Hiroki Konno

コンノヒロキ | Hiroki Konno

Affiliation and department：
Job title：准教授

Research field (1)： Functional biochemistry

Research keywords (3)：タンパク質の構造機能相関 , 高速原子間力顕微鏡 , 1分子計測

Research theme for competitive and other funds (15)：

2023 - 2027 The role of phase-separation upon radiation-induced DNA damages
2023 - 2026 Molecular mechanisms of the bacterial magnetic organelle surface proteins that functionalize the magnetosome as a biological magnetic needle
2022 - 高速原子間力顕微鏡を用いた子宮頸がん主要因タンパク質複合体の構造動態解明
2019 - 2021 ストレス依存的な細胞内外小胞の新規形態様式
2014 - 2019 Development of advanced high-speed AFM and analysis of proteins' action mechanism

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Papers (55)：

Kazuki Kasai, Kayo Imamura, Masatoshi Uno, Naotaka Sekiyama, Tomoko Miyata, Fumiaki Makino, Ryusei Yamada, Yoshiki Takahashi, Noriyuki Kodera, Keiichi Namba, et al. From Monomers to Oligomers: Structural Mechanism of Receptor-Triggered MyD88 Assembly in Innate Immune Signaling. 2024
Ayumi Sumino, Takashi Sumikama, Yimeng Zhao, Holger Flechsig, Kenichi Umeda, Noriyuki Kodera, Hiroki Konno, Motoyuki Hattori, Mikihiro Shibata. High-Speed Atomic Force Microscopy Reveals Fluctuations and Dimer Splitting of the N-Terminal Domain of GluA2 Ionotropic Glutamate Receptor-Auxiliary Subunit Complex. ACS Nano. 2024
Kazusa Takeda, Holger Flechsig, Ikumi Muro, Romain Amyot, Fuminori Kobayashi, Noriyuki Kodera, Toshio Ando, Hiroki Konno. Structural Dynamics of E6AP E3 Ligase HECT Domain and Involvement of a Flexible Hinge Loop in the Ubiquitin Chain Synthesis Mechanism. Nano Letters. 2023. 23. 24. 11940-11948
Tomoko Hirano, Kazuo Ebine, Takashi Ueda, Takumi Higaki, Takahiro Watanabe-Nakayama, Hiroki Konno, Hisako Takigawa-Imamura, Masa H Sato. The SYP123-VAMP727 SNARE complex delivers secondary cell wall components for root hair shank hardening in Arabidopsis. The Plant cell. 2023. 35. 12. 4347-4365
Masaharu Hazawa, Dini Kurnia Ikliptikawati, Yuki Iwashima, De-Chen Lin, Yuan Jiang, Yujia Qiu, Kei Makiyama, Koki Matsumoto, Akiko Kobayashi, Goro Nishide, et al. Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells. Cell Chemical Biology. 2023. 31. 4. 792-804

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MISC (30)：

佐藤雅彦, 海老根一生, 上田貴志, 檜垣匠, 中山隆宏, 紺野宏記, 今村寿子, 平野朋子. シロイヌナズナ根毛側面形成に関与する膜交通系の解明. 日本植物学会大会研究発表記録(CD-ROM). 2023. 87th
小野賢二郎, 中山隆宏, 辻まゆみ, 梅田健一, 小口達敬, 紺野宏記, 篠原もえ子, 木内祐二, 古寺哲幸, TEPLOW David B. 高速原子間力顕微鏡を用いたAβプロトフィブリルの構造動態とレカネマブの作用. Dementia Japan. 2023. 37. 4
佐藤雅彦, 海老根一生, 上田貴志, 檜垣匠, 紺野宏記, 中山隆宏, 平野朋子. SYP123-VAMP727 is involved in the secretion of the inner cell wall components to the root hair shank in Arabidopsis. 日本植物生理学会年会(Web). 2022. 63rd
紺野宏記, 羽澤勝治, 芳坂綾子, 佐々木理乃, 矢幡信成, 古寺哲幸, 安藤敏夫. Investigation of formation process of Prx high molecular weight complexes and its physiological significance. 日本生体エネルギー研究会討論会講演要旨集. 2020. 46th
室郁弥, 中山(渡辺)隆宏, 古寺哲幸, 安藤敏夫, 紺野宏記. Observation of the structural dynamics of HECT-type ubiquitin ligase using high-speed AFM. 日本生体エネルギー研究会討論会講演要旨集. 2020. 46th

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Books (4)：

Time lapseimaging of amiroid fibril growth of yeast prion
2020
高速原子間力顕微鏡(HS-AFM)を活用したユビキチン修飾過程の動的分子プロセス解明
ニューサイエンス社 2015
葉緑体ATP合成酵素の回転を制御スイッチで操る
バイオインダストリー協会 2010
光合成研究法
北海道大学低温科学研究所 2009

Lectures and oral presentations (70)：

高速原子間力顕微鏡(高速AFM)を活用した生体機能の動的分子プロセスの解明
(令和6年度静岡県立大第3回環境科学専攻月例セミナー 2024)
formation of 2-Cys peroxiredoxin (Prx2) high molecular weight complex
(2024)
Investigation of structural dynamics of E6AP/E6/p53 complex by using HS-AFM and computational simulation
(2024)
High-Speed Atomic Force Microscopy Reveals Structural Dynamics of Microtubule-Associated Protein Tau Aggregation
(IUPAB 2024 2024)
ペルオキシレドキシンの細胞間輸送プロセスにおける働きと脂質に依存した複合体の形成メカニズムの解明
(日本生化学会北陸支部第42回大会 2024)

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Education (4)：

1999 - 2002 Tokyo Institute of Technology Interdisciplinary Graduate School of Science and Engineering Department of Electronic Chemistry
1997 - 1999 Kanazawa University
1995 - 1997 Kanazawa University
1990 - 1994 Hokkaido Pharmaceutical University School of Pharmacy Department of Pharmacy Department of Pharmacy

Professional career (1)：

Doctor of Science (Tokyo Institute of Technology)

Work history (7)：

2017/10 - 現在 Kanazawa University
2011/11 - 2017/09 Kanazawa University
2009/08 - 2011/10 Tokyo Institute of Technology Chemical Resources Laboratory, Resources Recycling Process Laboratory, Chemical Resources Laboratory Resources Recycling Process Laboratory Assistant Professor
2005/08 - 2009/07 -:東京工業大学資源化学研究所助手
2002/04 - 2005/07 :科学技術振興機構 ERATO ATP システムプロジェクト研究員

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Committee career (3)：

2020/03 - 2020/12 日本生体エネルギー研究会第46回討論会代表世話人
2014 - 2016 日本生化学会北陸支部幹事
2015 - 2015 日本生物物理学会第53回日本生物物理学会実行委員

Awards (1)：

2018/09 - Biophysics and Physicobiology Editors' Choice Award 2018 Demonstration of correlative atomic force and transmission electron microscopy using actin cytoskeleton

Association Membership(s) (3)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE BIOPHYSICAL SOCIETY OF JAPAN

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