Rchr

J-GLOBAL ID：200901031121179416 Update date: Feb. 01, 2024

Takano Mikihisa

タカノミキヒサ | Takano Mikihisa

Affiliation and department：

Research field (1)： Environmental and pharmaceutical development resources

Research keywords (5)： organ/cell toxicity of drugs , endocytosis , transporter , pharmacokinetics , biopharmaceutics

Research theme for competitive and other funds (31)：

2022 - 2025 Analysis of innate immune response of alveolar macrophages and epithelial-mesenchymal transition of alveolar epithelial cells
2022 - 2025 Mechanistic study on cancer progression based on the comparison between antitumor effects and epithelial-mesenchymal transition by anticancer drugs
2021 - 2024 肺胞上皮細胞におけるPEPT2介在性輸送および自然免疫応答に及ぼす薬物の影響
2018 - 2021 薬剤性肺線維症の原因、バイオマーカーおよび治療標的としてのマイクロRNA
2015 - 2018 Study on the mechanism of epithelial-mesenchymal transition as a cause of drug-induced lung injury, and development of the strategy for preventing the injury

2014 - 2017 Analysis of molecular mechanism of drug-induced lung fibrosis and development of strategy to predict and prevent the fibrosis

2014 - 2016 Development of a novel model of alveolar type I cells for the study on drug transport and toxicity in the lung

2012 - 2015 Analysis of the drug-induced lung toxicity in relation to transdifferentiation of type II cells into type I cells and epithelial-mesenchymal transition

2011 - 2014 Research on the anticancer effects and multidrug-resistance modulating effects of Thai plants

2011 - 2013 Analysis of low temperature tolerance of membrane transporters and development of pan-transporter inhibitors

2010 - 2013 Establishment of a new alveolar epithelial cell model by gene transfection and its application to the study on drug transport and toxicity in the lungs

2009 - 2011 Study on the transportsome for ribavirin uptake in human erythrocyte membrane

2007 - 2009 Search for traditional medicines in Thailand and scientific evaluation of their pharmacological effects

2007 - 2009 Study on the transport of proteins in alveolar type I/II epithelial cells for the development of new pulmonary DDS systems

2007 - 2008 Drug Transport in human erythrocyte membrane and drug interaction/adverse reaction in erythrocyte

2007 - 2008 Pharmacokinetic properties of vitamin-binding proteins and these application to vector for drug delivery

2005 - 2006 Development of protein drug delivery system from the lung based on ligand recognition mechanisms of the receptors

2001 - 2002 Studies on the mechanisms underlying renal tubular deficiency due to the lack of the expression and function of CLCN5, a gene responsible for Dent's disease

2001 - 2001 植物エストロゲンの体内動態と生体防御・解毒機構に及ぼす影響解析

1999 - 2001 Effect of endocrine disrupting chemicals on host defense mechanism (transpoter, enzymes)

1999 - 2000 Search for the new, endogenous compound with multidrug resistance modulating activity and its application to cancer chemotherapy

1997 - 1998 メガリン(gp330)の分子・細胞生物学的解析と新規薬物送達システム開発への応用

1996 - 1996 発育に伴う薬物腎排泄能変化の分子機構に関する研究

1994 - 1995 Molecular and Cell Biological Analyzes of Structure and Function of Drug Transporters in the Intestine and Kidney Proximal Tubule

1994 - 1994 小腸上皮細胞におけるプロトン勾配駆動型薬物能動輸送活性の発現とその制御

1994 - 1994 腎尿細管薬物輸送担体のストレス応答

1993 - 1993 分子生物学的手法を用いたアミノグリコシド系抗生物質の腎毒性発現機構の解折

1993 - 1993 腎尿細管上皮細胞膜における有機カチオン輸送の分子機構

1992 - 1992 腎尿細管上皮細胞膜における有機カチオン輸送の分子機構

1991 - 1992 Scientific Basis of Drug Disposition in the Kidney and its Application to Clinical Dosage Regimens.

1989 - 1990 In Vitro New Evaluation Method for the Drug Absorption and Secretion Using Membrane Vesicles

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Papers (315)：

Ogiso, Hideo, Suno, Ryoji, Kobayashi, Takuya, Kawami, Masashi, Takano, Mikihisa, Ogasawara, Masaru. A Liquid Chromatography-Mass Spectrometry Method to Study the Interaction between Membrane Proteins and Low-Molecular-Weight Compound Mixtures. MOLECULES. 2022. 27. 15
Katagiri, Yuki, Kawaguchi, Hiroko, Umemura, Koji, Tadano, Jun, Miyawaki, Izuru, Takano, Mikihisa. Investigation of the role and quantitative impact of breast cancer resistance protein on drug distribution into brain and CSF in rats. DRUG METABOLISM AND PHARMACOKINETICS. 2022. 42
Takano, Mikihisa, Kuriyama, Shiori, Kameda, Nanako, Kawami, Masashi, Yumoto, Ryoko. Effect of Corticosteroids on Peptide Transporter 2 Function and Induction of Innate Immune Response by Bacterial Peptides in Alveolar Epithelial Cells. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2022. 45. 2. 213-219
Kawami, Masashi, Yumoto, Ryoko, Takano, Mikihisa. Preventive approach against drug-induced pulmonary fibrosis through the suppression of epithelial-mesenchymal transition. BIOCELL. 2022. 46. 8. 1861-1865
Kawami, Masashi, Takenaka, Shinnosuke, Akai, Mizuki, Yumoto, Ryoko, Takano, Mikihisa. Characterization of miR-34a-Induced Epithelial-Mesenchymal Transition in Non-Small Lung Cancer Cells Focusing on p53. BIOMOLECULES. 2021. 11. 12

