Rchr
J-GLOBAL ID：200901029942045456   Update date: Jun. 13, 2024

Mano Hiroyuki

マノ ヒロユキ | Mano Hiroyuki
Affiliation and department：
The University of Tokyo Division of Functional Genomics

About The University of Tokyo Division of Functional Genomics


Job title： Professor
Research field  (1)： Molecular biochemistry
Research keywords  (4)： carcinogenesis ,  genomics ,  Oncogene ,  Genomics
Research theme for competitive and other funds  (43)：
  • 2010 - 2016 Integrative Research on Cancer Microenvironment Network
  • 2010 - 2012 Basic study of immunotherapy with peptide vaccine in PNH
  • 2005 - 2009 Molecular targeted therapy of hematological malignancies based on the genomic information
  • 2003 - 2005 Development of a new classification for AML based on the gene expression profile in leukemia stem cells.
  • 2001 - 2004 本態性高血圧症および心不全発症機構に関する包括的ゲノム解析
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Papers (198)：
  • Shinji Kohsaka, Shigehiro Yagishita, Yukina Shirai, Yusuke Matsuno, Toshihide Ueno, Shinya Kojima, Hiroshi Ikeuchi, Masachika Ikegami, Rina Kitada, Ken-ichi Yoshioka, et al. A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency. npj Precision Oncology. 2024. 8. 1
  • Kousuke Watanabe, Shinji Kohsaka, Kenji Tatsuno, Aya Shinozaki-Ushiku, Hideaki Isago, Hidenori Kage, Tetsuo Ushiku, Hiroyuki Aburatani, Hiroyuki Mano, Katsutoshi Oda. Analysis of quality metrics in comprehensive cancer genomic profiling using a dual DNA-RNA panel. Practical laboratory medicine. 2024. 39. e00368
  • Yukina Shirai, Toshihide Ueno, Shinya Kojima, Hiroshi Ikeuchi, Rina Kitada, Takafumi Koyama, Fumiyuki Takahashi, Kazuhisa Takahashi, Koichi Ichimura, Akihiko Yoshida, et al. The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma. Journal of neuro-oncology. 2024
  • Shogo Takei, Yosuke Tanaka, Yi-Tzu Lin, Shohei Koyama, Shota Fukuoka, Hiroki Hara, Yoshiaki Nakamura, Yasutoshi Kuboki, Daisuke Kotani, Takashi Kojima, et al. Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer. Journal for immunotherapy of cancer. 2024. 12. 2
  • Bunpei Miyazaki, Toshihide Ueno, Masanaka Sugiyama, Shinya Kojima, Ayumu Arakawa, Kayoko Tao, Kazuki Tanimura, Kouya Shiraishi, Shigehiro Yagishita, Shinji Kohsaka, et al. Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia. npj Precision Oncology. 2023. 7. 1
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MISC (81)：
  • 熊谷 尚悟, 小山 正平, 板橋 耕太, 冨樫 庸介, 吉田 達哉, 石井 源一郎, 河津 正人, 山崎 直也, 坪井 正博, 谷田部 恭, et al. 腫瘍微小環境における制御性T細胞に特徴的な代謝学的チェックポイントの同定(Identification of a distinctive metabolic checkpoint of regulatory T cells in the tumor microenvironment). 日本癌学会総会記事. 2022. 81回. CES1-3
  • 石野 貴雅, 上野 敏秀, 上田 優輝, 間野 博行, 石原 聡一郎, 加藤 直也, 河津 正人, 冨樫 庸介. その機能がnon-inflamedな腫瘍微小環境を誘導し得る逆説的なネオ抗原の存在(Paradoxical neoantigens; neoantigens can paradoxically induce a non-inflamed tumor microenvironment via gene functions.). 日本癌学会総会記事. 2022. 81回. P-2171
  • Shinobu Tsuzuki, Takahiko Yasuda, Masahito Kawazu, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Masashi Sanada, Hirokazu Nagai, Akihiro Tomita, Yoshiyuki Takahashi, et al. Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. CANCER SCIENCE. 2022. 113. 1236-1236
  • Yosuke Tanaka, Fumiko Chiwaki, Shinya Kojima, Masahito Kawazu, Masayuki Komatsu, Toshihide Ueno, Satoshi Inoue, Shigeki Sekine, Keisuke Matsusaki, Hiromichi Matsushita, et al. Discovery of actionable vulnerabilities in scirrhous-type gastric cancer. CANCER SCIENCE. 2022. 113
  • 中村 育子, 高阪 真路, 宿谷 威仁, 光石 陽一郎, 高橋 史行, 高橋 和久, 間野 博行. 胸水腫瘍細胞のシングルセル解析手法の開発. 肺癌. 2021. 61. 6. 764-764
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Professional career (2)：
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Awards (11)：
  • 2020 - The Japan Academy Japan Academy Prize
  • 2012/11 - Medal with Purple Ribbon from The Emperor of Japan
  • 2012/11 - The Keio University Medical Science Fund The Keio Medical Science Prize
  • 2011 - 第一三共生命科学研究振興財団 高峰記念第一三共賞
  • 2011 - 文部科学省 文部科学大臣表彰科学技術賞
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Association Membership(s) (2)：
日本内科学会 ,  日本癌学会
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