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J-GLOBAL ID：200901025551854869 Update date: Jan. 31, 2024

Saeki Makio

サエキマキオ | Saeki Makio

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Affiliation and department：
Homepage URL (1)： http://www.dent.niigata-u.ac.jp/pharmacology/pharmacology.html

Research field (1)： Oral medicine

Research keywords (5)： Neuropharmacology , Pharmacology , 腫瘍 , Monad , R2TP複合体

Research theme for competitive and other funds (29)：

2021 - 2024 低酸素微小環境を標的としたコルジセピン誘導体による口腔がん治療の検討
2020 - 2023 口腔扁平上皮癌におけるR2TPのターゲット解析と治療標的としての可能性の検討
2019 - 2022 Elucidation of mechanism on congenital abnormality in the maxillofacial region focusing on DNA repair mechanism
2018 - 2021 Elucidation of fate path and regulatory factors of periodontal ligament tissue stem cells
2017 - 2020 Challenges to development of "bioregenerative therapy"

2017 - 2020 Analysis of the molecular mechanism of the mechanical stress response in osteoblasts through primary cilia

2017 - 2020 Study for elucidating indiction mechanism of stem cells by manipulation molecule

2018 - 2020 難治性口腔扁平上皮癌におけるセツキシマブ耐性ループ仮説の検証

2014 - 2016 Golgi-localized Fam20C phosphorylation and osteocyte functions

2013 - 2016 Establishment of iPS cell-based bone tissue engineering using small molecule compounds

2013 - 2015 Development of the new method to control the resorption of alveolar bone, targeting receptor acting on bone - nervous system

2012 - 2015 Role of Monad-interacting complex on tumorigenesis

2012 - 2015 Ultramicrostructural analysis of biomineralization processes of DMP1

2011 - 2013 Reguratiion for invasion of OSCC by reptin

2011 - 2012 Trial research of fibrous dysplasia model transplanted with GNAS1 mutant cells

2010 - 2012 Development of cell-based screening system for identifying osteogenesis-targeting compounds

2010 - 2011 Analysis of bone regeneration using small-molecule harmine and Id2-knockout mice

2009 - 2011 Elucidation of the mechanism of biomineralization with acidic phosphoprotein from molecular evolution studies

2008 - 2010 Therapeutic strategies against bone resorption using calcineurin signaling in osteoclast

2008 - 2010 Investigation for apoptosis regulation system of Monad and its application on therapy of oral tumors

2006 - 2007 口腔形成制御に繋がる新規カルシウム結合タンパク質の同定と解明

2006 - 2007 キメラの内軟骨性骨化モデルを利用した骨芽細胞分化における血管の役割解明

2006 - 2007 Calcineurin-induced apoptosis and TMD

2005 - 2007 Produdion of transgenic mice and functional analysis ofosteaytesusingcis-regulatory regions

2002 - 2004 Effect of protein nitration on peri-gingivitis and inflammatory regulation mechanism involving nitration and de-nitration.

2000 - 2001 Direct and indirect effects of nitric oxide on nociceptive signal transduction at the trigeminal nucleus caudalis and mechanism for the regulation

1999 - 2000 Effects of nitric oxide on pain perception by primary afferent neurons in inflammation

1997 - 1998 Regulation of beta-agonist-induced secretion of amylase from rat parotid acini by K^+-channels

[急がば回れ」の骨再生:骨吸収促進薬を用いた新規骨疾患治療薬の探索

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Papers (59)：

Lay Thant, Yoshito Kakihara, Masaru Kaku, Megumi Kitami, Kohei Kitami, Masaru Mizukoshi, Takeyasu Maeda, Isao Saito, Makio Saeki. Involvement of Rab11 in osteoblastic differentiation: Its up-regulation during the differentiation and by tensile stress. Biochemical and biophysical research communications. 2022. 624. 16-22
Sho Fukuyasu, Hiroki Kayashima, Akihito Moribayashi, Shu Matsuoka, Atsuhiro Nagasaki, Hiroko Okawa, Hirofumi Yatani, Makio Saeki, Hiroshi Egusa. Cell-Based Double-Screening Method to Identify a Reliable Candidate for Osteogenesis-Targeting Compounds. Biomedicines. 2022. 10. 2. 426-426
Keiichiro Okamoto, Mana Hasegawa, Kajita Piriyaprasath, Yoshito Kakihara, Makio Saeki, Kensuke Yamamura. Preclinical models of deep craniofacial nociception and temporomandibular disorder pain. Japanese Dental Science Review. 2021. 57. 231-241
Keiichiro Okamoto, Yoshito Kakihara, Naoto Ohkura, Aiko Tohma, Ayako Washio, Chiaki Kitamura, Yuichiro Noiri, Kensuke Yamamura, Makio Saeki. Effects of rice fermented extracts, "Sake Lees", on the functional activity of odontoblast-like cells (KN-3 cells). Odontology. 2021. 110. 2. 254-261
Thant Lay, 加来賢, 柿原嘉人, 水越優, 北見恩美, 北見公平, 小林大記, 吉田豊, 魚島勝美, 齋藤功, et al. メカニカルストレス下における歯根膜細胞外基質タンパクのプロテオーム解析. 日本結合組織学会学術大会プログラム・抄録集. 2021. 53回. 137-137

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MISC (28)：

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Education (2)：

- 1995 Osaka University Faculty of Dentistry
- 1995 Osaka University School of Dentistry

Professional career (1)：

Doctor of Philosophy (Osaka University)

Work history (2)：

2014/02 - Niigata University Graduate School of Medical and Dental Sciences, Oral Life Science
1995/04 - Osaka University Graduate School of Dentistry, Course for Integrated Oral Sciences and Stomatology

Association Membership(s) (3)：

歯科基礎医学会 , 日本薬理学会 , JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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