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J-GLOBAL ID：200901020267888255 Update date: Mar. 21, 2025

Minamino Naoto

ミナミノナオト | Minamino Naoto

Affiliation and department：
Job title： Visiting Research Fellow
Homepage URL (1)： http://www.ncvc.go.jp/omics/

Research field (3)： Medical biochemistry , Functional biochemistry , Molecular biochemistry

Research keywords (12)：プロテオーム , 微量配列解析 , データベース , 循環調節因子 , ホルモン , 生理活性ペプチド , Proteome , Microsequence Analysis , Database , Circulation Regulatory Factor , Hormone , Biologically Active Peptide

Research theme for competitive and other funds (8)：

2010 - 2014 多層的疾患オミックス解析における、プロテオーム情報に基づく創薬標的の網羅的探索を目指した研究
2008 - 2012 疾患関連創薬バイオマーカー探索研究
2008 - 2012 Systematic survey for disease-related biomarkers for drug discovery, diagnosis and prognosis
2005 - 2009 循環器関連タンパク質・ペプチドをターゲットとした創薬による画期的な予防、治療法の開発
2006 - 2008 ペプチドーム解析に基づく組織特異的なプロセシング予測法の開発

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Papers (340)：

Toshio Nishikimi, Yasuaki Nakagawa, Shoichi Miyamoto, Takahiko Kanamori, Hideaki Inazumi, Hiromu Yanagisawa, Kenji Moriuchi, Hideaki Kinoshita, Yusuke Tamamura, Hiroyuki Takahama, et al. Responses of B-type natriuretic peptide (BNP), mature BNP and proBNP to sacubitril/valsartan differs between responders and non-responders. Open heart. 2025. 12. 1
Marina Arai, Yasuhide Asaumi, Satoshi Honda, Soshiro Ogata, Eri Kiyoshige, Kazuhiro Nakao, Hiroyuki Miura, Yoshiaki Morita, Takahiro Nakashima, Kota Murai, et al. Association between left ventricular reverse remodelling and the B-type natriuretic peptide-cGMP cascade after anterior acute myocardial infarction. Open heart. 2025. 12. 1
新井真理奈, 浅海泰栄, 本田怜史, 三浦弘之, 尾形宗士郎, 邑井洸太, 岩井雄大, 澤田賢一郎, 真玉英生, 藤野雅史, et al. B-Type Natriuretic Peptide Bioactivity and Its Influence on Left Ventricular Reverse Remodeling after Acute Myocardial Infarction: Insights from Prospective Study(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ003-3
Weidong Zhang, Ayako Miura, Md Moin Abu Saleh, Koichiro Shimizu, Yuichiro Mita, Ryota Tanida, Satoshi Hirako, Seiji Shioda, Valery Gmyr, Julie Kerr-Conte, et al. The NERP-4-SNAT2 axis regulates pancreatic β-cell maintenance and function. Nature communications. 2023. 14. 1. 8158-8158
Nobuhiko Ueda, Naoya Kataoka, Yuichiro Miyazaki, Keiko Shimamoto, Akinori Wakamiya, Kenzaburo Nakajima, Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Kenichiro Yamagata, et al. N-terminal pro atrial natriuretic peptide as a prognostic marker of cardiac resynchronization therapy recipients. International journal of cardiology. Heart & vasculature. 2023. 49. 101282-101282

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MISC (193)：

高濱博幸, 南野直人. 心房性ナトリウム利尿ペプチド(ANP)の分子形態について : ARNI時代における高精度ANP測定の臨床的意義-Molecular forms of atrial natriuretic peptides. 循環器内科 = Cardioangiology / 循環器内科編集委員会編. 2021. 89. 4. 490-496
高濱博幸, 高潮征爾, 錦見俊雄, 林友鴻, 中川靖章, 天野雅史, 濱谷康弘, 岡田厚, 天木誠, 長谷川拓也, et al. 急性心不全患者において入院時のproANP値は臨床転帰の予測能が優れている proBNPとBNPとの比較(Superior Predictability of proANP Level on Admission for Clinical Outcomes in Acute Heart Failure Patients: Comparison with proBNP and BNP). 日本循環器学会学術集会抄録集. 2019. 83回. PJ034-6
高濱博幸, 高潮征爾, 錦見俊雄, 林友鴻, 中川靖章, 天野雅史, 濱谷康弘, 岡田厚, 天木誠, 長谷川拓也, et al. Superior Predictability of proANP Level on Admission for Clinical Outcomes in Acute Heart Failure Patients: Comparison with proBNP and BNP(和訳中). 日本循環器学会学術集会抄録集. 2019. 83回. PJ034-6
Nagai-Okatani Chiaki, Nishigori Mitsuhiro, Sato Takashi, Minamino Naoto, Kaji Hiroyuki, Kuno Atsushi. Identification of Wisteria Floribunda Agglutinin as a Specific Lectin for Detection of Cardiac Fibrosis in a Dilated Cardiomyopathy Mouse Model Using Lectin Microarray-Based Glycomic Analysis. 日本循環器学会学術集会抄録集. 2019. 83回. TP20-3
森慶太, 石井輝, 半田貴也, 生島昭恵, 望月直樹, 南野直人, 柳田素子, 向山政志, 横井秀基. 高齢者慢性腎臓病における心保護・骨延長因子オステオクリンの低下. 日本内科学会雑誌. 2019. 108. Suppl. 192-192

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Patents (1)：

cAMPの産生活性を有する新規ペプチド

Books (1)：

ペプチドと創薬
メディカルドゥ 2007 ISBN:9784944157389

Education (2)：

- 1976 Osaka University School of Science Department of Chemistry
- 1976 Osaka University Faculty of Science Department of Chemistry

Professional career (1)：

Ph.D. (Osaka University)

Work history (4)：

2022/04 - 現在 National Cerebral and Cardiovascular Center Department of Cardiovascular Medicine, Division of Nephrology and Hypertension, and Department of Cardiac Physiology Visiting Research Fellow
2020/04 - 現在蛋白質研究奨励会 Research Fellow
2019/04 - 現在 National Cerebral and Cardiovascular Center Omics Research Center, Open Innovation Center Research Director
2015/04 - 2019/03 National Cerebral and Cardiovascular Center Omics Research Center Director

Committee career (10)：

2008 - 2010 国際神経ペプチド学会日本支部支部長
2002 - 日本生化学会評議員
2002 - 日本ペプチド学会評議員・理事
2002 - The Japanese Biochemical Society (Member of the Board)
2002 - The Japanese Peptide Society (Member of the Board)

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Awards (4)：

2015/11 - The Japan Peptide Society Award 2015
2015/11 - 日本ペプチド学会賞(平成27年度)
1989 - 日本生化学会奨励賞(平成元年度)
1989 - The Young Investigator Award, The Japanese Biochemical Society (1989)

Association Membership(s) (12)：

国際神経ペプチド学会日本支部 , 日本心血管内分泌代謝学会 , 米国内分泌学会 , 日本内分泌学会 , 日本蛋白質科学会 , 日本生化学会 , 日本ペプチド学会 , Protein Science Society of Japan , The Japan Endocrine Society , The Endocrine Society (U.S.A) , The Japanese Biochemical Society , The Japanese Peptide Society

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