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J-GLOBAL ID：200901029457031234 Update date: Apr. 18, 2025

Takehara Tetsuo

タケハラテツオ | Takehara Tetsuo

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Affiliation and department：

Research field (1)： Gastroenterology

Research theme for competitive and other funds (41)：

2022 - 2024 癌微小環境の形質的・空間的多様性を介したがん細胞クローン拡大機構の解明
2021 - 2024 Elucidation of hepatic progenitor cell-derived carcinogenic mechanism via p53 activation in hepatocytes
2018 - 2021 Elucidation of the mechanism of pancreatic cancer metastasis using single cell analysis technology and innovative mouse models
2018 - 2021 Cell-to-cell communication and pathogenesis triggered by hepatocyte cell death in the liver
2017 - 2019 障害ミトコンドリアからのダイイングコード漏出による脂肪性肝疾患の進展機序の解明

2016 - 2018 肝細胞と脂肪細胞におけるRubiconを介した脂肪代謝の制御

2016 - 2018 Treatment for acute pancreatitis by regulating autophagy which modulates zymogen granules and inflammasomes

2014 - 2018 The impact of hepatocyte apoptosis and autophagy in the process of livercarcinogenesis

2015 - 2017 Development of experimental model of Chronic Intestinal Pseudo-obstruction (CIPO) using iPS and drug discovery research

2014 - 2016 Significance of connective tissue growth factor (CTGF) and tumor-stroma interaction in Kras-driven hepatocarcinogenesis and HCC progression

2012 - 2015 Development of biomarkers using cancer cells derived from clinical samples

2012 - 2014 Crosstalk between CagA and inflammation in H. pylori-related gastric carcinogenesis.

2012 - 2014 Molecular mechanisms of acinar cell injury in acute pancreatitis

2012 - 2014 膵癌におけるバイオマーカーの探索ーCTOS法を用いた検討

2011 - 2014 Regulation of autophagy and its impact in the development and progression of hepatocellular cancer.

2012 - 2012 肝細胞CTGFによる肝線維化・肝発癌制御機構の解明

2010 - 2012 Development of novel therapy for hepatocellular carcinoma targeting of bone marrow-derived angiogenesis precursor

2009 - 2011 Bcl-2 network and regulation of cell death in non-alcoholic steatohepatitis

2009 - 2011 The role of STATs molecule through cancer development

2009 - 2011 Controlling HCV replication by targeting intracellular signaling

2009 - 2011 Analysis of interferon-τsignaling in immune cells of patients with hepatitis C virus infection to establish effective therapeutic strategy.

2009 - 2011 Immunological analysis of liver cancer stem cells and immunotherapy

2008 - 2010 Molecular mechanism of the ectodomain shedding of the NKG2D ligand MHC class I-related chain A in hepatocellular carcinoma and its therapeutic implication

2008 - 2010 Immunological analysis and new immunotherapy of chronic hepatitis C

2007 - 2009 Developmental research on dendritic cell-based immunotherapy against chronic hepatitis C and hepatocellular carcinoma

2007 - 2008 非アルコール性脂肪性肝疾患と肝硬変におけるオートファジーの解析とその意義の解明

2007 - 2008 Analysis of activation of dendritic cells by γ-PGA nano-particle and liver cancer immunotherapy

2006 - 2007 Hepatitis B virus mutations affecting synthesis of relaxed-circular viral DNA : Relation to disease severity

2006 - 2007 Molecular regulation of NK cell cytotoxicity fir human hepatocellular carcinoma

2003 - 2007 Regulation of dendritic cell function and cell-based therapy in chronic hepatitis C virus infection

2005 - 2006 HBV遺伝子導入マウスでの酵素阻害剤誘発変異の解析とテーラーメイド医療への応用

2005 - 2006 Molecular analysis of dendritic cell based vaccines against liver cancer

2004 - 2006 Establishment of plasmacytoid dendritic cell-based immune therapy against viral hepatitis and hepatocellular carcinoma

2004 - 2005 Natural killer receptor-mediated regulation of dendritic cell functions in chronic hepatitis C

2002 - 2003 Suppression of hepatocarcinogenesis by activating natural killer T cells

