Rchr
J-GLOBAL ID：200901021007510832   Update date: Sep. 12, 2024

Tokunaga Kenzo

トクナガ ケンゾウ | Tokunaga Kenzo
Affiliation and department：
National Institute of Infectious Diseases Department of Pathology

About National Institute of Infectious Diseases Department of Pathology


Research field  (3)： Virology ,  Molecular biology ,  Cell biology
Research keywords  (5)： Retroviruses ,  HIV-1 ,  Host factors ,  Transmembrane proteins ,  MARCH8
Research theme for competitive and other funds  (14)：
  • 2021 - 2025 Investigations of the molecular mechanisms by which the host factor MARCH8 shows a broad antiviral spectrum
  • 2018 - 2021 Analyses of the antiviral spectrum of the novel host factor MARCH8
  • 2016 - 2019 感染動態・病態の連関解明に向けたHIV/AIDSの実証的研究
  • 2016 - 2017 エイズ関連悪性腫瘍誘発機序の理解と抗体療法の有効性評価
  • 2013 - 2015 エイズ関連悪性腫瘍誘発機序の理解と抗体療法の有効性評価
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Papers (96)：
  • TAKUYA TADA, Zhang Yanzhao, kong dechuan, Michiko Tanaka, Weitong YAO, Masanori Kameoka, Takamasa Ueno, Hideaki Fujita, Kenzo Tokunaga. Further Characterization of the Antiviral Transmembrane Protein MARCH8. Cells. 2024
  • Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C J M D S Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita. Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination. Membranes. 2024
  • Sho Miyamoto, Takara Nishiyama, Akira Ueno, Hyeongki Park, Takayuki Kanno, Naotoshi Nakamura, Seiya Ozono, Kazuyuki Aihara, Kenichiro Takahashi, Yuuki Tsuchihashi, et al. Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection. Proceedings of the National Academy of Sciences. 2023. 120. 52
  • Shigeru Fujita, Yusuke Kosugi, Izumi Kimura, Kenzo Tokunaga, Jumpei Ito, Kei Sato, Keita Matsuno, Naganori Nao, Hirofumi Sawa, Shinya Tanaka, et al. Determination of the factors responsible for the tropism of SARS-CoV-2-related bat coronaviruses to Rhinolophus bat ACE2. Journal of Virology. 2023. 97. 10
  • Terumasa Ikeda, MST Monira Begum, Kimiko Ichihara, Otowa Takahashi, Hesham Nasser, Michael Jonathan, Kenzo Tokunaga, Isao Yoshida, Mami Nagashima, Kenji Sadamasu, et al. Virological characteristics correlating with SARS-CoV-2 spike protein fusogenicity. 2023
ｍore...
MISC (7)：
  • 多田卓哉, 徳永研三. COVID-19とACE2. 腎と透析. 2022. 92. 1. 62-68
  • Downregulation of HIV-1 envelope glycoprotein by a novel host factor MARCH8. 2016. 66. 82-87
  • Kenzo TOKUNAGA. Identification of an antiviral host transmembrane protein MARCH8. Uirusu. 2015. 65. 2. 173-178
  • Molecular Confrontation between the Host Restriction Factor BST-2/Tetherin and Its Viral Antagonists. The Journal of AIDS Research. 2014. 16. 126-136
  • HIV-1 Restriction Factors. The Journal of AIDS Research. 2011. 13. 56-62
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Books (2)：
  • 1冊でわかる性感染症
    文光堂 2009 ISBN:9784830634536
  • Viral Genome Methods
    CRC Press 1996 ISBN:9781003420163
Lectures and oral presentations  (112)：
  • The development of in vitro HIV-1 latency models using a viral minigene system.
    (第70回日本ウイルス学会 2023)
  • Further Characterization of the antiviral transmembrane protein MARCH8.
    (第69回日本ウイルス学会 2022)
  • MARCH8 downregulates various viral envelope glycoproteins by targeting their cytoplasmic lysine residues.
    (第44回日本分子生物学会 2021)
  • MARCH8 targets cytoplasmic lysine residues of various viral envelope glycoproteins.
    (第68回日本ウイルス学会 2021)
  • The application of the HiBiT-based lentiviral system to SARS-CoV-2 studies.
    (第35回日本エイズ学会(日仏合同シンポジウム) 2021)
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Professional career (1)：
  • Ph.D. (Hokkaido University)
Work history (10)：
  • 2019/06 - 現在 Kumamoto University
  • 2018/04 - 現在 University of Yamanashi
  • 2001/04 - 現在 National Institute of Infectious Diseases
  • 2009/04 - 2018/03 Tokyo Medical and Dental University
  • 2010/04 - 2013/03 Research Institute for Microbial Diseases, Osaka University
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Committee career (6)：
  • 2022 - 現在 Viruses Special Issue Editor “Basic Sciences for the Conquest of COVID-19”
  • 2021 - 現在 日本エイズ学会 代議員
  • 2010 - 現在 Frontiers in Microbiology Review Editor in Virology
  • 2011 - 2012 Current HIV Research Guest Editor
  • 2012 - 第26回日本エイズ学会 プログラム委員
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Association Membership(s) (6)：
International AIDS Society ,  American Society for Biochemistry and Molecular Biology ,  American Society for Microbiology ,  日本分子生物学会 ,  日本エイズ学会 ,  日本ウイルス学会
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