Rchr
J-GLOBAL ID：200901019809933890
Update date: Nov. 18, 2024
Tobe Kazuyuki
トベ カズユキ | Tobe Kazuyuki
Affiliation and department：
Job title：
Distinguished Research Proefssor
Homepage URL (1)：
http://www.med.u-toyama.ac.jp/medicin1/
Research field (4)：
Cardiology
, Orthopedics
, Laboratory animal science
, Metabolism and endocrinology
Research keywords (31)：
インスリン抵抗性
, アディポネクチン
, PPARγ
, 肥満
, IRS-2
, インスリン受容体
, 脂肪細胞
, IRS-1
, レプチン
, 動脈硬化
, PI3キナーゼ
, 発生工学
, チアゾリジン誘導体
, 高脂肪食
, インスリン
, IRS-3
, 脂肪肝
, 膵β細胞
, マクロファージ
, ras
, 脂肪組織
, ノックアウトマウス
, レプチン抵抗性
, トランスジェニックマウス
, IRS-1欠損マウス
, 代謝症候群
, チロシンキナーゼ
, 肥満インスリン抵抗性
, インスリン受容体基質
, インスリン作用
, 糖尿病
Research theme for competitive and other funds (1)：
- 糖尿病の発症機序の解明 インスリン作用、インスリン抵抗性の分子機構
Papers (52)：
-
Yoshiyuki Watanabe, Shiho Fujisaka, Yoshitomo Morinaga, Shiro Watanabe, Allah Nawaz, Hideki Hatta, Tomonobu Kado, Ayumi Nishimura, Muhammad Bilal, Muhammad Rahil Aslam, et al. Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice. Molecular Metabolism. 2023. 77. 101797-101797
-
Haruka Kishi, Isao Usui, Teruo Jojima, Shiho Fujisaka, Sho Wakamatsu, Yuiko Mizunuma-Inoue, Takafumi Niitani, Shintaro Sakurai, Toshie Iijima, Takuya Tomaru, et al. Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice. International journal of molecular sciences. 2022. 23. 23
-
Allah Nawaz, Muhammad Bilal, Shiho Fujisaka, Tomonobu Kado, Muhammad Rahil Aslam, Saeed Ahmed, Keisuke Okabe, Yoshiko Igarashi, Yoshiyuki Watanabe, Takahide Kuwano, et al. Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration. Nature Communications. 2022. 13. 1
-
Takashi Kadowaki, Joakim Isendahl, Usman Khalid, Sang Yeoup Lee, Tomoyuki Nishida, Wataru Ogawa, Kazuyuki Tobe, Toshimasa Yamauchi, Soo Lim. Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial. The Lancet Diabetes & Endocrinology. 2022. 10. 3. 193-206
-
Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Muhammad Rahil Aslam, Yoshiko Igarashi, Ayumi Nishimura, Yoshiyuki Watanabe, Takahide Kuwano, Jianhui Liu, Hiroyuki Miwa, et al. Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet. Molecular Metabolism. 2021. 54. 101328-101328
ｍore...
MISC (26)：
-
Hisae Honoki, Kunimasa Yagi, Kenta Kambara, Daisuke Chujo, Masataka Shikata, Asako Enkaku, Akiko Takikawa-Nishida, Jianhui Liu, Shiho Fujisaka, Kazuyuki Tobe. Anti-programmed death ligand 1 therapy-induced type 1 diabetes presenting with multiple islet-related autoantibodies. JOURNAL OF DIABETES INVESTIGATION. 2020. 11. 1. 253-254
-
Keisuke Okabe, Allah Nawaz, Shiho Fujisaka, Kunimasa Yagi, Tomonobu Kado, Isao Usui, Takashi Nakagawa, Kazuyuki Tobe. Nampt Deletion Changes Metabolism in Adipose Tissue and Prevents Diet-Induced Obesity. DIABETES. 2019. 68
-
Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe, Takashi Nakagawa. Implications of altered NAD metabolism in metabolic disorders. Journal of Biomedical Science. 2019. 26. 1
-
Akiko Takikawa, Isao Usui, Qun Zhang, Keisuke Okabe, Tomonobu Kado, Allah Nawaz, Shiho Fujisaka, Takashi Nakagawa, Koichi Tsuneyama, Kazuyuki Tobe. Myeloid Cell-specific HIF-1 alpha Deletion Decreases the Number of Liver Tumors in High Fat-fed Mice. DIABETES. 2016. 65. A503-A504
-
Manabu Ishiki, Yasuhiro Nishida, Akiko Takikawa, Yukiko Koshimizu, Minoru Iwata, Isao Usui, Kazuyuki Tobe. Astaxanthin, a Strong Antioxidant, Ameliorated Glucose Metabolism in Obese Mouse Through Various Mechanisms. DIABETES. 2014. 63. A503-A504
ｍore...
Education (1)：
- - 1983 The University of Tokyo
Work history (1)：
- 2009 - 2011 University of Toyama
Association Membership(s) (8)：
日本肥満学会
, 日本動脈硬化学会
, 日本病態栄養学会
, 米国糖尿病学会
, 日本内科学会
, 日本糖尿病合併症学会
, 日本内分泌学会
, 日本糖尿病学会
