Rchr
J-GLOBAL ID：200901030070743706
Update date: Jul. 05, 2024
Imanishi Miki
イマニシ ミキ | Imanishi Miki
Affiliation and department：
Homepage URL (1)：
http://www.scl.kyoto-u.ac.jp/~bfdc/index.html
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (2)：
生体機能化学
, biofunctional chemistry
Research theme for competitive and other funds (19)：
- 2022 - 2025 Site-specific and high efficient epitranscriptomic manipulation based on the enzymatic activity
- 2021 - 2024 Elucidation of the mechanism for dimensional response genome
- 2021 - 2024 Biological function of non-canonical nucleic acids
- 2021 - 2023 配列・環境依存的エピトランスクリプトーム制御法の開発と体内時計制御への展開
- 2019 - 2022 Control of RNA modification aimed at antivirus activities
- 2016 - 2019 Sequence specific detection and manipulation of epigenetic status
- 2016 - 2018 Exploration of synthetic molecules that control intrinsically disordered proteins
- 2014 - 2016 細胞時計同調の包括的理解と人為的制御のための人工入力系の構築
- 2012 - 2015 Elucidation of DNA binding modes of TALEs and creation of artificial DNA binding proteins
- 2012 - 2014 細胞時計を模倣した周期的遺伝子発現システムの構築
- 2010 - 2012 Creation of artificial clock proteins to induce rhythmic gene expression
- 2009 - 2011 DNA結合タンパク質の揺らぎによる配列特異的DNA結合への影響
- 2009 - 2011 Effects of fluctuations of DNA binding proteins on their sequence-specificities
- 2008 - 2010 亜鉛フィンガーを利用した人工転写因子の創製と人工遺伝子回路形成への展開
- 2008 - 2010 Design of artificial zinc finger-type transcription factors toward creation of artificial gene circuits
- 2006 - 2007 亜鉛フィンガータンパク質間相互作用に基づく新規転写促進分子の創製
- 2005 - 2007 Creation of New Functional Artificial Metallofingers : Construction of Library and Development to Gene Regulation
- 2005 - 2006 Development of intracellular targeting peptide vectors and the real-time observation in cells.
- 2004 - 2005 世界最長のマルチ亜鉛フィンガーの創製と新機能
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Papers (78)：
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Kazuya Yamanaka, Yoshihisa Inoue, Miki Imanishi, Junko Ohkanda. Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors. Bioorganic & medicinal chemistry letters. 2024. 98. 129588-129588
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Kamui Tanaka, Akiyo Suda, Motonari Uesugi, Shiroh Futaki, Miki Imanishi. Xanthine derivatives inhibit FTO in an L-ascorbic acid-dependent manner. Chemical communications (Cambridge, England). 2023. 59. 72. 10809-10812
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Shigeru Negi, Miki Imanishi, Mami Hamori, Yuka Kawahara-Nakagawa, Wataru Nomura, Kanae Kishi, Nobuhito Shibata, Yukio Sugiura. The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2023. 28. 3. 249-261
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Motoki Nishimura, Yoshimasa Kawaguchi, Kakeru Kuroki, Yuna Nakagawa, Toshihiro Masuda, Takayuki Sakai, Kenichi Kawano, Hisaaki Hirose, Miki Imanishi, Tomoka Takatani-Nakase, et al. Structural Dissection of Epsin-1 N-Terminal Helical Peptide: The Role of Hydrophobic Residues in Modulating Membrane Curvature. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. 29. 29. e202300129
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Shigeru Negi, Mami Hamori, Yuka Kawahara-Nakagawa, Masato Mashimo, Miki Imanishi, Nozomi Kuki, Yuri Kawahito, Takayuki Manabe, Nobuyuki Kawamura, Jyunichiro Yasukawa, et al. Effect of charged-cluster distribution of the ZIF268 zinc finger surface on cell membrane permeability. Chemistry Letters. 2022
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MISC (51)：
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細谷侑佑, 能條航, 喜井勲, 鈴木孝紀, 今西未来, 大神田淳子. Exploration of synthetic agents that inhibit intrinsically disordered circadian clock transcription factors. 日本化学会春季年会講演予稿集(Web). 2021. 101st
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NOSHIRO Daisuke, SONOMURA Kazuhiro, YU Hao-Hsin, IMANISHI Miki, ASAMI Koji, FUTAKI Shiroh. Construction of a Calcium-gated Artificial Channel by Fusing Alamethicin with a Calcium Sensor Protein. 2013. 2012. 183-184
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今西未来, 中村篤史, 山本和俊, 土居雅夫, 岡村均, 二木史朗. 人工DNA結合蛋白質による細胞分子時計の操作. 「細胞を創る」研究会5.0 ,横浜(東京工業大学). 2012
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Imanishi, M, Nakamura, A, Doi, M, Okamura, H, Futaki, S. Control of Cellular Circadian Phase by an Artificial Zinc-Finger Transcription Factor. 第39回国際核酸化学シンポジウム ,名古屋. 2012
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TSUJI, S, Imanishi, M, Futaki, S. 5'-Tthymine recognition by TAL effectors. The 39th Inernational Symposium on Nucleic Acids Chemistry ,Toyoda Auditorium, Nagoya University. 2012
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Lectures and oral presentations (87)：
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Development of a simple detection method of RNA modification and its application
(2024)
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配列・タイミング依存的なRNA修飾操作法の開発
(日本薬学会第144年会 2024)
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RNA脱メチル化酵素FTOの阻害剤探索及びFTOの補酵素としてのL-アスコルビン酸の役割
(日本薬学会第144年会 2024)
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RNAメチル化の人為的制御
(第40回メディシナルケミストリーシンポジウム 2023)
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核酸構造の多元機能とエピトランスクリプトームとの 接点を知る
(第13回CSJ化学フェスタ2023 2023)
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Education (5)：
- - 2002 Kyoto University
- - 1999 Kyoto University
- - 1999 Kyoto University Graduate School, Division of Pharmaceutical Sciences
- - 1997 Kyoto University Faculty of Pharmaceutical Sciences
- - 1997 Kyoto University Faculty of Pharmaceutical Science
Professional career (1)：
- Doctor of Pharmaceutical Science (Kyoto University)
Awards (4)：
- 2023/05 - 日本女性科学者の会 第28回日本女性科学者の会奨励賞 RNAメチル化の酵素化学的検出法の開発と選択的制御への展開
- 2013/04 - 平成25年度文部科学大臣表彰若手科学者賞 細胞機能を制御する人工DNA結合タンパク質デザインの研究
- 2012/03 - 日本薬学会 平成24年度日本薬学会奨励賞 人工DNA結合タンパク質のデザインと細胞機能制御への展開
- 2011/12 - 京都大学化学研究所 第16回京大化研奨励賞 細胞時計のリセットを誘起する人工転写因子の創製
Association Membership(s) (4)：
日本薬学会
, RNA Society
, 日本時間生物学会
, 日本生化学会
