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J-GLOBAL ID：200901025039482623 Update date: Jan. 31, 2025

Ishikawa Yoshinobu

イシカワヨシノブ | Ishikawa Yoshinobu

Affiliation and department：
Job title：教授
Homepage URL (2)： https://sites.google.com/view/sumsanalchem/ホーム , https://sites.google.com/view/sumsanalchem/english?authuser=0

Research field (2)： Pharmaceuticals - analytical and physicochemistry , Pharmaceuticals - chemistry and drug development

Research keywords (19)： PD-L1 , PD-1 , AS-MS , 天然物 , 配座解析 , AutoDock , AMBER , Gaussian , インシリコ創薬 , ヴァーチャルスクリーニング , 分子動力学シミュレーション , 分子ドッキング , 免疫チェックポイント阻害剤 , 分子間相互作用 , 生物無機化学 , 医薬分子機能学 , 分子モデリング , X線結晶構造解析 , ドラッグデザイン

Research theme for competitive and other funds (20)：

2024 - 2027 AS-MSによるPD-1ーPD-L1低分子阻害剤の探索
2022 - 2025 新規抗がん剤開発を目指すtRNA修飾酵素と阻害化合物の構造活性相関解明
2020 - 2023 Innovative drug development targeting specific DNA repair pathway in cancer cells
2020 - 2023 膠芽腫幹細胞を標的としたtRNAメチル化酵素阻害剤による制がん戦略の構築
2019 - 2022 がんゲノム解析で蓄積する機能未知遺伝子変異の臨床活用にむけた変異機能推定法の構築

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Papers (130)：

Buyanmandakh Buyankhishig, Toshihiro Murata, Koichi Narita, Chinbat Delgermaa, Yoshifumi Nishikawa, Nanang R Ariefta, Baasandorj Gantumur, Tseesuren Byambajav, Yoshinobu Ishikawa, Bekh-Ochir Davaapurev, et al. Isolation of Antiplasmodial Oxazoles and Isoflavonoids from the Roots of Oxytropis trichophysa and Total Synthesis of Oxazole-type Alkaloids. Journal of natural products. 2025
Yuko Mizukami, Shotaro Hashimoto, Tomoka Ando, Yoshinobu Ishikawa, Hiroaki Eguchi, Yuta Yoshino, Toshiyuki Matsunaga, Nobuhisa Matsuhashi, Akira Ikari. Reduction of Chemoresistance by Claudin-14-Targeting Peptide in Human Colorectal Cancer Cells. Journal of cellular biochemistry. 2024. e30675
Nanami Kurosawa, Yohei Takeda, Yoshimi Ichimaru, Dulamjav Jamsransuren, Sachiko Matsuda, Yoshinobu Ishikawa, Minori Yamaguchi, Haruko Ogawa, Kenroh Sasaki, Toshihiro Murata. Chemical constituents of five Saxifraga species and their virucidal activities. Fitoterapia. 2024. 179. 106215-106215
村田敏拓, Nurbyek Stipan, 菅沼啓輔, 市丸嘉, Buyanmandakh Buyankhishig, 黒澤七海, 石川吉伸, Bekh-Ochir Davaapurev, 佐々木健郎, Batkhuu Javzan. Artemisia adamsiiより得た新規セスキテルペノイドと抗トリパノソーマ活性成分. 日本生薬学会年会講演要旨集. 2024. 70回. 150-150
Yuko Mizukami, Ayaka Ito, Shotaro Hashimoto, Yoshinobu Ishikawa, Hiroaki Eguchi, Yuta Yoshino, Toshiyuki Matsunaga, Shohei Hamada, Takumi Furuta, Akira Ikari. Downregulation of chemoresistance by claudin;silencing in human colorectal cancer cells. Archives of Biochemistry and Biophysics. 2024. 758. 110075

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MISC (11)：