Research theme for competitive and other funds (38):
2024 - 2028 陽子線 FLASH 照射による難治性脳腫瘍根絶へ向けた開発
2024 - 2027 Sleep regulation by protein phosphorylation in Drosophila
2021 - 2024 New Aspects of Sleep-Wake Regulation of Drosophila
2018 - 2021 Sleep-wake regulation mechanism in Drosophila
2016 - 2019 Development of effective curative for chronic pain based on the separation of sensory-discriminative and affective-motivational components of pain recognition in animal and human.
2013 - 2018 Molecular and neural bases of memory dynamism in Drosophila
2014 - 2017 Identification of novel bioactive peptides to modulate feeding behavior in insects.
2013 - 2016 Analysis of sleep-arousal regulation in Drosophila melanogaster
2010 - 2012 Sleep and arousal regulation in Drosophila melanogaster
2008 - 2010 Structuration of bioethical arguments in Japan based on the reexamination of the basic moral concepts
2005 - 2006 Molecular Analysis of the sleep and arousal regulations in the fruit fly, Drosophila melanogater
2005 - 2005 神経細胞初期培養系を用いた概日周期・覚醒睡眠制御機構の解析
2003 - 2004 Molecular Analysis of the sleep and arousal regulations and their relationship to the circadian rhythm using fruit fly, Drosophila melanogaster.
2003 - 2004 ES細胞から内胚葉系幹細胞への分化制御
2003 - 2003 ES細胞からの内胚葉細胞系譜制御遺伝子プロファイリング解析
1998 - 2001 ノックアウトマウスを使ったcPLA2の機能解析と新規PLA2の検索
1999 - 2000 Specific roles of Src family kinases in inflammatory signaling pathways
1998 - 1999 FUNCTIONAL REGULATION OF RECEPTORS FOR LIPID MEDIATORS
1998 - 1999 MECHANISM OF NEURONAL DEATH AND REGENERATION
1998 - 1998 血小板活性化因子(PAF)受容体の機能解析と制御
1997 - 1998 血小板活性化因子による皮膚細胞増殖の解析
1997 - 1998 Analysis of a nglammetroumechanisms mediated by Gprotein
1997 - 1998 Molecular Cloning and Signal Transduction of Leukotriene Receptors
1997 - 1998 Analysis of multiplicity and polymorphism of drug transporters expressed in the liver.
1997 - 1997 血小板活性化因子(PAF)受容体の機能解析と制御
1996 - 1997 Elucidation of roles of platelet-activating factor receptor by gene targeting.
1996 - 1996 血小板活性化因子受容体過剰発現マウスの皮膚色素沈着の解析
1996 - 1996 血小板活性化因子受容体の構造と機能
1996 - 1996 心筋細胞におけるPAF受容体機能の解析
1995 - 1996 Pathophysiology and Treatment of Endotoxin Shock
1995 - 1995 血小板活性化因子合成酵素の活性化機構の解析
1995 - 1995 血小板活性化因子(PAF)受容体の発現調節
1995 - 1995 トランスジェニックマウスを用いた心筋細胞におけるPAF受容体の解析
1994 - 1994 血小板活性化因子による増殖活性化機構の解析
1994 - 1994 トランスジェニックマウスを用いた心筋細胞におけるPAF受容体の解析
1994 - 1994 Gタンパク質を介する神経細胞死モデルを用いた情報伝達分子の解析
1993 - 1994 STUDIES ON PHYSIOLOGICAL FUNCTION OF PLATELET-ACTIVATING FACTOR
1993 - 1993 出芽酵母を用いた生理活性脂質の受容体遺伝子単離法の開発
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Papers (74):
Haruki Kato, Hiroyuki Nakagawa, Chiaki Ishizaki, Jun Tomita, Kazuhiko Kume. Preference of position in the proximity of various sugars revealed by location analysis of Drosophila melanogaster. Scientific Reports. 2024. 14. 1
Chihiro Inami, Makito Haruta, Yasumi Ohta, Motoshi Tanaka, MinHye So, Kazuya Sobue, Yasemin Akay, Kazuhiko Kume, Jun Ohta, Metin Akay, et al. Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca2+ imaging. Biochemical and Biophysical Research Communications. 2024. 708. 149800-149800
Sho T Yamaguchi, Sena Hatori, Koki T Kotake, Zhiwen Zhou, Kazuhiko Kume, Sam Reiter, Hiroaki Norimoto. Circadian control of sleep-related neuronal activity in lizards. PNAS nexus. 2024. 3. 1. pgad481
Riho Kobayashi, Yuko Yamashita, Hiroko Suzuki, Sena Hatori, Jun Tomita, Kazuhiko Kume. rdgB knockdown in neurons reduced nocturnal sleep in Drosophila melanogaster. Biochemical and Biophysical Research Communications. 2023. 643. 24-29
Riho Kobayashi, Shin Nakane, Jun Tomita, Hiromasa Funato, Masashi Yanagisawa, Kazuhiko Kume. A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in Drosophila. Frontiers in Neuroscience. 2023. 17
Junya Maruoka, Kei-ichiro Ishikura, Shinya Kato, Kazuhiko Kume, Masahiro Ohsawa. Involvement of astrocyte-neuron lactate shuttle dysfunction in the cognitive impairment in diabetic mice. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016. 19. 254-254
Akihiro Yamada, Noboru Inoue, Kazuhiko Kume, Masahiro Ohsawa. Possible role of astrocyte activation in diabetes-induced hippocampal dysfunction in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 211P-211P
J. Tomita, M. Mitsuyoshi, T. Ueno, Y. Aso, H. Tanimoto, S. Kume, K. Kume. NMDA receptor-calcineurin signaling function in promoting sleep in Drosophila. JOURNAL OF NEUROGENETICS. 2012. 26. 57-57