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J-GLOBAL ID：200901029964825412   Update date: Nov. 18, 2024

Tsuchiya Yuuichi

ツチヤ ユウイチ | Tsuchiya Yuuichi
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Affiliation and department：
Toho University Faculty of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences

About Toho University Faculty of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences


Job title： Associate Professor
Research field  (2)： Developmental biology ,  Cell biology
Research keywords  (7)： Interorgan network ,  Senescence ,  Liver fibrosis ,  non-alcoholic fatty liver disease ,  Oocyte ,  Egg ,  Apoptosis
Research theme for competitive and other funds  (8)：
  • 2023 - 肝障害における増殖因子を介した修復と線維化のバランス制御および治療への応用
  • 2020 - 2023 非アルコール性脂肪性肝炎に対する増殖因子を介した肝臓修復機構の解明と治療への応用
  • 2017 - 2020 Development of serum biomarkers and therapeutic strategy for non-alcoholic steatohepatitis using liver-specific apoptosis-prone mice
  • 2017 - 2019 肝細胞死亢進マウスを用いた非アルコール性脂肪性肝炎のバイオマーカーと治療法の開発
  • 2005 - 2008 卵の生と死を制御する蛋白質分解機構間のクロストーク
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Papers (31)：
  • Tsuchiya Y*†, Nishina T†, Komazawa-Sakon S†, Seki T†, Mikami T†, Nakano H†. Interleukin-11 signaling plays limited roles for liver fibrosis in a mouse model of metabolic dysfunction-associated steatohepatitis. Biochemical and biophysical research communications. 2024. 739. 150938
  • Induction of hepatic stellate cell proliferation and liver fibrosis by FGF18. Cliical Immunology & Allergology. 2024. 81. 5. 425-431
  • Tsuchiya Y*†, Seki T†, Nakano H†, Tanaka M, Takahashi R†. Aging-associated Cyst Formation and Fibrosis. Yakugaku Zasshi. 2024. 144. 4. 397-402
  • Tsuchiya Y†, Seki T†, Kobayashi K, Komazawa-Sakon S†, Shichino S, Nishina T†, Fukuhara K, Ikejima K, Nagai H†, Igarashi Y†, et al. Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis. Nature Communications. 2023. 14. 1
  • Tsuchiya Y†, Komazawa-Sakon S†, Tanaka M, Kanokogi T†, Moriwaki K†, Akiba H, Yagita H, Okumura K, Entzminger KC, Okumura CJ, et al. A high-sensitivity ELISA for detection of human FGF18 in culture supernatants from tumor cell lines. Biochemical and biophysical research communications. 2023. 675. 71-77
ｍore...
MISC (12)：
ｍore...
Patents (1)：
  • 非アルコール性脂肪性肝炎(NASH)の検出方法
Lectures and oral presentations  (64)：
  • FGF18は星細胞の増殖を誘導し肝線維化を引き起こす
    (第31回肝細胞研究会 2024)
  • 肝線維化モデルマウスを用いた抗線維化薬のスクリーニング
    (JST新技術説明会 2024)
  • 健康に生きるためのタンパク質の生体内における役割
    (令和5年 薬学部鶴風会千葉支部総会・研修会 2023)
  • Aging-related cyst formation and fibrosis
    (2023)
  • Fibroblast growth factor 18 activates hepatic stellate cells that lead to liver fibrosis
    (The Japanese Biochemical Society 2022)
ｍore...
Education (2)：
  • 1991 - 1996 The University of Tokyo Graduate School, Division of Science Department of Biochemistry and Biophysics
  • 1987 - 1991 The University of Tokyo Faculty of Science Department of Biochemistry and Biophysics
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (7)：
  • 2022/09 - 現在 Toho University Faculty of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences Associate Professor
  • 2012/12 - 2022/08 Toho University Faculty of Medicine
  • 2012/02 - 2022/08 Toho University Faculty of Medicine School of Medicine Lecturer
  • 2007/04 - 2012/01 Toho University Faculty of Medicine School of Medicine Assistant Professor
  • 2007/04 - 2012/01 Toho University Faculty of Medicine
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Awards (1)：
  • 2011/11 - Medical Society of Toho University Medical Society of Toho University Award Anti-apoptotic activity and proteasome-mediated degradation of Xenopus Mcl-1 protein in egg extracts.
Association Membership(s) (7)：
Japanese Society for the Research of Hepatic Cells ,  Society for Senescence- Accelerated Mouse (SAM) Research ,  Japan Society for Biomedical Gerontology ,  The Pharmaceutical Society of Japan ,  Japanese Society for Cell Death ,  The Molecular Biology Society of Japan ,  The Japanese Biochemical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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