishment of iPS cell-based bone tissue engineering using small molecule compounds

2013 - 2016 Development of technologies for next-generation regenerative therapies

2013 - 2015 Development of the new method to control the resorption of alveolar bone, targeting receptor acting on bone - nervous system

2012 - 2014 Development of the iPS cell-based diagnostic technology for dental treatments

2011 - 2012 multi-analysis of bone-implant interface using X-ray analysis and electron tomography

2011 - 2012 Development of virus-free generation and xeno-free culture of human gingiva-derived iPS cells

2010 - 2012 Technology creation of iPS cell-based alveolar bone regenerationusing the gingiva as a cell source

2010 - 2012 Development of bone resorption inhibitors/drugs targeting signaling molecule PICK1

2010 - 2012 Development of cell-based screening system for identifying osteogenesis-targeting compounds

2010 - 2011 Analysis of bone regeneration using small-molecule harmine and Id2-knockout mice

2009 - 2010 酸化チタンナノチューブ構造制御による新しい生体活性型インプラントの開発

2007 - 2009 Induction of Bone Regeneration by Controlled Release of Osteogenesis/Angiogenesis Factors from Titanium Implants

2007 - 2008 咀嚼筋・舌組織の再生に向けた筋系細胞分化促進技術の開発

2007 - 2008 5-HTT遺伝子型および認知行動療法を用いた難治性TMD患者のスクリーニング

2006 - 2008 Effects of Mechanical Stress on Oral Mucosa and Its Relation to Osteo-Immunology in Alveolar Bone

2005 - 2006 合成ペプチドを用いた骨/血管新生誘導型インプラント材料の開発

2004 - 2006 Study on Mechanisms of Gene Silencing during Adult Stem Cell Differentiation

義歯性口内炎・口腔カンジダ症の新規予防法および治療法の開発

歯槽骨の再生医療に向けた顎堤のバイオサイエンスの確立

歯肉組織を用いたiPS細胞の樹立・分化機構に関する研究

Differentiation mechanism of adult stem cell

Show all

Papers (202)：

Tomonari Kajita, Kenji Kikuchi, Hiromitsu Morishima, Jun Watanabe, Yoko Iwamatsu-Kobayashi, Hiroyasu Kanetaka, Wataru Yashiro, Kensuke Yamauchi, Hiroshi Egusa. Reduction of aerosol and droplet dispersions using intraoral and extraoral vacuums for dental treatments with face-up, diagonal and upright positions. BMC Oral Health. 2024. 24. 1
Ohori-Morita Y., Ashry A., NiibeK., Egusa H. Current perspectives on the dynamic culture of mesenchymal stromal/stem cell spheroids. Stem Cells Transl Med. 2024. accepted
Suwittayarak R., Nowwarote N., Kornsuthisopon C., Sukarawan W., Foster BL, Egusa H., Osathanon T. Effects of inorganic phosphate on stem cells isolated from human exfoliated deciduous teeth. Sci Rep. 2024. 14. 1. 24282
Kunihiro Fushimi, Jun Watanabe, Masahiro Yamada, Jumpei Washio, Nobuhiro Takahashi, Hiroshi Egusa. Effects of flushing of dental waterlines in portable dental units on water quality management. Journal of Dental Sciences. 2024
Yukari Shiwaku, Hiroko Okawa, Ikuro Suzuki, Susumu Sakai, Hiroshi Egusa, Osamu Suzuki. Induced pluripotent stem cell-derived neural stem cells promote bone formation in mice with calvarial defects. Acta Biomaterialia. 2024. 188. 93-102

ｍore...

MISC (126)：

遠藤弥生, 勝田悠介, 互野亮, 尾崎茜, 山田将博, 江草宏, 董哲耀, 熊澤逸夫. 歯を切削する技能を可視化/スコア化した評価システムの開発. 生体医歯工学共同研究拠点成果報告書. 2024. 2023年度. 185-185
渡辺隼, 小林洋子, 江草宏. 超音波スケーラーによる飛沫エアロゾルの可視化と吸引装置による拡散抑制効果. 日本口腔内科学会雑誌. 2023. 29. 2. 89-89
伏見国拡, 渡辺隼, 山田将博, 江草宏. 歯科訪問診療用ポータブルユニットの水質管理に対する影響要因の検討. 日本口腔内科学会雑誌. 2023. 29. 2. 90-90
小林洋子, 倉内美智子, 渡辺隼, 草間太郎, 菅原寛子, 西條文人, 田畑雅央, 飯久保正弘, 杉浦剛, 江草宏. 東北大学病院歯科部門における過去16年間の誤飲・誤嚥インシデント. 医療の質・安全学会誌. 2023. 18. Suppl. 352-352
鹿内陽樹, 山田将博, 大竹孝幸, 渡辺隼, 江草宏. ミクロ/ナノ階層的表面改質によるチタンインプラントの骨結合強さの増強. 日本補綴歯科学会誌. 2023. 15. 東北・北海道支部学術大会特別号. 37-37

ｍore...

Patents (15)：

Method for maintaining undifferentiation potency of mesenchymal stem cell employing shaking suspension culture
口腔粘膜由来細胞を利用した誘導多能性幹細胞(iPS細胞)の効率的な製造方法
口腔粘膜由来細胞を利用した誘導多能性幹細胞(iPS細胞)の効率的な製造方法
破骨細胞が関与する疾患の予防剤又は治療剤
Mesenchymal cell proliferation promoter and skeletal system biomaterial

ｍore...