肝癌の免疫治療に関する研究

Study on Viral Hepatitis by in vivo Gene Transfer

Study on Apoptosis of Hepatocyte

遺伝子導入を用いたウイルス肝炎モデルの作成

肝細胞のアポトーシスに関する研究

Study on Immunotherapy for Liver Cancer

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Papers (661)：

Kai Y, Hikita H, Morishita N, Murai K, Nakabori T, Iio S, Hagiwara H, Imai Y, Tamura S, Tsutsui S, et al. Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment. Scientific Reports. 2107
Eiji Kimura, Yoshito Hayashi, Kentaro Nakagawa, Hirotsugu Saiki, Minoru Kato, Ryotaro Uema, Takanori Inoue, Takeo Yoshihara, Akihiko Sakatani, Hiromu Fukuda, et al. p53 Deficiency in Colon Cancer Cells Promotes Tumor Progression Through the Modulation of Meflin in Fibroblasts. Cancer science. 2025
Yoshihisa Kodama, Kazuomi Ueshima, Michihisa Moriguchi, Yoshitaka Inaba, Tatsuya Yamashita, Hideki Iwamoto, Makoto Ueno, Sadahisa Ogasawara, Teiji Kuzuya, Takahiro Kodama, et al. Protocol of the IMPACT study: randomized, multicenter, phase 3 study evaluating the efficacy of immunotherapy (Atezolizumab) plus anti-VEGF therapy (Bevacizumab) in combination with transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma. BMC cancer. 2025. 25. 1. 434-434
Shinnosuke Kudo, Hayato Hikita, Yoshinobu Saito, Kazuhiro Murai, Takahiro Kodama, Tomohide Tatsumi, Tetsuo Takehara. Collaborative orchestration of BH3-only proteins governs Bak/Bax-dependent hepatocyte apoptosis under antiapoptotic protein-deficiency in mice. Cell death and differentiation. 2025
Kentaro Nakagawa, Yoshito Hayashi, Yujiro Adachi, Ayaka Tajiri, Hiromu Fukuda, Eiji Kimura, Ryotaro Uema, Hirotsugu Saiki, Minoru Kato, Takanori Inoue, et al. Low skeletal muscle mass contributes to the prognosis of patients with superficial esophageal cancer treated with definitive chemoradiotherapy. Esophagus : official journal of the Japan Esophageal Society. 2025

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MISC (1,387)：

Akiyoshi Shimoda, Hayato Hikita, Kazuhiro Murai, Takayuki Miyake, Shinji Kuriki, Emi Sometani, Jihyun Sung, Satoshi Shigeno, Kumiko Shirai, Yuki Tahata, et al. FDA APPROVED DRUG LIBRARY SCREENING TO IDENTIFY COMPOUNDS THAT REDUCE HBS ANTIGEN. HEPATOLOGY. 2024. 80. S211-S212
Yoshinobu Saito Hayato Hikita, Tomoya Hamabe, Yoichi Sasaki, Shinnosuke Kudo, Kazuhiro Murai, Takahiro Kodama, Tetsuo Takehara. INVESTIGATION FOR A ROLE OF NON-APOPTOTIC CELL DEATH IN THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA. HEPATOLOGY. 2024. 80
Jihyun Sung, Hayato Hikita, Yuki Makino, Seiya Kato, Yoichi Sasaki, Kenji Fukumoto, Kazuhiro Murai, Yoshinobu Saito, Takahiro Kodama, Tomohide Tatsumi, et al. ACTIVATION OF HEPATOCYTE P53 TRIGGERS ACUTE LIVER FAILURE WITH MULTIPLE ORGAN INJURY. HEPATOLOGY. 2024. 80. S1583-S1584
Kazuhiro Murai, Hayato Hikita, Ryoko Yamada, Takayuki Miyake, Emi Sometani, Shinji Kuriki, Jihyun Sung, Akiyoshi Shimoda, Satoshi Shigeno, Yuki Tahata, et al. RISK FACTORS ASSOCIATED WITH HEPATOCELLULAR CARCINOMA OCCURRENCE IN CHRONIC HEPATITIS B PATIENTS ON LONG-TERM NUCLEOS(T) IDE ANALOGUES. HEPATOLOGY. 2024. 80. S182-S182
Shuhei Yamamoto, Takahiro Kodama, Kazuki Maesaka, Akifumi Kuwano, Kenta Motomura, Kumiko Shirai, Akira Doi, Kazuhiro Murai, Yuki Tahata, Yoshinobu Saito, et al. NRF2-MEDIATED IMMUNE COLD TUMOR MICROENVIRONMENT CONTRIBUTES TO RESISTANCE TO ATEZOLIZUMAB AND BEVACIZUMAB IN ADVANCED HEPATOCELLULAR CARCINOMA. HEPATOLOGY. 2024. 80

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Works (3)：

肝癌幹細胞に対する癌免疫治療とその分子機構の解析
2009 -
ナノテクノロジーを用いた樹状細胞活性化機構の解析と肝癌免疫治療
2008 -
ナノテクノロジーを用いた樹状細胞活性化機構の解析と肝癌免疫治療
2007 -

Professional career (1)：

(BLANK) (Osaka University)

Committee career (2)：

日本肝臓学会評議員
日本消化器病学会評議員

Awards (2)：

1997 - 日本内科学会奨励賞
1996 - 日本肝臓学会研究奨励賞

Association Membership(s) (7)：

日本肝臓学会 , 日本癌学会 , 日本内科学会 , 日本免疫学会 , American Association for the Study of Liver Diseases , 日本消化器病学会 , 日本消化器内視鏡学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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