Rchr
J-GLOBAL ID：200901029457031234
Update date: Sep. 23, 2024
Takehara Tetsuo
タケハラ テツオ | Takehara Tetsuo
Affiliation and department：
Research field (1)：
Gastroenterology
Research theme for competitive and other funds (41)：
- 2022 - 2024 癌微小環境の形質的・空間的多様性を介したがん細胞クローン拡大機構の解明
- 2021 - 2024 Elucidation of hepatic progenitor cell-derived carcinogenic mechanism via p53 activation in hepatocytes
- 2018 - 2021 Elucidation of the mechanism of pancreatic cancer metastasis using single cell analysis technology and innovative mouse models
- 2018 - 2021 Cell-to-cell communication and pathogenesis triggered by hepatocyte cell death in the liver
- 2017 - 2019 障害ミトコンドリアからのダイイングコード漏出による脂肪性肝疾患の進展機序の解明
- 2016 - 2018 肝細胞と脂肪細胞におけるRubiconを介した脂肪代謝の制御
- 2016 - 2018 Treatment for acute pancreatitis by regulating autophagy which modulates zymogen granules and inflammasomes
- 2014 - 2018 The impact of hepatocyte apoptosis and autophagy in the process of livercarcinogenesis
- 2015 - 2017 Development of experimental model of Chronic Intestinal Pseudo-obstruction (CIPO) using iPS and drug discovery research
- 2014 - 2016 Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression
- 2012 - 2015 Development of biomarkers using cancer cells derived from clinical samples
- 2012 - 2014 Crosstalk between CagA and inflammation in H. pylori-related gastric carcinogenesis.
- 2012 - 2014 Molecular mechanisms of acinar cell injury in acute pancreatitis
- 2012 - 2014 膵癌におけるバイオマーカーの探索ーCTOS法を用いた検討
- 2011 - 2014 Regulation of autophagy and its impact in the development and progression of hepatocellular cancer.
- 2012 - 2012 肝細胞CTGFによる肝線維化・肝発癌制御機構の解明
- 2010 - 2012 Development of novel therapy for hepatocellular carcinoma targeting of bone marrow-derived angiogenesis precursor
- 2009 - 2011 Bcl-2 network and regulation of cell death in non-alcoholic steatohepatitis
- 2009 - 2011 The role of STATs molecule through cancer development
- 2009 - 2011 Controlling HCV replication by targeting intracellular signaling
- 2009 - 2011 Analysis of interferon-τsignaling in immune cells of patients with hepatitis C virus infection to establish effective therapeutic strategy.
- 2009 - 2011 Immunological analysis of liver cancer stem cells and immunotherapy
- 2008 - 2010 Molecular mechanism of the ectodomain shedding of the NKG2D ligand MHC class I-related chain A in hepatocellular carcinoma and its therapeutic implication
- 2008 - 2010 Immunological analysis and new immunotherapy of chronic hepatitis C
- 2007 - 2009 Developmental research on dendritic cell-based immunotherapy against chronic hepatitis C and hepatocellular carcinoma
- 2007 - 2008 非アルコール性脂肪性肝疾患と肝硬変におけるオートファジーの解析とその意義の解明
- 2007 - 2008 Analysis of activation of dendritic cells by γ-PGA nano-particle and liver cancer immunotherapy
- 2006 - 2007 Hepatitis B virus mutations affecting synthesis of relaxed-circular viral DNA : Relation to disease severity
- 2006 - 2007 Molecular regulation of NK cell cytotoxicity fir human hepatocellular carcinoma
- 2003 - 2007 Regulation of dendritic cell function and cell-based therapy in chronic hepatitis C virus infection
- 2005 - 2006 HBV遺伝子導入マウスでの酵素阻害剤誘発変異の解析とテーラーメイド医療への応用
- 2005 - 2006 Molecular analysis of dendritic cell based vaccines against liver cancer
- 2004 - 2006 Establishment of plasmacytoid dendritic cell-based immune therapy against viral hepatitis and hepatocellular carcinoma
- 2004 - 2005 Natural killer receptor-mediated regulation of dendritic cell functions in chronic hepatitis C
- 2002 - 2003 Suppression of hepatocarcinogenesis by activating natural killer T cells
- 肝癌の免疫治療に関する研究