Books (12)：

よくわかる口腔インプラント学第4版
医歯薬出版 2023
クラウンブリッジ補綴学第6版
医歯薬出版 2021
Molecular Players in iPSC Technology, 1st Edition
Ed: Birbrair A, Elsevier 2021
院内感染防止対策のスタンダード
デンタルダイアモンド社 2020
関節・軟骨の再生医療
シーエムシー出版 2019

ｍore...

Lectures and oral presentations (64)：

In vitro bone tissue fabrication by using iPS cells
(The 96th IADR General Session 2018)
小臼歯CAD/CAM冠の臨床評価から考える大臼歯CAD/CAM冠の勘どころ
(第127回日本補綴歯科学会学術大会 2018)
インプラント臨床における再生医療の現状と挑戦
(第37回日本口腔インプラント学会近畿・北陸支部学術大会 2017)
iPS cell-based strategies in bone tissue engineering
(第65回 JADR学術大会国際シンポジウム “Advances in iPS cell research and its application to dental medicine” 2017)
Emerging approaches for “regenerative prosthodontics”
(2017)

ｍore...

Education (2)：

1998 - 2002 Hiroshima University Graduate School PhD: Division of Dental Science
1992 - 1998 Hiroshima University DDS: Faculty of Dentistry

Professional career (1)：

DDS, PhD (Hiroshima University)

Work history (25)：

2024/06 - 現在東北大学特定認定再生医療等委員会副委員長
2024/06 - 現在東北大学認定再生医療等委員会副委員長
2023/04 - 現在 Tokyo Institute of Technology Institute of Innovative Research Visiting Professor
2023/04 - 現在 Tohoku University Graduate School of Dentistry Joint Research Department of Next-Generation Dental Material Engineering Professor
2022/04 - 現在東北大学教育研究評議会評議員

2022/04 - 現在 Tohoku University Hospital General Vice-Director

2022/04 - 現在 Tohoku University Hospital Dental Safety and System Management Chair

2022/04 - 現在 Head of Dental Division, Tohoku University Hospital

2021/04 - 現在 Tohoku University Hospital Dental Laboratory Unit Chief

2020/04 - 現在 Tohoku University Graduate School of Dentistry Center for Advanced Stem Cell and Regenerative Research Director

2016/04 - 現在 Hiroshima University Faculty of Dentistry Visiting Professor

2015/04 - 現在 Showa University School of Dentistry Visiting Professor

2014/04 - 現在 Tohoku University Hospital Fixed Prosthodontics Chair

2014/04 - 現在 Tohoku University Graduate School of Dentistry Division of Molecular and Regenerative Prosthodontics Professor and Chair

2018/04 - 2023/03 Tohoku University Provost Staff

2018/04 - 2023/03 Tohoku University Graduate School of Dentistry Liaison Center for Innovative Dentistry Director Director

2021/04 - 2022/03 Tohoku University Hospital Dental Hygiene Unit Chief

2018/04 - 2022/03 Tohoku University Hospital Vice-Director

2018/04 - 2021/03 Tohoku University Hospital Infection Control Unit (Dentistry) Chair

2007/04 - 2014/03 Osaka University Graduate School of Dentistry

2004/04 - 2007/03 Osaka University Graduate School of Dentistry

2002/06 - 2004/05 University of California, Los Angels (UCLA), The Jane and Jerry Weintraub Center for Reconstructive Biotechnology Visiting Scholar (Postdoctoral Research Fellow)

2002/04 - 2004/03 Japan Society for the Promotion of Science (JSPS) Japanese Government Special Postdoctoral Research Fellow

2001/05 - 2002/03 Hiroshima University Graduate School of Dental Science

1999/01 - 1999/07 University of Hong Kong, Department of Oral Microbiology Technical Assistant

Show all

Committee career (36)：

2024/07 - 現在日本歯科専門医機構共通研修企画実施委員会委員
2024/06 - 現在 Japanese Stomatological Society Director
2024/05 - 現在 Oral Frontier Science Mentor
2024/04 - 現在 The Japanese Society for Dental Materials and Devices Director
2024/04 - 現在 Japanese Society for Biomaterials Director

Show all

Awards (18)：

2023/05 - Japan Prosthodontic Society JPR Best Paper Award (Original Article Category)
2020/06 - Japan Prosthodontic Society JPR Best Paper Award(for Review Article)
2019/05 - Japan Prosthodontic Society Distinguished Paper Award
2014/10 - 日本学術振興会科研費審査委員表彰
2013/08 - Osaka University Distinguished Achievement and Contributions Award

Show all

Association Membership(s) (11)：

THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , THE JAPANESE SOCIETY FOR BIOMATERIALS , International College of Prosthodontists , JAPANESE DENTAL EDUCATION ASSOCIATION , JAPANESE SOCIRTY OF ORAL IMPLANTOLOGY , 日本歯科理工学会 , 日本骨代謝学会 , 歯科基礎医学会 , 日本補綴歯科学会 , International Association for Dental Research(IADR) , 日本口腔感染症学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page