Research field (4)：
Environmental impact assessment
, Environmental effects of chemicals
, Environmental effects of radiation
, Environmental policy and society
Research keywords (3)：
分子生物学
, 放射線生物学
, Rediation Biology
Research theme for competitive and other funds (44)：
2022 - 2025 メチル化シグネチャー解析による放射線の発がん寄与割合評価
2022 - 2025 ゲノム変異シグネチャー解析で紐解く低線量放射線の発がん寄与割合とメカニズム
2022 - 2025 Transcriptome analysis of radiation-induced genomic instability
2020 - 2023 ロングリード配列決定法による放射線被ばく刻印の同定
2020 - 2023 Optimization of nuclear medicine using physical and biological method in oncology
2019 - 2021 放射線誘発発がん変異のゲノム・エピゲノムシグニチャーの解明
2019 - 2020 生体期の生活習慣等の低線量放射線発がんリスクにおよぼす影響とメカニズム解明
2019 - 2020 組織における放射線障害および組織反応の解析
2019 - 2020 がん放射線治療の線量大幅低減と予後改善に向けた分子標的増感剤の探索
2016 - 2019 Molecular epidemiological study of thyroid cancers by international collaboration
2016 - 2018 Factors of radioresistance for oral cancer cells which were treated with KPU-300 radiosensitizing therapy.
2016 - 2018 Detection of radiation-induced oncogenic fusion in primary thyroid follicular cells
2014 - 2017 Molecular mechanism of epigenetic memory associated with DNA damage response
2013 - 2016 Development of instruction packages for new radiation education associated with the community
2013 - 2015 HTP screening of radiation protectors using chemical libraries
2011 - 2014 Mechanism of histone dimethylation regulating DNA damage response
2011 - 2012 Establishment of radiation-carcinogenesis system using culturedthyroid follicular cells
2010 - 2012 Elucidation of molecular mechanism on thyroid carcinogenesis anddevelopmental application of molecular targeting therapy
2007 - 2008 放射線被ばくによるヒト体性幹細胞におけるゲノム不安定性の研究
2007 - 2008 Role of MDC1/53BP1 in amplification of radiation-induced chromatin damage signal
2004 - 2008 Radiation-induced long-lived radicals causing mutation and carcinogenesis
2005 - 2006 Function of MDC1/53BP1 sensor chaperone in radiation-induced chromatin repair
2003 - 2004 The study on genomic instability initiated by radiation signature using the chromosome transfer techniue
2002 - 2003 ROLE OF BRCA1 IN RADIATION-INDUCED CENTROSOMAL CHECKPOINT
2001 - 2003 RADIATION-INDUCED LONG LIVED RADICALS CAUSING MUTATION AND TRANSFORMATION
2001 - 2001 放射線照射ヒト癌細胞における非アポトーシス性老化様増殖停止機構の解明
2000 - 2001 ATM-DEPENDENT PHOSPHORYLATION OF BRCA1 AND ITS BIOLOGICAL SIGNIFICANCE
2000 - 2000 放射線によるATM依存的なBRCA1蛋白質リン酸化とその意義
1999 - 2000 Involvement of telonomic instability in induction of delayed chromosome aberrations by ionizing radiation
1998 - 1999 DETERMINATION OF P53 PHOSPHORYLATION AND IDENTIFICATION OF P53-BINDING PROTEINS
1997 - 1999 AN IMPORTANT ROLE OF GENETICAL INSTABILITY IN RADIATION CARCINOGENESIS
1997 - 1997 GADD45による細胞増殖抑制メカニズムの解析
1994 - 1995 Genetical Instability induced by Low Doses of Radations
1993 - 1994 紫外線により誘導されるHSP72蛋白質の遺伝情報維持における役割
1993 - 1993 細胞接触を介した熱耐性発現機構の研究
1992 - 1992 放射線による細胞がん化における細胞形態変化の役割
1990 - 1990 放射線細胞がん化に伴って消失する蛋白(P240)と細胞骨格蛋白の相互作用
1988 - 1988 細胞がん化過程における染色体のトリソミー化の意義の実験的証明
がんの抑制と防御
環境ストレス反応を司る遺伝子の単離
放射線細胞応答と細胞がん化機構の解明
Suppression and protection of carcinogenesis
Identification of gene involring stress-resporse in cell
Clarification of radiation-stress response and radiation-induced Cancer
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Papers (189)：
Tatsuhiko Imaoka, Satoshi Tanaka, Masanori Tomita, Kazutaka Doi, Megumi Sasatani, Keiji Suzuki, Yutaka Yamada, Shizuko Kakinuma, Michiaki Kai. Human-mouse comparison of the multistage nature of radiation carcinogenesis in a mathematical model. International journal of cancer. 2024. 155. 6. 1101-1111
Kento Nagata, Mayumi Nishimura, Kazuhiro Daino, Yukiko Nishimura, Yuya Hattori, Ritsuko Watanabe, Daisuke Iizuka, Akinari Yokoya, Keiji Suzuki, Shizuko Kakinuma, et al. Luminal progenitor and mature cells are more susceptible than basal cells to radiation-induced DNA double-strand breaks in rat mammary tissue. Journal of radiation research. 2024
Kie Ozaki, Reona Kato, Takaaki Yasuhara, Yuki Uchihara, Miyako Hirakawa, Yu Abe, Hiroki Shibata, Reika Kawabata-Iwakawa, Aizhan Shakayeva, Palina Kot, et al. Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks. Scientific Reports. 2024. 14. 1
Yutaka Yamada, Tatsuhiko Imaoka, Toshiyasu Iwasaki, Junya Kobayashi, Munechika Misumi, Kazuo Sakai, Takashi Sugihara, Keiji Suzuki, Hiroshi Tauchi, Hiroshi Yasuda, et al. Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016-2023. Journal of radiation research. 2024
Ayaka Sako, Michiko Matsuse, Vladimir Saenko, Aya Tanaka, Ryota Otsubo, Michi Morita, Sayaka Kuba, Eijun Nishihara, Keiji Suzuki, Tomoo Ogi, et al. TERT promoter mutations increase tumor aggressiveness by altering TERT mRNA splicing in papillary thyroid carcinoma. The Journal of clinical endocrinology and metabolism. 2024