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MISC (2)：

原林六華, 宮本未緒花, 川見昌史, 湯元良子, 高野幹久. P0296-22-AM メトトレキサートによる上皮間葉転換誘発機構の解析とそれに基づく薬剤性肺障害の防御標的の探索(有害事象・副作用1,ポスター発表,一般演題,医療薬学の進歩と未来-次の四半世紀に向けて-). 日本医療薬学会年会講演要旨集. 2015. 25. 315-315
MURAKAMI Teruo, FUKUDA Takeshi, YUMOTO Ryoko, NAGAI Junya, KURAMOTO Taiju, TAKANO Mikihisa. Interaction of Endogenous Compounds in Human and Rat Urine with P-glycoprotein. 2002. 17. 3. 245-252

Books (31)：

「スタンダード薬学シリーズII 6 医療薬学 V. 薬物治療に役立つ情報」補訂版
東京化学同人 2021
次世代吸入製剤とデバイスの開発
シーエムシー出版 2018
スタンダード薬学シリーズII 6 医療薬学 V. 薬物治療に役立つ情報 SBO51 腎疾患・腎機能低下時における薬物動態と、薬物治療・投与設計において注意すべき点を説明できる
東京化学同人 2017
「製剤学改訂第7版」
南江堂 2017
スタンダード薬学シリーズII6
東京化学同人 2016

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Lectures and oral presentations (279)：

In vitro and in vivo studies on involvement of miR-222 in epithelial-mesenchymal transition in alveolar epithelial cells
(日本薬物動態学会第36年会 2022)
Effect of 2-deoxy-D-glucose on transforming growth factor-β1-induced epithelialmesenchymal transition in alveolar epithelium
(日本薬物動態学会第36年会 2022)
肺胞上皮細胞における高分子および低分子物質の輸送とその制御
(第12回粉末吸入剤研究会シンポジウム 2022)
ヒト肺胞上皮A549/ABCA3細胞におけるmiR-34aによる上皮間葉転換機構の解明
(第60回日本薬学会・日本薬剤師学会・日本病院薬剤師学会中国四国学術大会 2022)
ヒト肺胞上皮細胞の上皮間葉転換に対する終末糖化産物および高濃度グルコースの影響
(第60回日本薬学会・日本薬剤師学会・日本病院薬剤師学会中国四国学術大会 2022)

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Education (3)：

1982 - 1985 Kyoto University Graduate School, Division of Pharmaceutical Sciences
1982 - 1985 Kyoto University Graduate School, Division of Pharmaceutical Sciences
1976 - 1980 Kyoto University Faculty of Pharmaceutical Science

Professional career (2)：

Doctor of Pharmaceutical Sciences (Kyoto University)
Master of Pharmaceutical Science (Kyoto University)

Work history (7)：

2019/04/01 - Hiroshima University Graduate School of Biomedical & Health Sciences Professor
2002/04/01 - 2019/03/31 Hiroshima University Graduate School of Biomedical Sciences Professor
2002/04/01 - 2019/03/31 Hiroshima University Graduate School of Biomedical Sciences Professor
1996/06/01 - 2002/03/31 Hiroshima University Faculty of medicine Professor
1995/02/16 - 1996/05/31 Kyoto University Hospital Associate Professor

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Awards (11)：

2021/01/23 - 公益社団法人日本薬学会中国四国支部支部長第59回日本薬学会中国四国支部学生発表奨励賞乳腺上皮細胞におけるニコチン輸送機構の解明
2021/01/23 - 公益社団法人日本薬学会中国四国支部支部長第59回日本薬学会中国四国支部学生発表奨励賞メトトレキサート誘発性上皮間葉転換における ITGA2 の関与
2019/05/10 - 日本膜学会会長日本膜学会第41年会学生賞ニコチンの生体膜輸送におけるアンモニアトランスポーターの関与
2015/11/13 - The Japanese Society for the Study of Xenobiotics JSSX Award 2015
2011/05/21 - 広島県薬剤師会会長広島県薬剤師会賞広島県薬剤師会の活動への多年にわたる貢献が認定

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Association Membership(s) (6)：

The Academy of Pharmaceutical Science and Technology, Japan , Japanese Society of Pharmaceutical Health Care and Sciences , The Japanese Society for the Study of Xenobiotics , International Society for the Study of Xenobiotics , The Membrane Society of Japan , The Pharmaceutical Society of Japan

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