- Study on Viral Hepatitis by in vivo Gene Transfer
- Study on Apoptosis of Hepatocyte
- 遺伝子導入を用いたウイルス肝炎モデルの作成
- 肝細胞のアポトーシスに関する研究
- Study on Immunotherapy for Liver Cancer
Show all
Papers (643)：
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Kai Y, Hikita H, Morishita N, Murai K, Nakabori T, Iio S, Hagiwara H, Imai Y, Tamura S, Tsutsui S, et al. Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment. Scientific Reports. 2107
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Emi Sometani, Hayato Hikita, Kazuhiro Murai, Hidenori Toyoda, Satoshi Tanaka, Tsugiko Oze, Jihyun Sung, Akiyoshi Shimoda, Makoto Fukuoka, Satoshi Shigeno, et al. High serum growth differentiation factor 15 is a risk factor for the occurrence of hepatocellular carcinoma in chronic hepatitis B patients treated with nucleos(t)ide analogs. Hepatology research : the official journal of the Japan Society of Hepatology. 2024
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Yukiko Ueyama-Toba, Yanran Tong, Jumpei Yokota, Kazuhiro Murai, Hayato Hikita, Hidetoshi Eguchi, Tetsuo Takehara, Hiroyuki Mizuguchi. Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research. iScience. 2024. 27. 9. 110778-110778
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Shusuke Kumazaki, Hayato Hikita, Yuki Tahata, Ji Hyun Sung, Kenji Fukumoto, Yuta Myojin, Sadatsugu Sakane, Kazuhiro Murai, Yoichi Sasaki, Kumiko Shirai, et al. Serum growth differentiation factor 15 is a novel biomarker with high predictive capability for liver cancer occurrence in patients with MASLD regardless of liver fibrosis. Alimentary pharmacology & therapeutics. 2024
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Sadatsugu Sakane, Hayato Hikita, Kumiko Shirai, Tatsuya Sakamoto, Ryohei Narumi, Jun Adachi, Naruyasu Kakita, Yukinori Yamada, Hidenori Toyoda, Hirokazu Takahashi, et al. Proteomic analysis of serum extracellular vesicles reveals Fibulin-3 as a new marker predicting liver-related events in MASLD. Hepatology communications. 2024. 8. 6
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MISC (1,362)：
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村井 一裕, 疋田 隼人, 竹原 徹郎. ウイルス性肝炎研究Cutting edge(A-E型,小児肝炎AAV2,創薬研究) HSPG2発現抑制がcMET発現上昇とPPARγ発現低下を介してHBVの侵入ならびに複製を阻害する. 肝臓. 2024. 65. Suppl.1. A115-A115
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新海 数馬, 疋田 隼人, 前阪 和城, 土居 哲, 田畑 優貴, 村井 一裕, 齋藤 義修, 西尾 啓, 古田 訓丸, 小玉 尚宏, et al. 当院における原発性硬化性胆管炎患者の現状. 肝臓. 2024. 65. Suppl.1. A352-A352
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村井 一裕, 疋田 隼人, 下田 彬允, 栗木 真治, 染谷 愛美, 成 志弦, 福岡 誠, 滋野 聡, 西尾 啓, 小玉 尚宏, et al. HBs抗原を減少させる化合物を同定するFDA承認薬ライブラリースクリーニング. 肝臓. 2024. 65. Suppl.1. A364-A364
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福岡 誠, 小玉 尚宏, 村井 一裕, 栗木 真治, 染谷 愛美, 成 志弦, 下田 彬允, 滋野 聡, 西尾 啓, 疋田 隼人, et al. CRISPRスクリーニングによるHBV関連肝癌の脆弱性因子の探索. 肝臓. 2024. 65. Suppl.1. A494-A494
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田畑 優貴, 疋田 隼人, 持田 智, 三木 大樹, 井戸 章雄, 榎本 信幸, 阪森 亮太郎, 竹原 徹郎. C型非代償性肝硬変における抗ウイルス治療後の食道胃静脈瘤悪化に関与する因子の検討. 日本内科学会雑誌. 2024. 113. 臨増. 170-170
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Works (3)：
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肝癌幹細胞に対する癌免疫治療とその分子機構の解析
2009 -
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ナノテクノロジーを用いた樹状細胞活性化機構の解析と肝癌免疫治療
2008 -
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ナノテクノロジーを用いた樹状細胞活性化機構の解析と肝癌免疫治療
2007 -
Professional career (1)：
- (BLANK) (Osaka University)
Committee career (2)：
Awards (2)：
- 1997 - 日本内科学会奨励賞
- 1996 - 日本肝臓学会研究奨励賞
Association Membership(s) (7)：
日本肝臓学会
, 日本癌学会
, 日本内科学会
, 日本免疫学会
, American Association for the Study of Liver Diseases
, 日本消化器病学会
, 日本消化器内視鏡学会
