Rchr
J-GLOBAL ID：200901029942045456   Update date: Oct. 09, 2024

Mano Hiroyuki

マノ ヒロユキ | Mano Hiroyuki
Affiliation and department：
The University of Tokyo Division of Functional Genomics

About The University of Tokyo Division of Functional Genomics


Job title： Professor
Research field  (1)： Molecular biochemistry
Research keywords  (4)： carcinogenesis ,  genomics ,  Oncogene ,  Genomics
Research theme for competitive and other funds  (43)：
  • 2010 - 2016 Integrative Research on Cancer Microenvironment Network
  • 2010 - 2012 Basic study of immunotherapy with peptide vaccine in PNH
  • 2005 - 2009 Molecular targeted therapy of hematological malignancies based on the genomic information
  • 2003 - 2005 Development of a new classification for AML based on the gene expression profile in leukemia stem cells.
  • 2001 - 2004 本態性高血圧症および心不全発症機構に関する包括的ゲノム解析
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Papers (205)：
  • Takeshi Hirose, Masachika Ikegami, Kumiko Kida, Toshihide Ueno, Rina Kitada, Lei Wang, Shinya Tanaka, Makoto Endo, Yasuharu Nakashima, Naoki Kanomata, et al. Cancer risk assessment of premalignant breast tissues from patients with BRCA mutations by genome profiling. NPJ breast cancer. 2024. 10. 1. 87-87
  • Hidenori Kage, Shinji Kohsaka, Kenji Tatsuno, Kousuke Watanabe, Aya Shinozaki-Ushiku, Hideaki Isago, Tetsuo Ushiku, Hiroyuki Aburatani, Hiroyuki Mano, Katsutoshi Oda. Molecular analysis of non-small cell lung cancer using a dual-targeted DNA and RNA comprehensive genomic profiling panel. Respiratory investigation. 2024. 62. 5. 910-913
  • Fumiaki Mukohara, Kazuma Iwata, Takamasa Ishino, Takashi Inozume, Joji Nagasaki, Youki Ueda, Ken Suzawa, Toshihide Ueno, Hideki Ikeda, Katsushige Kawase, et al. Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 35. e2320189121
  • Hiroshi Ikeuchi, Yusuke Matsuno, Rika Kusumoto-Matsuo, Shinya Kojima, Toshihide Ueno, Masachika Ikegami, Rina Kitada, Hitomi Sumiyoshi-Okuma, Yuki Kojima, Kan Yonemori, et al. GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway. Oncogene. 2024
  • Shinji Kohsaka, Shigehiro Yagishita, Yukina Shirai, Yusuke Matsuno, Toshihide Ueno, Shinya Kojima, Hiroshi Ikeuchi, Masachika Ikegami, Rina Kitada, Ken-ichi Yoshioka, et al. A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency. npj Precision Oncology. 2024. 8. 1
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MISC (81)：
  • 熊谷 尚悟, 小山 正平, 板橋 耕太, 冨樫 庸介, 吉田 達哉, 石井 源一郎, 河津 正人, 山崎 直也, 坪井 正博, 谷田部 恭, et al. 腫瘍微小環境における制御性T細胞に特徴的な代謝学的チェックポイントの同定(Identification of a distinctive metabolic checkpoint of regulatory T cells in the tumor microenvironment). 日本癌学会総会記事. 2022. 81回. CES1-3
  • 石野 貴雅, 上野 敏秀, 上田 優輝, 間野 博行, 石原 聡一郎, 加藤 直也, 河津 正人, 冨樫 庸介. その機能がnon-inflamedな腫瘍微小環境を誘導し得る逆説的なネオ抗原の存在(Paradoxical neoantigens; neoantigens can paradoxically induce a non-inflamed tumor microenvironment via gene functions.). 日本癌学会総会記事. 2022. 81回. P-2171
  • Shinobu Tsuzuki, Takahiko Yasuda, Masahito Kawazu, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Masashi Sanada, Hirokazu Nagai, Akihiro Tomita, Yoshiyuki Takahashi, et al. Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. CANCER SCIENCE. 2022. 113. 1236-1236
  • Yosuke Tanaka, Fumiko Chiwaki, Shinya Kojima, Masahito Kawazu, Masayuki Komatsu, Toshihide Ueno, Satoshi Inoue, Shigeki Sekine, Keisuke Matsusaki, Hiromichi Matsushita, et al. Discovery of actionable vulnerabilities in scirrhous-type gastric cancer. CANCER SCIENCE. 2022. 113
  • 中村 育子, 高阪 真路, 宿谷 威仁, 光石 陽一郎, 高橋 史行, 高橋 和久, 間野 博行. 胸水腫瘍細胞のシングルセル解析手法の開発. 肺癌. 2021. 61. 6. 764-764
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Professional career (2)：
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Awards (11)：
  • 2020 - The Japan Academy Japan Academy Prize
  • 2012/11 - Medal with Purple Ribbon from The Emperor of Japan
  • 2012/11 - The Keio University Medical Science Fund The Keio Medical Science Prize
  • 2011 - 第一三共生命科学研究振興財団 高峰記念第一三共賞
  • 2011 - 文部科学省 文部科学大臣表彰科学技術賞
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Association Membership(s) (2)：
日本内科学会 ,  日本癌学会
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